Antineoplastic Agents

List of Contributors

General Preface

Preface to Volume III

Part I General Reviews

1 Nucleoside Analogues

I. Introduction

II. Cytosine Arabinoside

III. 5-Azacytidin

IV. 5-Fluorouracil

V. Other 5-Fluoro Pyrimidines

VI. 3-Deazauridine

VII. Purine Analogs

VIII. Arabinosyl Adenine

IX. Conclusions

References

2 Cyclophosphamide and Analogues

I. Introduction

II. Structure and Metabolism

III. Clinical Pharmacology

IV. Toxicities

V. Clinical Activity and Dose Schedules

VI. Analogues

References

3 Nitrosoureas

I. Introduction

II. Decomposition and Metabolism

III. Mechanism of Action

IV. Clinical Use

V. Clinical Toxicities

VI. Discussion

References

4 Mitomycin C - An Overview

I. Introduction

II. Chemistry

III. Structure-Activity Relationships

IV. Molecular Pharmacology

V. Pharmacology

VI. Clinical Effects

VII. Conclusions

References

5 Other Alkylating Agents

I. Introduction

II. Mechanism of Action

III. Other Alkylating Agents

IV. Conclusions

References

6 The Vinca Alkaloids and Similar Compounds

I. The Vinca Alkaloids

II. The Podophyllotoxin Derivatives

III. Maytansine

References

7 Bleomycin - An Overview

I. Introduction

II. Chemistry

III. Molecular Pharmacology

IV. Clinical Pharmacology

V. Clinical Activities

VI. Clinical Toxicities

VII. Conclusions

References

8 The Anthracyclines

I. Introduction

II. Chemistry

III. Molecular Pharmacology

IV. Clinical Pharmacology

V. Clinical Activities of Adriamycin and Daunorubicin

VI. Toxicities of Adriamycin

VII. Anthracyclines in Development

References

9 Cisplatin and Analogues: A New Class of Anticancer Drugs

I. Introduction

II. Antitumor Activity in Animal Tumors

III. Animal Toxicology

IV. Efficacy

V. Toxicity

VI. Cisplatin Analogues

VII. Conclusion

References

10 Investigational Cancer Drugs

I. Introduction

II. Alkylating Agents

III. Anthracycline Analogues

IV. Tubulin Binding Agents

V. Antitumor Antibiotics

VI. Nitrosoureas

VII. Antimetabolites

VIII. Miscellaneous

IX. Summary

References

11 Hormone Therapy

I. Basis of Endocrine Therapy

II. Prostatic Cancer

III. Breast Cancer

IV. Cancer of the Uterine Endometrium

V. Lymphomas

VI. Summary

References

12 A Human Tumor Stem Cell System: Concepts, Methodology, and Application

I. Introduction

II. Methodology

III. Applications

IV. Conclusions

References

Part II Molecular Pharmacology of Selected Antineoplastic Agents

13 The Molecular Pharmacology of Bleomycin

I. Introduction

II. Chemistry

III. The Interactions of Metals with Bleomycin and Analogues

IV. Effects of Bleomycin on Isolated DNA

V. Cellular Effects

VI. Effects on the Cell Cycle

VII. Morphological Effects

VIII. Intracellular Fate and Metabolism

IX. Conclusions

References

14 Molecular Pharmacology of Anthracycline Antitumor Antibiotics

I. Introduction

II. Chemistry

III. Studies on the Mechanism of Action of Anthracyclines

IV. Anthracycline Structure-Activity Relationships

V. Conclusions

References

15 Vinca Alkaloids: Molecular and Clinical Pharmacology

I. Introduction

II. Molecular Structure

III. Molecular Pharmacology

IV. Clinical Pharmacology

V. Conclusion

References

16 Molecular Pharmacology of Alkylating Agents

I. Introduction

II. Chemistry of the Alkylating Reactions

III. Clinically Effective Alkylating Agents

IV. Reactions with Biological Molecules

V. Discussion

References

17 Molecular Pharmacology of Cisplatin

I. Introduction

II. Chemistry

III. Biochemistry and Mechanism of Action

IV. Conclusion

References

18 Methotrexate: Molecular Pharmacology

I. Introduction

II. Chemistry

III. Mechanism of Action and Structure-Activity Relationships

IV. Transport of Methotrexate and Related Compounds

V. Mechanisms of Resistance to Folate Antagonists

VI. The Future for Folate Antagonists

References

Part III Clinical Pharmacology of Selected Neoplastic Agents

19 Introduction to Clinical Pharmacology

I. Introduction

II. Pharmacokinetics

III. Mathematical Modeling

IV. Clinical Correlations of Pharmacokinetics

V. Discussion

References

20 Clinical Pharmacology of Bleomycin

I. Introduction

II. Newer Clinical Pharmacological Assays for Bleomycin

III. Absorption

IV. Distribution

V. Elimination

VI. Conclusions

References

21 Clinical Pharmacology of Cisplatin

I. Introduction

II. Cisplatin Pharmacokinetics

III. Cisplatin Stability

IV. Conclusion

References

22 Methotrexate: Clinical Pharmacology and Therapeutic Application

I. Introduction

II. Pharmacology

III. Clinical Applications

IV. Discussion

References

23 Clinical Pharmacology of Nitrosoureas

I. Introduction

II. Molecular Structure

III. Biochemistry and Metabolism

IV. Clinical Pharmacology

V. Discussion

References

Index