Antibody Production in Man

Contributors Preface1 Consideration of Antibody Deficiency Diseases in Relation to Normal B-Cell Development 2 Pokeweed Mitogen-Induced Responses of Human Peripheral Blood Lymphocytes: Regulation of B-Cell Triggering 3 Induction of Antibody Synthesis in Human Lymphocytes from Different Organs by Different PBA Substances 4 The Plaque-Forming Cell Response of Human Blood Lymphocytes. Cocultivation of Lymphocytes from Different IndividualsGeneral Discussion Mitogen-Induced B-Cell Activation. I. 5 T—T Interactions in the Generation of Human Suppressor Effector Cells in Vitro 6 Biosynthesis and Secretion of Immunoglobuhns by Human Peripheral Blood Lymphocytes 7 Antigen-Specific and Antigen-Nonspecific Triggering of Human B LymphocytesGeneral Discussion Mitogen-Induced B-Cell Activation. II. 8 Antigen-Induced Regulation of the PFC Response in Man 9 Human B-Cell Activation in Vitro: Regulation by Antigen- Specific Human Suppressor T Cells 10 Primary in Vitro Antibody Response to TNP-PAA: Cellular BasisGeneral Discussion Antigen-Induced B-Cell Activation. I. 11 T-B Collaboration in the in Vitro Ab Response to Diphtheria Toxoid: Evidence Favoring a Role for B Cells in the Generation of T-Cell Help 12 Antigen-Dependent PFC Induction in Cultures of Human Peripheral Blood Lymphocytes 13 Human Antigen-Specific Helper T-Cell Factors in B-Cell Responses General Discussion Antigen-Induced B-Cell Activation. II. 14 Clinical Relevance of Subpopulation of Human T Lymphocytes 15 Further Studies on the IgM Receptors Located on the Surface of B Cells 16 Distinct Human T-Cell Subpopulations Regulating the Antigen-Induced Antibody Response General Discussion Subpopulations of Lumphocytes Involved in the in Vitro Regulation of B-Cell Function. I. 17 Generation of Plaque-Forming Cells: Allogenic Effect and Significance of Monocyte Removal 18 Regulation of Human B-Cell Differentiation by T-Cell Subclasses 19 Effect of Hydrocortisone on the Kinetics and Function of Peripheral Blood Immunoregulatory Cells in Man General Discussion Subpopulations of Lymphocytes Involved in the in Vitro Regulation of B-Cell Function. II. 20 In Vitro Functional Heterogeneity of Humoral and Cellular Immune Deficiency States 21 Immoglobulin Secreting Cells in the Circulating Bloodand Mitogen-Stimulated Cultures from Patients with Immunodeficiency Diseases 22 Polyclonal B-Cell Activation in the Analysis of Immunodeficiency States General Discussion Clinical Implications in the Study of in Vitro B-Cell Function. I. 23 Aberrant Regulation of B-Cell Function in Immunologically Mediated Diseases: Systemic Lupus Erythematosus and Sarcoidosis 24 The Cellular Defeat in IgA Deficiency: Possible Links to Hypogammaglobulinemia 25 Subpopulation of Human T Lymphocytes: Functional Characteristics General Discussion Clinical Implications in the Study of in VitroB-Cell Function. IISummary of Workshop Human B-Cell Function: Recent Advances, Unanswered Questions,and Future DirectionsIndex