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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biolog… Read more
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II. CARDIOVASCULAR AND METABOLIC DISEASES
5. Emerging Topics in Atherosclerosis HDL Raising Therapies (P.J. Sinclair).
6. Small Molecule Anticoagulant/Antithrombotic Agents (R.M. Scarborough et al.).
7. CB1 Cannabinoid Receptor Antagonists (F. Barth).
8. Melanin-Concentrating Hormone as a Therapeutic Target (M.D. McBriar, T.J. Kowalski).
9. Glycogen Synthase Kinase-3 (GSK-3): A Kinase with Exceptional Therapeutic Potential (J.W. Benbow et al.).
10. Inhibitors of Dipeptidyl Peptidase 4 as Therapeutic Agents (S.L. Gwaltney II, J.A. Stafford).
11. Recent Advances in Therapeutic Approaches to Type 2 Diabetes (R. Sarabu, J. Tilley).
III. INFLAMMATORY, PULMONARY, AND GASTROINTESTINAL DISEASES
12. The TRPV1 Vanilloid Receptor: A Target for Therapeutic Intervention (J. Guy Breitenbucher et al.).
13. Leukotriene Biosynthesis Inhibitors (R.W. Friesena, D. Riendeaub).
14. CXCR3 Antagonists (J.C. Medina et al.).
15. PDE7 inhibitors: chemistry and potential therapeutic utilities (F. Vergne et al.).
IV. CANCER AND INFECTIOUS DISEASES
16. Inhibitors of Anti-apoptotic Proteins for Cancer Therapy (S.W. Elmore et al.).
17. AKT Kinase and Hsp90 Inhibitors As Novel Anti-cancer Therapeutics (T. Machajewski et al.).
18. Novel Strategies in HIV Prevention – Development of Topical Microbicides (B.E. Beer, J.E. Cummins, Jr.).
19. New Developments in HIV Therapeutics (T.A. Lylea, M.D. Millerb).
20. Antibacterials for the Treatment of Gram Positive Infections (J.B. McAlpinea, Morimasa Yagisawab).
21. Progress on New Therapeutics for Fungal Nail Infections (S.J. Baker et al.).
V. TOPICS IN BIOLOGY
22. Chemical Tools for Indications Discovery (A. Hopkins).
23. Structural Genomics and Drug Discovery (A. Edwards et al.).
VI. TOPICS IN DRUG DESIGN AND DISCOVERY
24. Structural Genomics and Drug Discovery (A. Edwards et al.).
25. G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological Relevance and Functional Assays (B.L. Chenard et al.).
26. The Utility of Metabonomics for Drug Safety Assessment (M. Delnomdedieu, R.P. Schneider).
27. Computational Prediction of Blood-brain Barrier Permeation (D.E. Clark).
28. Pharmacogenetics and Drug Development (H. Reiser).
VII. TRENDS AND PERSPECTIVES
29. Trends in Pharmaceutical Innovation (E.F. Schmid, D.A. Smith).
30. To Market, To Market – 2004 (S. Hegde, M. Schmidt).
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