Animal Models of Molecular Pathology

Contributors

Preface

Animal Models of Atherosclerosis

I. Atherosclerosis Development: Basic Concepts

II. Animal Models of Atherosclerosis

III. Concluding Remarks

Acknowledgments

Genetic Animal Models of Cerebral Vasculopathies

I. Cerebral Amyloid Angiopathy

II. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)

III. Concluding Remarks

Acknowledgments

Experimental Models of Seizures and Epilepsies

I. Introduction

II. Classification of Epileptic Seizures

III. Classification of Epileptic Syndromes

IV. Models for Seizures and Epilepsies

V. Summary

Animal Models of Muscular Dystrophy

I. Dystrophin

II. The Sarcoglycans

III. Calcium and Dystrophic Pathology

IV. α-Actinin

V. Fukutin-Related Protein and Dystroglycan Processing

VI. Desmin

VII. Laminin α2

VIII. Collagen VI

IX. D4Z4 Repeats and FSHD

X. DMPK and Myotonic Dystrophy

XI. Conclusions

Acknowledgments

Acute Phase Proteins in Animals

I. The Acute Phase Response

II. Acute Phase Proteins

III. Clinical Value of APP

IV. APP in Animals

V. Concluding Remarks

Animal Models of Hemophilia

I. The Hemophilia A Mice

II. The Hemophilia B Mouse Model

III. The Hemophilia A and B Dogs

Animal Models of Lung Cancer

I. Lung Adenomas and Adenocarcinomas

II. Lung Squamous Cell Carcinoma

III. Lung Small Cell Carcinoma

IV. Chemopreventive Applications in Preclinical Lung Cancer Models

V. Conclusion

Cardiovascular Magnetic Resonance Imaging in Small Animals

I. Introduction

II. Principals of MRI

III. MRI Systems for Preclinical Imaging and Experimental Setup

IV. Cardiovascular MRI

V. Conclusion

Animal Models of Inflammatory Bowel Disease

I. Classification of Murine IBD Models

II. IL-10 KO Mice

III. IL-2 KO Mice

IV. TCRα KO Mice

V. TGFβ KO Mice

VI. TAK1 KO Mice

VII. WASP KO Mice

VIII. P110δ Mutant Mice

IX. PDK1 KO Mice

X. Cbl-b KO Mice

XI. Blimp-1 KO Mice

XII. A20 KO Mice

XIII. SHIP KO Mice

XIV. Gαi2 KO Mice

XV. TNF(ARE) Mice

XVI. LIGHT Tg Mice

XVII. TNFSF15 Tg Mice

XVIII. IL-7 Tg Mice

XIX. IL-15 Tg Mice

XX. CD40L Tg Mice

XXI. Soluble B7.2 Tg Mice

XXII. Integrin αV KO Mice

XXIII. Integrin β8 KO Mice

XXIV. STAT4 Tg Mice

XXV. STAT3 KO Mice

XXVI. SOCS1 Tg Mice

XXVII. Gp130 KI Mice

XXVIII. NFκB1 KO Mice

XXIX. Runx3 KO Mice

XXX. TLR5 KO Mice

XXXI. Enteric Glia KO

XXXII. XBP1 KO Mice

XXXIII. Atg5 KO Mice

XXXIV. mK8 KO Mice

XXXV. N-Cadherin Mutant Mice

XXXVI. Mdr1a KO Mice

XXXVII. GPX KO Mice

XXXVIII. Muc2 KO Mice

XXXIX. C1galt1 KO Mice

XL. NFATc2/RAG DKO Mice

XLI. T-bet/RAG DKO Mice

XLII. Anti-CD40mAb Model

XLIII. C3H/HeJBir Mice

XLIV. SAMP1/Yit Model

XLV. CD45RB Model

XLVI. Human CD3ε Model

XLVII. CD8-Transfer Models

XLVIII. ECOVA Model

XLIX. TNBS Model

L. Oxazolone Model

LI. DSS Model

LII. Conclusion

Acknowledgments

Animal Models of Molecular Pathology

I. Murine Models of Lupus

II. Role of the Major Histocompatibility Complex

III. Role of Cell Signaling

IV. Role of Sex Hormones

V. Role of Cytokines

VI. Tolerance Models

VII. Therapies

VIII. Conclusions

Animal Models of Cutaneous and Hepatic Fibrosis

I. Liver Fibrosis

II. Skin Fibrosis and Scleroderma

Animal Models of Schizophrenia

I. Introduction

II. The Schizophrenia Phenotype

III. Existing Animal Models for Schizophrenia

IV. An Example in Progress: A Psychosis Animal Model for Schizophrenia with High Construct Validity

V. Future Directions for Schizophrenia Models