Aliphatic and Polyhalogenated Carcinogens

General Plan

Preface

Acknowledgments

Part III (Continued) Structure-Activity Relationships of Chemical Carcinogens. Effect of Reactivity, Molecular Geometry, and Metabolism on Carcinogenic Activity

5. Structure-Activity Relationships

5.2.Nonconjugated Organic Compounds

Updating Notes

Notes Added after Completion of Section 5.2.2.1

Notes Added after Completion of Section 5.2.2.2

Notes Added after Completion of Section 5.2.2.3

Notes Added after Completion of Section 5.2.2.4

Notes Added after Completion of Section 5.2.2.5

Notes Added after Completion of Section 5.2.2.7

Notes Added after Completion of Section 5.2.2.8

Notes Added after Completion of Section 5.2.2.9

Appendix I. Novel Types of Carcinogens

Carbazole

Anthanthrene

Benzene

Furylfuramide (Furfurylamide; AF-2)

Niridazole

4-Nitropyridine N-Oxide

Quinoline and Its Derivatives

Quinoxaline 1,4-Dioxide

Benzoyl Chloride and Other Acylating Agents

Acetone Oxime (Acetoxime)

Pronamide

ZAMI 1305

Hycanthone

1,3-Butadiene

Aniline and Azobenzene

4-Aminoazobenzene

References to Appendix I

Appendix II. Update to Vol. I: New Developments in Short-Term Tests for Carcinogenicity: Genetic Toxicology Testing

Introduction

Application of Genotoxicity Data to Human Health Effects

Development of Genetic Toxicology Bioassays

Application of Short-Term Bioassays to the Assessment of Human Cancer and Mutation Risk

Concluding Remarks

References to Appendix II

Appendix III. Update to Vol. I: New Perspectives in Cancer Research Data Search: Modern Computer-Based Information Systems

Introduction

Computer Databases Useful for Cancer Research

Automatic Selective Dissemination of Information

Special Cancer Databases

Other Databases of Interest for Cancer Research

Special Publications That Provide Useful Information to Cancer Researchers

Conclusion

References to Appendix III

Appendix IV. Update to Vol. IIA: Metabolic Activation by One-Electron and Two-Electron Oxidation in Aromatic Hydrocarbon Carcinogenesis

Introduction

Enzymology of One-Electron and Two-Electron Oxidation

Two-Electron Oxidation or Monooxygenation of Aromatic Hydrocarbons

One-Electron Oxidation of Aromatic Hydrocarbons: Radical Cations

Discussion

References to Appendix IV

Index