Alginates in Drug Delivery

1st Edition - July 23, 2020
Imprint: Academic Press
Editors: Amit Kumar Nayak, Md Saquib Hasnain
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 6 4 0 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 6 4 1 - 2

Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry.… Read more

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Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field.

This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences.

Cover image
Title page
Table of Contents
Copyright
List of Contributors
Preface
Chapter 1. Alginates: sources, structure, and properties
Abstract
1.1 Introduction
1.2 Sources of alginates
1.3 Molecular structure of alginates
1.4 Properties of alginates
1.5 Conclusion
References
Chapter 2. Alginates as drug delivery excipients
Abstract
2.1 Introduction
2.2 General properties
2.3 Drug delivery applications
2.4 Conclusion
References
Chapter 3. Alginate-based hydrogels for drug delivery applications
Abstract
3.1 Introduction
3.2 Alginate: sources, chemistry, and properties
3.3 Preparations of alginate-based hydrogels
3.4 Drug delivery applications
3.5 Conclusion
References
Chapter 4. Grafted alginates in drug delivery
Abstract
4.1 Introduction
4.2 Chemical modifications and design strategies for alginate
4.3 Grafting derivatives of alginates
4.4 Uses of grafted alginates in drug delivery applications
4.5 Limitations of grafted alginate for the use in drug delivery
4.6 Conclusion
References
Chapter 5. Alginate-based interpenetrating polymer networks for sustained drug release
Abstract
5.1 Introduction
5.2 IPNs and their uses in drug delivery
5.3 Alginates
5.4 The need for modifications alginates
5.5 Insights into the use of alginate-based IPNs for sustained release drug delivery
5.6 Conclusion
References
Chapter 6. Alginate nanoparticles in drug delivery
Abstract
6.1 Introduction
6.2 Alginate
6.3 Preparations of alginate nanoparticles for drug delivery
6.4 Recent advances in using alginate nanoparticles in drug targeting
6.5 Limitations for use of alginate in pharmaceutical nanotechnology
6.6 Future perceptive in using alginate particles as nanocarriers
6.7 Conclusion
References
Chapter 7. Biocomposites of Alginates in Drug Delivery
Abstract
7.1 Introduction
7.2 Composites and biocomposites
7.3 Sources of alginates
7.4 Chemistry of alginate-structure
7.5 Properties of alginates
7.6 Various alginate-based biocomposites in drug delivery
7.7 Conclusion
References
Chapter 8. Alginate–montmorillonite composite systems as sustained drug delivery carriers
Abstract
8.1 Introduction
8.2 Alginates and related composites in drug delivery system
8.3 Montmorillonite
8.4 Alginate–MMT composite particles
8.5 Conclusion
References
Chapter 9. Ionotropically gelled alginate particles in sustained drug release
Abstract
9.1 Introduction
9.2 Sustained drug release
9.3 Alginates
9.4 Ionotropic gelation of natural polysaccharides
9.5 Insights into the use of ionotropically gelled alginate-based particles for sustained release drug delivery
9.6 Conclusion
References
Chapter 10. Inorganic materials–alginate composites in drug delivery
Abstract
Abbreviations
10.1 Introduction
10.2 Alginates and alginate-based composites in drug delivery
10.3 Inorganic materials–alginate composites
10.4 Conclusion
References
Chapter 11. Particulate matrices of ionotropically gelled alginate- and plant-derived starches for sustained drug release
Abstract
11.1 Introduction
11.2 Alginates
11.3 Starches
11.4 Ionotropically gelled alginate–plant-derived starches composite particles in drug delivery
11.5 Conclusion
References
Chapter 12. Polyelectrolyte complexes of alginate for controlling drug release
Abstract
12.1 Introduction
12.2 Alginate
12.3 Polyelectrolyte complexes
12.4 Alginate–chitosan polyelectrolyte complexes for controlled drug release
12.5 Alginate-cationized gelatin polyelectrolyte complexes for controlled drug release
12.6 Alginate-cationic starch polyelectrolyte complexes for controlled drug release
12.7 Alginate-cationized poly-L-lysine polyelectrolyte complexes for controlled drug release
12.8 Conclusion
References
Chapter 13. Alginate-based hydrogel systems for drug releasing in wound healing
Abstract
13.1 Introduction
13.2 Wounds
13.3 Classification of wounds
13.4 Wound healing
13.5 Wound dressing
13.6 Alginate as wound dressing material
13.7 Alginate-based hydrogels as wound dressings and drug releasing for wound healing
13.8 Future prospects
13.9 Conclusion
References
Chapter 14. Alginate-based scaffolds for drug delivery in tissue engineering
Abstract
14.1 Introduction
14.2 Scaffolds in tissue engineering
14.3 Scaffold fabrication techniques
14.4 Alginates
14.5 Alginates used as tissue engineering scaffold materials
14.6 Various alginate-based drug-releasing scaffolds for tissue regeneration
14.7 Conclusion
References
Chapter 15. Use of alginates for drug delivery in dentistry
Abstract
15.1 Introduction
15.2 History and origin of alginates
15.3 Chemistry of alginates
15.4 Alginates in dentistry
15.5 Insights into the use of alginate-based systems for drug delivery in dentistry
15.6 Conclusion
References
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Marwadi University, Rajkot, Gujarat, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health