Aging and Troponin
Clinical Implications and Uses Beyond Diagnosis
- 1st Edition - August 1, 2026
- Latest edition
- Editors: Gary Tse, Kelvin Yuen Kwong Chan, Leonardo Roever, Giuseppe Biondi-Zoccai
- Language: English
Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This compre… Read more
Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Section I covers the technical aspects of troponin assays, comparing traditional and high-sensitivity assays, and exploring point-of-care testing advancements. It also examines age-related changes and intra- and inter-individual variability in troponin levels. Section II focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity. Section III discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice. Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis is an invaluable resource for researchers, clinicians, and healthcare professionals seeking to understand the impact of aging on troponin levels.
- Explores how aging affects troponin levels and their interpretation in various medical conditions
- Details high-sensitivity assays and point-of-care testing tailored for elderly patients
- Highlights troponin's role in predicting mortality and cardiovascular events in older adults
- Examines troponin variants as indicators of muscle quality and aging-related changes
- Offers strategies for integrating age-adjusted troponin testing into clinical practice
Researchers from biomedical and laboratory fields as well as general and specialist doctors, including pathologists, nurses, biochemists, laboratory scientists and technologists
Section I. Pre-clinical: Technical aspects
1. Traditional Versus High-sensitivity Troponin Assays
2. Point-of-care Troponin Assays
3. Age-related Changes of Troponin
4. Intra-individual Variability in Troponin
5. Inter-individual Variability in Troponin
Section II. Clinical: Diagnosis
6. Troponin As a Biomarker of Cardiac Injury
7. Troponin As a Biomarker of Cardiac Dysfunction in Cancer Patients
8. Effects of Age on Diagnostic Sensitivity and Specificity of Troponin in Patients with Suspected Myocardial Infraction
9. Diagnosis of Acute Myocardial Infarction in Renal Impairment
10. Sex-specific Cut-offs for Diagnosing Myocardial Infarction for Different Age Groups
11. The Impact of Central and Peripheral Haemodynamics on Troponin Levels
Section III. Epidemiological: Prognosis and Model Development
12. Troponin and Age-related Cognitive Decline
13. Troponin and Age-related Renal Decline
14. Troponin As a Prognostic Marker of Mortality in Pulmonary and Heart Disease
15. Troponin in Sepsis
16. Troponin As a Prognostic Marker of Mortality in the General Population
17. Troponin in Acute and Chronic COVID-19 Infections
18. Population Differences in Troponin
19. Troponin As a Marker of Organ and Overall Biological Age
20. Novel Biomedical Engineering Considerations Using Nanosensing to Increase Sensitivity of Troponin Detection
21. Binding of DNA Aptamers to Troponin: Potential Clinical Uses
Section IV. Summary
22. Clinical Applicability: The Impact of Accelerated Diagnostic Protocols Incorporating High-sensitivity Troponin Assay in the Emergency Department
23. Clinical Applicability: Perspectives From the Physician
1. Traditional Versus High-sensitivity Troponin Assays
2. Point-of-care Troponin Assays
3. Age-related Changes of Troponin
4. Intra-individual Variability in Troponin
5. Inter-individual Variability in Troponin
Section II. Clinical: Diagnosis
6. Troponin As a Biomarker of Cardiac Injury
7. Troponin As a Biomarker of Cardiac Dysfunction in Cancer Patients
8. Effects of Age on Diagnostic Sensitivity and Specificity of Troponin in Patients with Suspected Myocardial Infraction
9. Diagnosis of Acute Myocardial Infarction in Renal Impairment
10. Sex-specific Cut-offs for Diagnosing Myocardial Infarction for Different Age Groups
11. The Impact of Central and Peripheral Haemodynamics on Troponin Levels
Section III. Epidemiological: Prognosis and Model Development
12. Troponin and Age-related Cognitive Decline
13. Troponin and Age-related Renal Decline
14. Troponin As a Prognostic Marker of Mortality in Pulmonary and Heart Disease
15. Troponin in Sepsis
16. Troponin As a Prognostic Marker of Mortality in the General Population
17. Troponin in Acute and Chronic COVID-19 Infections
18. Population Differences in Troponin
19. Troponin As a Marker of Organ and Overall Biological Age
20. Novel Biomedical Engineering Considerations Using Nanosensing to Increase Sensitivity of Troponin Detection
21. Binding of DNA Aptamers to Troponin: Potential Clinical Uses
Section IV. Summary
22. Clinical Applicability: The Impact of Accelerated Diagnostic Protocols Incorporating High-sensitivity Troponin Assay in the Emergency Department
23. Clinical Applicability: Perspectives From the Physician
- Edition: 1
- Latest edition
- Published: August 1, 2026
- Language: English
GT
Gary Tse
Gary Tse is a medical scientist focusing on personalized care, health informatics and big data analytics. He is a professor in Hong Kong Metropolitan University and holds a joint position as reader at the University of Kent and public health consultant at the Medway Council in local government, UK. He serves as a professor at the Department of Cardiology and principal investigator at the Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, China. He is a visiting professor at the Faculty of Health and Medical Sciences, University of Surrey, and an honorary associate professor at the School of Pharmacy, University College London. He is an author of more than 500 scientific papers and an expert reviewer for >50 international journals in cardiology, cardiac electrophysiology, cardiovascular biology and epidemiology and five grant bodies from New Zealand, Poland, Sweden and the UK.
Affiliations and expertise
Distinguished Academic Physician-Scientist and Professor, School of Nursing and Health Sciences, Hong Kong Metropolitan University, ChinaKC
Kelvin Yuen Kwong Chan
Dr. Kelvin Yuen Kwong Chan is a distinguished researcher and medical scientist with extensive experience in genomics, prenatal diagnostics, and human disease mechanisms. After post-doctoral training, he served as Research Assistant Professor at The University of Hong Kong’s Department of Pathology. He then held key roles at Tsan Yuk Hospital and Queen Mary Hospital’s Prenatal Diagnostic Laboratory, overseeing prenatal testing services. At the Hong Kong Genome Institute, he led laboratory operations for Hong Kong’s first population-scale human genome project. With over 100 peer-reviewed publications—including in Nature Genetics and Cancer Research—he has over 3,000 citations. Dr. Chan is an active peer reviewer and editorial board member for multiple scientific journals. His research focuses on molecular profiling and genetic variation analysis in human diseases and cancers. He holds several professional memberships and academic appointments, including Honorary Associate Professor at HKU.
Affiliations and expertise
Associate Professor, Diagnostic Sciences, HKMULR
Leonardo Roever
Prof. Dr. Leonardo Roever is a distinguished clinical epidemiologist and healthcare data scientist with a prolific publication record of over 394 articles in high-impact journals such as The Lancet, Nature, and JAMA. He holds degrees from UNIT, UNIFESP, and UFU, including a PhD in Health Sciences and a postdoctoral fellowship in Neurosciences. As Senior Board Member at BMC Medical Research Methodology and a Specialty Chief Editor for Frontiers in Cardiovascular Medicine, he contributes extensively to scientific publishing. His expertise encompasses clinical research, meta-analyses, cardiovascular disease, metabolic syndrome, and global health. Dr. Roever is actively involved in international research networks, serving as CEO of BRAMETIS and collaborating with organizations like MRC and NIHR. With over 105,955 citations, he is recognized as a leading figure in evidence-based medicine, epidemiology, and health informatics.
Affiliations and expertise
Clinical Epidemiologist, Healthcare Data Scientist, Brazilian Evidence-Based Health NetworkGB
Giuseppe Biondi-Zoccai
Dr. Giuseppe Biondi-Zoccai is an Associate Professor of Cardiology at Sapienza University of Rome, based in Latina, Italy. He specializes in advanced cardiology, biostatistics, evidence-based medicine, and cardiovascular imaging, with a focus on heart disease, inflammation, and interventional procedures. A prolific researcher, he has authored over 330 articles and leads the METCARDIO meta-analysis group. His expertise includes hypertension, atherosclerosis, heart failure, and myocardial infarction. Dr. Biondi-Zoccai is a member of the Heart Group of the Cochrane Collaboration and is recognized for his methodological contributions to evidence-based cardiology. His work significantly advances clinical research and systematic reviews in cardiovascular medicine, making him a prominent figure in Italian and international cardiology research.
Affiliations and expertise
Associate Professor, Cardiology, Sapienza University of Rome