
Adverse Effects of Engineered Nanomaterials
Exposure, Toxicology, and Impact on Human Health
- 2nd Edition - February 14, 2017
- Imprint: Academic Press
- Editors: Bengt Fadeel, Antonio Pietroiusti, Anna A. Shvedova
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 9 1 9 9 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 9 4 9 0 - 7
Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineere… Read more

Purchase options

Institutional subscription on ScienceDirect
Request a sales quoteAdverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety.
Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials.
This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population.
- Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field
- Discusses the health implications of experimental data in nanotoxicology
- Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters
This book is intended for those directly involved in the field of nanosafety, namely professionals in toxicology, pharmacology, occupational medicine, clinical medicine and nanomedicine. Workers concerned with safety in the pharmaceutics, cosmetics and public health industries, as well as policy makers developing regulatory frameworks and nanotechnology industries/enterprises
Section A: Engineered nanomaterials: Hazard, exposure, risk assessment
Chapter 1: Bio–Nano Interactions
- Abstract
- Introduction
- Protein Corona on Nanoparticles
- Development of the Protein Corona
- Impact of the NP-Biomolecule Corona on Human Systems
- Nanotoxicity and the Biomolecule Corona
- Conclusions
- Take-Home Messages
- Acknowledgments
Chapter 2: Physicochemical Characterization
- Abstract
- Introduction
- Overview of Key Physicochemical Parameters
- Modalities of Physicochemical Characterization
- Sample Preparation and Dispersion Media
- Data Collection and Interpretation
- Take-Home Messages
- Acknowledgments
- Disclaimer
Chapter 3: Toxicity Tests: In Vitro and In Vivo
- Abstract
- Introduction
- Methods for Visualizing Cellular Uptake and Biodistribution
- Evaluation of Transport and Uptake of ENM In Vitro and In Vivo
- In Vitro Toxicity Tests
- In Vivo Toxicity Testing
- Considerations for Selection of Toxicity Tests: In Vitro/In Vivo Comparison
- Conclusions
- Take-Home Messages
- Acknowledgments
Chapter 4: Computational Approaches
- Abstract
- Introduction
- Challenges in Modeling Nanoparticle Biological Effects
- Examples of Nanotoxicology Modeling Approaches
- Elucidating Interactions Between Nanomaterials and Proteins
- Other Modeling Approaches for Nanotoxicology
- Conclusions
- Take-Home Messages
Chapter 5: Exposure Assessment
- Abstract
- Background
- How can Workers be Exposed to ENMs?
- Exposure Routes
- Characterization of Behavior of ENMs
- Challenges to Assess Exposure to ENMs
- Exposure Assessment of ENMs in Workplaces
- Take-Home Messages
Chapter 6: Biomonitoring
- Abstract
- Introduction
- Issues in the Development of Biomarkers for Engineered Nanomaterials
- Factors Affecting Biomarkers of Exposure
- Biomarkers of Effects
- Genetic and Epigenetic Biomarkers
- Toward Nanospecific and Predictive Biomarkers
- Biomonitoring in Health Surveillance and Epidemiology
- Biomonitoring Programs: Practical and Ethical Considerations
- Conclusions
- Take-Home Messages
Chapter 7: Regulation and Legislation
- Abstract
- Background
- Risk Assessment of Nanomaterials
- Regulation Areas for Nanomaterials
- United States
- European Union
- Korea
- Japan
- Take-Home Messages
- Acknowledgments
- Disclaimer
Chapter 8: Risk Assessment and Risk Management
- Abstract
- Introduction
- Consideration of Exposure for Nanomaterial Risk Assessment
- Nanomaterial Hazard Assessment by Toxicological Properties
- Grouping of Nanomaterials to Streamline Hazard and Risk Assessment
- Consideration of Cellular and Apical Effects for Nanomaterial Grouping
- Nanomaterial Risk Assessment and Risk Management
- Conclusions
- Take-Home Messages
Section B: Engineered nanomaterials: Adverse effects on human health
Chapter 9: Respiratory System, Part One: Basic Mechanisms
- Abstract
- Introduction
- Nanoparticle Deposition and Clearance From the Lungs
- Pulmonary Responses
- Processes and Mechanisms Underlying Particle-Induced Effects in the Pleuro-Pulmonary System
- Conclusions
- Acknowledgments
Chapter 10: Respiratory System, Part Two: Allergy and Asthma
- Abstract
- Allergic Reactions and Asthma
- Engineered Nanoparticles and Allergy
- Carbon Nanotubes and Allergic Pulmonary Inflammation
- Modulation of Allergen-Induced Airway Inflammation by CNTs
- Mechanisms of CNT-Induced/Mediated Allergic Responses
- Conclusions
- Take-Home Messages
- Acknowledgments
- Disclaimer
Chapter 11: Cardiovascular System
- Abstract
- Introduction
- Diagnostic Applications in Cardiovascular Disease
- Particokinetics of Nanomaterials for Diagnostic Use
- Combustion-Derived Nanoparticles in Cardiovascular Disease
- Toxicity of Engineered Nanoparticles in Cardiovascular Disease
- Conclusions
Chapter 12: Neurological System
- Abstract
- Introduction
- ENM Translocation to and Within the Nervous System
- ENM Interactions With Biological Structures Including the Nervous System
- Biotransformation and Persistence of ENMs in the Nervous System
- Adverse Effects of ENMs Related to Nervous System Functions and Disease
- Risk Assessment of Nanomaterials
- Take-Home Messages
Chapter 13: Immune System
- Abstract
- Introduction
- Innate Immune Responses
- The Immune System Strikes Back
- Complement Activation
- Adaptive Immune Responses
- Nanomaterials and Allergies
- Immunosuppression by Nanomaterials
- Definitely Not Innocent Bystanders
- Turning the Tables: Biomedical Applications
- Take-Home Messages
- Acknowledgments
Chapter 14: Endocrine System
- Abstract
- Introduction
- Which Endocrine Organs are Disrupted by NMs?
- How Do NMs Functionally Disrupt Endocrine Organs?
- The Biological Mechanisms of Effects on Organs
- Take-Home Messages
Chapter 15: Skin
- Abstract
- Skin Anatomy and Functions
- Nanoparticle Penetration
- Toxicity Studies
- Take-Home Messages
Chapter 16: Gastrointestinal System
- Abstract
- Introduction
- Conditions and Barriers in the Gastrointestinal Tract
- Uptake of Nanomaterials in the Gastrointestinal Tract
- Potential Toxicity of Nanomaterials in the Gastrointestinal Tract
- Conclusions
- Take-Home Messages
- Acknowledgments
Chapter 17: Reproduction and Development
- Abstract
- Introduction
- Fertility
- Nanoparticles and Developmental Toxicity
- Discussion
- Take-Home Messages
Chapter 18: Genotoxicity and Cancer
- Abstract
- Introduction
- Primary Mechanisms for Genotoxicity
- Secondary Mechanisms for Genotoxicity
- From Genotoxicity to Cancer
- Carbon–Based Nanomaterials
- Metallic Nanoparticles
- Metal Oxides
- Conclusions and Future Directions
- Edition: 2
- Published: February 14, 2017
- No. of pages (Hardback): 486
- No. of pages (eBook): 486
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128091999
- eBook ISBN: 9780128094907
BF
Bengt Fadeel
AP
Antonio Pietroiusti
AS