Advances in Virus Research

Series Page

Contributors

In Memoriam

Aaron Shatkin (1934–2012)

Chapter One. Regulation of Retroviral Polyadenylation

Abstract

Abbreviations

1 Cellular Polyadenylation

2 Retroviral Long Terminal Repeats

3 Retroviruses with the Poly(A) Signal Located in the U3 Region

4 Retroviruses Encoding the Poly(A) Signal in the R Region

5 Conclusions

Acknowledgments

References

Chapter Two. Open Questions About Giant Viruses

Abstract

1 Background

2 The Traditional View: Viruses Started Small, Got Bigger

3 Genome Reduction: A Neutral Ratchet Wheel Generating the Diversity of Large DNA Viruses

4 Speculation on the Nature of the Giant Virus Ancestor

Acknowledgments

References

Chapter Three. Assembly and Budding of Negative-Strand RNA Viruses

Abstract

1 Introduction

2 Virion Structure: The Final Product

3 Steps in Assembly of Virus Budding Sites

4 Role of Membrane Microdomains in Assembly of Envelope Glycoproteins

5 Assembly of Viral Matrix Proteins

6 Selection of Nucleocapsids

7 Late Budding Functions and Virus Release

8 Back to the Beginning: How is Assembly Initiated?

9 Perspectives for the Future

References

Chapter Four. Arthropod-Borne Flaviviruses and RNA Interference: Seeking New Approaches for Antiviral Therapy

Abstract

1 Introduction

2 The RNA Interference Mechanism and its Antiviral Effects

3 Arthropod-Borne Flaviviruses

4 RNAi and the Mosquito Vector

5 The Interplay Between Arthropod-Borne Flaviviruses and the Endogenous Host Cell RNAi Pathway

6 Conclusions and Challenges

Acknowledgments

References

Index