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Advances in Protein Chemistry and Structural Biology
- 1st Edition, Volume 138 - January 11, 2024
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 4 2 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 4 3 - 9
Advances in Protein Chemistry and Structural Biology, Volume 138 covers reviews of methodology and research in all aspects of protein chemistry, including purifi… Read more
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Request a sales quoteAdvances in Protein Chemistry and Structural Biology, Volume 138 covers reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design. Chapters in this release include Proteomic Applications in Identifying Protein-Protein Interactions, Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach, Proteomics provides insights into theranostic potential of extracellular vesicles, Towards a shareable functional analysis of the structural proteome, Functional unfoldomics, In-silico Network Pharmacology Study on Glycyrrhiza glabra: Analyzing the Immune-Boosting phytochemical properties of Siddha Medicinal Plant against COVID-19, and more.
Other chapters cover In silico Network Pharmacology Analysis and Molecular Docking Validation of Swasa Kudori for Screening Druggable Phytoconstituents of Asthma, Proteomics and Genomics Insights on Malignant Osteosarcoma, Application of functional proteomics in understanding RNA Virus-Mediated Infection, Biofilm proteome of Staphylococcus aureus: implications for therapeutic interventions to biofilm-associated infections, A computational pipeline elucidating functions of conserved hypothetical Trypanosoma cruzi proteins based on public proteomic data, Functional Proteomics based on Protein Microarray Technology for Biomedical Research, and an Analysis of endoglucanases production using proteomics and metatranscriptomics.
Other chapters cover In silico Network Pharmacology Analysis and Molecular Docking Validation of Swasa Kudori for Screening Druggable Phytoconstituents of Asthma, Proteomics and Genomics Insights on Malignant Osteosarcoma, Application of functional proteomics in understanding RNA Virus-Mediated Infection, Biofilm proteome of Staphylococcus aureus: implications for therapeutic interventions to biofilm-associated infections, A computational pipeline elucidating functions of conserved hypothetical Trypanosoma cruzi proteins based on public proteomic data, Functional Proteomics based on Protein Microarray Technology for Biomedical Research, and an Analysis of endoglucanases production using proteomics and metatranscriptomics.
- Cover image
- Title page
- Copyright
- Table of Contents
- Contributors
- Chapter One: Proteomic applications in identifying protein-protein interactions
- Abstract
- Abbreviations
- 1 Introduction
- 2 Isolation of protein complexes
- 3 Proteomics enters the PPI field
- 4 Whole proteome screening for PPIs
- 5 Protein-protein interaction databases
- 6 Challenges in generating global PPI maps
- 7 Conclusions
- References
- Chapter Two: Functional proteomics based on protein microarray technology for biomedical research
- Abstract
- 1 Introduction
- 2 Proteomic technologies
- 3 Microarrays applications
- 4 Conclusions and future perspectives
- References
- Chapter Three: Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach
- Abstract
- 1 Human translation elongation factors
- 2 eEF1A1 and eEF1A2
- 3 Difference in physical properties of eEF1A1 and eEF1A2
- 4 Principles of research
- 5 Common moonlighting functions of eEF1A1 and eEF1A2
- 6 Potential novel functions of the eEF1A1 isoform
- 7 Potential novel functions of eEF1A2 isoform
- 8 Concluding remarks
- Acknowledgments
- References
- Chapter Four: Proteomics provides insights into the theranostic potential of extracellular vesicles
- Abstract
- 1 Introduction
- 2 Advances in proteomics: Unveiling biological complexity, disease mechanisms, and personalized medicine
- 3 The protein cargoes of EVs are influenced by different factors
- 4 More studies are needed; Available databases
- 5 Conclusion
- References
- Chapter Five: Towards a structural and functional analysis of the immunoglobulin-fold proteome
- Abstract
- 1 Introduction to the immunoglobulin fold
- 2 Ig fold proteome in physiology and disease
- 3 Applications of the Ig fold domains
- Acknowledgments
- References
- Chapter Six: Functional unfoldomics: Roles of intrinsic disorder in protein (multi)functionality
- Abstract
- 1 Most of the textbook knowledge about proteins is incomplete: introducing the protein intrinsic disorder phenomenon
- 2 Structural complexity of intrinsic disorder
- 3 Complexity of the disorder-based functional code and protein structure-function continuum
- 4 Major disorder-based biological functions
- 5 Interaction specialists: intrinsic disorder is advantageous for interactions
- 6 Disorder-based foldable binding sites of proteins: static disorder-based interactions
- 7 Fuzzy or dynamic complexes: binding with minimal folding or with no folding at all
- 8 Liquid-liquid phase separation, membrane-less organelles, and intrinsic disorder
- 9 Concluding remarks
- References
- Chapter Seven: Analysis of endoglucanases production using metatranscriptomics and proteomics approach
- Abstract
- 1 Introduction
- 2 Application of endoglucanases
- 3 Metatranscriptomic approach
- 4 Proteomics tool for analyzing endoglucanase production
- 5 Conclusion
- Acknowledgement
- References
- Chapter Eight: In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19
- Abstract
- Abbreviations
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- 5 Conclusion
- References
- Chapter Nine: In silico network pharmacology analysis and molecular docking validation of Swasa Kudori tablet for screening druggable phytoconstituents of asthma
- Abstract
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- References
- Chapter Ten: Proteomics and genomics insights on malignant osteosarcoma
- Abstract
- 1 Introduction
- 2 Types of osteosarcoma
- 3 Bone metastasis
- 4 Etiology of osteosarcoma
- 5 Epidemiology of osteosarcoma
- 6 Epigenetic of osteosarcoma
- 7 Gene mutation
- 8 Molecular biology and pathogenesis of osteosarcoma
- 9 Pathway involved in osteosarcoma
- 10 Biomarker of osteosarcoma
- 11 Proteomics in osteosarcoma
- 12 Diagnosis and staging
- 13 Cancer treatment caused bone loss
- 14 Future perspective
- References
- Chapter Eleven: Application of functional proteomics in understanding RNA virus-mediated infection
- Abstract
- 1 Introduction
- 2 Functional proteomics—overview
- 3 Methodologies of functional proteomics
- 4 Implementation of functional proteomics in RNA viral infection study
- 5 Therapeutic application and proteomics
- 6 Diagnosis
- 7 Detection
- 8 Conclusion and perspectives
- References
- Chapter Twelve: The biofilm proteome of Staphylococcus aureus and its implications for therapeutic interventions to biofilm-associated infections
- Abstract
- 1 Introduction
- 2 Role of proteins in S. aureus biofilm formation
- 3 Regulation of biofilm phenotype in S. aureus
- 4 Anti-biofilm therapeutic interventions
- 5 Conclusion
- References
- Chapter Thirteen: A computational pipeline elucidating functions of conserved hypothetical Trypanosoma cruzi proteins based on public proteomic data
- Abstract
- 1 Introduction
- 2 Results
- 3 Discussion
- 4 Conclusions
- 5 Material and methods
- 6 Uniform manifold approximation and projection (UMAP) and clusterization analysis
- 7 Gene ontology enriched terms
- 8 Three-dimensional structure generation and analysis
- 9 Conserved protein domain mapping
- References
- No. of pages: 488
- Language: English
- Edition: 1
- Volume: 138
- Published: January 11, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443193422
- eBook ISBN: 9780443193439
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Advances in Protein Chemistry and Structural Biology on ScienceDirect