Limited Offer
Advances in Protein Chemistry and Structural Biology
- 1st Edition, Volume 84 - August 13, 2011
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 8 6 4 8 3 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 8 6 4 8 4 - 0
Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering review… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quotePublished continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation.
- Covers reviews of methodology and research in all aspects of protein chemistry
- Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics
Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists
Nucleic acid-mediated protein aggregation and assembly
I. Introduction
II. Nucleic Acid-Mediated Aggregation of Amyloid Proteins
III. Nucleic Acid Sequestration to Pathological Tissues
IV. Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids
V. Summary
Aggregation, stability, and formulation of human antibody therapeutics
I. Introduction
II. Expression of Human Monoclonal Antibodies and Antibody Fragments
III. Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal Antibodies
IV. Addressing Aggregation and Increasing Stability of Monoclonal Antibodies
Lysozyme
I. Introduction
II. Amyloid and Amyloidosis
III. Human Lysozyme
IV. Aggregation of Hen Lysozyme In Vitro
V. Recovery and Purification of Lysozyme from Inclusion Bodies
VI. Inhibition of Lysozyme Aggregation
VII. Future Perspectives
Protein aggregation in a membrane environment
I. Introduction
II. The Role of Electrostatics in Membrane-Mediated Protein Aggregation
III. Hydrophobic Effect as Driving Force for Protein Aggregation
IV. Hydrogen-Bonding as Determinant of Protein Aggregation Propensity
V. Experimental Techniques Used to Study Protein Aggregation
VI. Concluding Remarks
Contactins
I. Introduction
II. Genetic Implication of CNTN4, CNTN5, and CNTN6 in Neurodevelopment
III. Expression of Contactins During Brain Development
IV. Phenotypes in Contactin Null-Mutants
V. Structural Architecture of Contactins
VI. Protein–Protein Interactions Mediated by Contactins
VII. Final Remarks
Author Index
Subject Index
I. Introduction
II. Nucleic Acid-Mediated Aggregation of Amyloid Proteins
III. Nucleic Acid Sequestration to Pathological Tissues
IV. Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids
V. Summary
Aggregation, stability, and formulation of human antibody therapeutics
I. Introduction
II. Expression of Human Monoclonal Antibodies and Antibody Fragments
III. Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal Antibodies
IV. Addressing Aggregation and Increasing Stability of Monoclonal Antibodies
Lysozyme
I. Introduction
II. Amyloid and Amyloidosis
III. Human Lysozyme
IV. Aggregation of Hen Lysozyme In Vitro
V. Recovery and Purification of Lysozyme from Inclusion Bodies
VI. Inhibition of Lysozyme Aggregation
VII. Future Perspectives
Protein aggregation in a membrane environment
I. Introduction
II. The Role of Electrostatics in Membrane-Mediated Protein Aggregation
III. Hydrophobic Effect as Driving Force for Protein Aggregation
IV. Hydrogen-Bonding as Determinant of Protein Aggregation Propensity
V. Experimental Techniques Used to Study Protein Aggregation
VI. Concluding Remarks
Contactins
I. Introduction
II. Genetic Implication of CNTN4, CNTN5, and CNTN6 in Neurodevelopment
III. Expression of Contactins During Brain Development
IV. Phenotypes in Contactin Null-Mutants
V. Structural Architecture of Contactins
VI. Protein–Protein Interactions Mediated by Contactins
VII. Final Remarks
Author Index
Subject Index
- No. of pages: 216
- Language: English
- Edition: 1
- Volume: 84
- Published: August 13, 2011
- Imprint: Academic Press
- Hardback ISBN: 9780123864833
- eBook ISBN: 9780123864840
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Advances in Protein Chemistry and Structural Biology on ScienceDirect