Advances in Protein Chemistry and Structural Biology

Nucleic acid-mediated protein aggregation and assembly
I. Introduction
II. Nucleic Acid-Mediated Aggregation of Amyloid Proteins
III. Nucleic Acid Sequestration to Pathological Tissues
IV. Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids
V. Summary

Aggregation, stability, and formulation of human antibody therapeutics
I. Introduction
II. Expression of Human Monoclonal Antibodies and Antibody Fragments
III. Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal Antibodies
IV. Addressing Aggregation and Increasing Stability of Monoclonal Antibodies

Lysozyme
I. Introduction
II. Amyloid and Amyloidosis
III. Human Lysozyme
IV. Aggregation of Hen Lysozyme In Vitro
V. Recovery and Purification of Lysozyme from Inclusion Bodies
VI. Inhibition of Lysozyme Aggregation
VII. Future Perspectives

Protein aggregation in a membrane environment
I. Introduction
II. The Role of Electrostatics in Membrane-Mediated Protein Aggregation
III. Hydrophobic Effect as Driving Force for Protein Aggregation
IV. Hydrogen-Bonding as Determinant of Protein Aggregation Propensity
V. Experimental Techniques Used to Study Protein Aggregation
VI. Concluding Remarks

Contactins
I. Introduction
II. Genetic Implication of CNTN4, CNTN5, and CNTN6 in Neurodevelopment
III. Expression of Contactins During Brain Development
IV. Phenotypes in Contactin Null-Mutants
V. Structural Architecture of Contactins
VI. Protein–Protein Interactions Mediated by Contactins
VII. Final Remarks
Author Index
Subject Index