
Advances in Protein Chemistry and Structural Biology
- 1st Edition, Volume 80 - December 7, 2010
- Imprint: Academic Press
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 8 1 2 6 4 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 8 1 2 6 5 - 0
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to bu… Read more

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Request a sales quoteStructural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.
While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
- Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
- Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission
- Proteomics technologies for the global identification and quantification of proteins
- Targeted metabolomics and mass spectrometry
- Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling
- Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling
- Positive and Negative Modulation of Nicotinic Receptors
- Sonochemically Born Proteinaceous Micro- and Nanocapsules
Ian A. Brewis and P. Brennan
E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths
Tatyana Karabencheva and Christo Christov
Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees
Hugo R. Arias
Elena D. Vassileva and Neli S. Koseva
- Edition: 1
- Volume: 80
- Published: December 7, 2010
- No. of pages (Hardback): 296
- No. of pages (eBook): 296
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780123812643
- eBook ISBN: 9780123812650
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