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Advances in Protein Chemistry and Structural Biology

  • 1st Edition, Volume 80 - December 7, 2010
  • Latest edition
  • Editor: Rossen Donev
  • Language: English

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to bu… Read more

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Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Key features

  • Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
  • Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of contents

  1. Proteomics technologies for the global identification and quantification of proteins

    2. Ian A. Brewis and P. Brennan

  2. Targeted metabolomics and mass spectrometry

    3. E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths

  3. Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling

    4. Tatyana Karabencheva and Christo Christov

  4. Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling

    5. Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees

  5. Positive and Negative Modulation of Nicotinic Receptors

    6. Hugo R. Arias

  6. Sonochemically Born Proteinaceous Micro- and Nanocapsules

Elena D. Vassileva and Neli S. Koseva

Product details

  • Edition: 1
  • Latest edition
  • Volume: 80
  • Published: December 7, 2010
  • Language: English

About the editor

RD

Rossen Donev

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UK

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