Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics of North America

1st Edition, Volume 51-3 - June 26, 2024
Editors: Jeffrey M. Holzbeierlein, Philippe E. Spiess
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 2 4 6 8 6 - 9
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 4 6 8 7 - 6

In this issue of Urologic Clinics of North America, guest editors Drs. Jeffrey M. Holzbeierlein and Philippe E. Spiess bring their considerable expertise to the topic of Advanc… Read more

Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics of North America

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In this issue of Urologic Clinics of North America, guest editors Drs. Jeffrey M. Holzbeierlein and Philippe E. Spiess bring their considerable expertise to the topic of Advances in Penile and Testicular Cancer. Top experts in the field provide important clinical updates on the management of penile and scrotal cancer, discuss the current standards of care using evidence-based treatment guidelines, and provide insight on emerging discoveries. This issue provides critical information and updates needed to improve outcomes in patients with diseases that urologists do not see on a daily basis.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One
Key points
Introduction
Identifying the 2 types of squamous cell carcinoma of the penis
Human papillomavirus-associated carcinogenesis
Human papillomavirus-independent carcinogenesis
Preneoplastic squamous lesions
The invasive squamous cell carcinoma of the penis
Guiding the urologists’ hand: Present and future decision-making in squamous cell carcinoma of the penis with pathology-driven data
Summary
Clinics care points
Psychosocial Impact of Penile Cancer: An Unmet Need
Key points
Introduction
Summary
Clinics care points
Management of Bulky Inguinal and Pelvic Lymph Nodes
Key points
Introduction/history/definitions/background
Lymph node staging
Management of inguinal lymph nodes
Adjuvant therapy
Summary
Overview of Systemic Therapies in Penile Cancer
Key points
Introduction
Summary
Clinics care points
Immune-based Therapies for Penile Cancer
Key points
Introduction
Unmet need in advanced penile squamous cell carcinoma
Rational for immunotherapy and current trials landscape in penile squamous cell carcinoma
Factors influencing immunotherapy efficacy
Genomic factors
Summary
Clinics care points
New Therapeutic Horizons for Advanced or Metastatic Penile Cancer
Key points
Introduction
Current standard of care
Areas of current exploration
Human papillomavirus-directed therapies
Adoptive cellular therapy
Antibody–drug conjugates
Early integration of palliative care services
Summary
Clinics care points
Update on the Management of Low-stage Seminoma
Key points
Introduction
Evaluation and staging
Management of clinical stage I seminoma
Management of clinical stage IIA and IIB seminomas
Future directions
Summary
Clinics care points
MicroRNA for Prediction of Teratoma and Viable Germ Cell Tumor after Chemotherapy
Key points
Introduction
Discussion
Summary
Clinics care points
Contemporary Role of Radiation Therapy in Testicular Cancer
Key points
Introduction
Management
Review of radiation therapy considerations and contemporary developments
Ongoing clinical trial related to radiation treatment
Summary
Clinics care points
Retroperitoneal Lymph Node Dissection: Perioperative Management and Updates on Surgical Techniques
Key points
Introduction
Perioperative preparation
Surgical approach
Complications
Summary
Clinics care points
Regionalization of Testis Cancer Care—Is It Necessary?
Key points
Introduction
Definition of regionalization
Necessity of regionalization
Radical orchiectomy
Pathohistology
Management of clinical stage I disease
Metastatic testicular germ cell tumors
Postchemotherapeutic retroperitoneal lymph node dissection
Economic issues
Summary and future perspectives
Clinics care points
Testicular Cancer Survivorship and Fertility Preservation
Key points
Introduction
Preface
Causes of infertility due to therapy
Fertility preservation prior to treatment
Fertility preservation during treatment
Fertility preservation after treatment
Summary
Clinics care points

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Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics of North America

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Jeffrey M. Holzbeierlein

Philippe E. Spiess