Advances in Oncology, 2023

1st Edition, Volume 3-1 - April 13, 2023
Imprint: Elsevier
Editor: Leonidas C. Platanias
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 2 7 0 - 9
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 8 2 7 1 - 6

Advances in Oncology reviews the year’s most important findings and updates within the field in order to provide practicing oncologists with the current clinical information they… Read more

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Advances in Oncology reviews the year’s most important findings and updates within the field in order to provide practicing oncologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Leonidas C. Platanias, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in oncology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care.

Cover image
Title page
Table of Contents
Copyright
Editorial Board
Contributors
Preface
SECTION I: RADIATION ONCOLOGY
De-escalation for Human Papillomavirus–Associated Oropharyngeal Cancer: A Comprehensive Review
Key points
Introduction
Deescalation strategies
Harm-reduction strategies
Summary
Clinics care points
Treatment of Endometrial Cancer: Updates and Future Directives
Key points
Surgical updates
Radiotherapy updates
Chemoradiotherapy updates
Molecular classification of endometrial cancer
Systemic therapy updates
Clinics care points
Disclosure
SECTION II: SURGICAL ONCOLOGY
Remote Telemonitoring and Telehealth in Surgical Oncology
Key points
Introduction
Thoracic surgery
Colorectal surgery
Breast surgery
Hepatobiliary surgery
Summary
Clinics care points
Financial conflicts of interest/sources of funding
Management of In-Transit Metastatic Melanoma
Key points
Introduction
Initial presentation and diagnosis
Management
Summary
Fundnig
Clinics care points
Contemporary Management of Merkel Cell Carcinoma
Key points
Introduction
Discussion
Treatment
Summary
Clinics care points
Disclosure
SECTION III: GYNECOLOGIC ONCOLOGY
Mitogen-Activated Protein Kinase Driven Rare Gynecologic Cancers and Evolving Therapeutic Targets
Key points
Low-grade serous ovarian cancer overview
Areas of active investigation
Mesonephric adenocarcinoma and mesonephric-like adenocarcinoma (mesonephric neoplasms) overview
Treatment of primary and recurrent mesonephric and mesonephric-like adenocarcinomas
Summary
Clinics care points
Declaration of Interests
Funding
Advances in Cervical Cancer
Key points
Introduction
Updated staging
Surgical management
Adjuvant treatment of early-stage cervical cancer
Primary treatment of locally advanced cervical cancer
Metastatic and Recurrent Cervical Cancer
Summary
Clinics care points
SECTION IV: PEDIATRIC ONCOLOGY
Advances in Pediatric Hodgkin Lymphoma with an Eye on Disparities and Vulnerable Populations
Key points
Introduction
Epidemiology and risk factors
Approach to treatment
New approaches to evaluating risk and measuring response
Chemotherapeutic clinical trial advances with brentuximab
Approach to refractory/relapsed Hodgkin lymphoma
Hodgkin lymphoma outcomes in vulnerable populations
Future directions
Clinics care points
Declaration of Interests
SECTION V: NEURO-ONCOLOGY
Advances in Blood-Brain Barrier Disruption to Facilitate Drug Delivery for Infiltrative Gliomas
Key points
Introduction
Mechanism of action and technical considerations
Safety and feasibility of low-intensity pulsed ultrasound/microbubble-mediated blood–brain barrier opening in humans
Evidence for enhanced drug delivery
Current clinical trials
Concluding remarks and future considerations
Clinics care points
Disclosures
Updates on Role for and Efficacy of Laser Interstitial Thermal Therapy in the Management of Brain Tumors
Key points
Introduction
Recent developments
Summary
Clinics care points
Disclosure
The Microbiome and Central Nervous System Tumors
Key points
Introduction
The gut–brain–axis
Clinical translation
Clinics care points
SECTION VI: HEMATOLOGICAL ONCOLOGY
Moving Toward a Chemotherapy-Free Approach for Philadelphia-Chromosome-Positive Acute Lymphoblastic Leukemia
Key points
Introduction
Chemotherapy-based approaches
Chemotherapy-free approaches
Future directions and unanswered questions
Summary
Clinics care points
Disclosure
Inherited Predisposition to Hematopoietic Malignancies: Advances Made in the Diagnosis and Management of Hereditary Hematopoietic Malignancies in the Era of Next-Generation Sequencing Technologies
Key points
Introduction
Prevalence of hereditary hematopoietic malignancies
Clinical indications for a hereditary hematopoietic malignancy evaluation
Biologically “enriched” populations—which patient populations are at the highest risk for hereditary hematopoietic malignancies?
Diagnostic maneuvers for hereditary hematopoietic malignancies
Clinical surveillance of unaffected carriers of hereditary hematopoietic malignancy–related germline mutations
Summary
Clinics care points
SECTION VII: URO-ONCOLOGY
The Future of Radioligand Therapies in Metastatic Castrate-Resistant Prostate Cancer
Key points
Introduction
Radium-223 dichloride
Lutetitium-177-prostate-specific membrane antigen-617
225-Actinium-prostate-specific membrane antigen-617
Other novel radioligand therapies in development
Emerging radioligand therapies combinations
Discussion
Summary
Disclosures
Clinics care points
The Future of Antibody–Drug Conjugates in Urothelial Cancer: New Indications and Novel Targets
Key points
Introduction
Background on urothelial cancer
Antibody–drug conjugates
Antibody-drug conjugates in urothelial cancer
Future directions
New combinations
Summary
Clinics care points
SECTION VIII: GASTROINTESTINAL ONCOLOGY
Targeting Rat Sarcoma Viral Oncogene Homolog for Treatment of Gastrointestinal Cancers
Key points
Introduction
Rat sarcoma viral oncogene homolog signaling
Rat sarcoma viral oncogene homolog mutations in gastrointestinal cancers
Early attempts to target rat sarcoma viral oncogene homolog-mutated cancers
Direct rat sarcoma viral oncogene homolog inhibitors targeting KRASG12C
Treatment combinations with KRASG12C inhibitors
Targeting rat sarcoma viral oncogene homolog indirectly
Other approaches targeting rat sarcoma viral oncogene homolog-mutated cancers
Summary
Clinics care points
Disclosure
Recent Clinical Advances in Rare Gastrointestinal Tumors: Anal, Small Intestine, and Appendix Cancers
Key points
Anal cancer
Summary
Small-bowel adenocarcinoma
Future directions
Summary
Cancers of the appendix
Future directions
Summary
Clinics care points
COI/disclosures
Gastrointestinal Cancers and the Link to the Microbiome
Key points
Introduction to the microbiome
Microbiome’s role in carcinogenesis
Links between specific gastrointestinal cancers and the microbiome
Linking gastrointestinal cancer therapy to the microbiome
Summary
Clinics care points
Disclosure

Life Sciences

Physical Sciences & Engineering

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Advances in Oncology, 2023

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Leonidas C. Platanias

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