Advances in Oncology, 2022

1st Edition, Volume 2-1 - May 10, 2022
Editor: Leonidas C. Platanias
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 6 9 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 6 7 0 - 0

Advances in Oncology reviews the year’s most important findings and updates within the cancer field for the practicing oncologist. A distinguished editorial board, led by Dr.… Read more

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Advances in Oncology reviews the year’s most important findings and updates within the cancer field for the practicing oncologist. A distinguished editorial board, led by Dr. Leonidas C. Platanias, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in oncology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care.

Cover image
Title page
Table of Contents
Copyright
Editorial Board
Contributors
Preface
SECTION I: RADIATION ONCOLOGY
Opportunities and Advances in the use of Proton Radiotherapy for Management of Central Nervous System and Base of Skull Tumors
Key points
Introduction
Low-grade gliomas
High-grade gliomas
Meningiomas
Medulloblastoma
Chordoma
Vestibular schwannomas
Pituitary adenomas
Discussion
Summary
Clinics care points
Breast Cancer-Related Lymphedema: Causes, Detection, Prevention, and Treatment
Key points
Introduction
Pathophysiology
Risk factors for the development of breast cancer-related lymphedema
Nonsurgical treatment of breast cancer-related lymphedema
Surgical management of breast cancer-related lymphedema
Summary
Clinics care points
Updates in Adjuvant Therapy for High-Risk and Locally Advanced Endometrial Cancer
Key points
Introduction
Trials of adjuvant therapy for early-stage disease
Trials of adjuvant therapy for locally advanced disease
Advent of intensity-modulated radiation therapy
Recent trials of adjuvant therapy for high-risk and locally advanced disease
Discussion
Summary
Clinics care points
SECTION II: SURGICAL ONCOLOGY
Updates on Neoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Adenocarcinoma
Key points
Introduction
Rationale for neoadjuvant therapy in resectable and borderline resectable pancreatic adenocarcinoma
Neoadjuvant therapy
Updates in preoperative therapy for resectable and borderline resectable pancreatic adenocarcinoma
Summary
Clinics care points
Neoadjuvant Chemotherapy for Nonmetastatic Breast Cancer: How Response Impacts Locoregional and Adjuvant Systemic Therapy Decision Making
Key points
Introduction
Surgical downstaging
Trials to tailor locoregional therapy after neoadjuvant chemotherapy
Assessing in vivo sensitivity: moving toward a refined approach for both escalation and de-escalation of systemic therapy
Summary
Funding source
Clinics care points
Contemporary Multimodal Management of Primary Retroperitoneal Sarcomas
Key points
Introduction
General content
Summary
Clinics care points
SECTION III: MEDICAL ONCOLOGY
NTRK Inhibitors in Adult Patients with Solid Tumors
Key points
Introduction
Physiology of TRK receptors
Oncogenic properties of NTRK fusions, downstream pathways, and detection
First-generation NTRK inhibitors
Resistance mechanisms and second-generation inhibitors
Future directions
Clinics care points
Disclosure
Geriatric Assessments: Tools for Every Oncologist to Stage the Aging When Caring for Older Adults with Cancer
Key points
Introduction
Discussion
Summary
Clinics care points
SECTION IV: GYNECOLOGIC ONCOLOGY
The Landscape of Personalized Medicine in Gynecologic Cancer
Key points
Introduction
Discussion
Summary
Clinics care points
Sentinel Lymph Node Sampling in Endometrial Cancers
Key points
Technique development and optimization
The accuracy of sentinel lymph node biopsy for endometrial cancer
Future challenges and questions
Summary
Clinics care points
Health Care Disparities in Gynecologic Oncology
Key points
Introduction
Endometrial cancer
Ovarian cancer
Cervical cancer
Clinical trial participation and enrollment
Addressing health disparities in gynecologic cancer care
Clinics care points
SECTION V: NEURO-ONCOLOGY
Circulating Tumor Cells and Cell-free Tumor DNA in Evaluation and Management of Gliomas: Current Evidence and Potential Future Clinical Use
Key points
Introduction
Summary
Disclosure
Clinical Trials of Oncolytic Viruses in Glioblastoma
Key points
Introduction
Clinical experience using oncolytic viruses in glioblastoma
Discussion
Disclosure
SECTION VI: HEMATOLOGICAL ONCOLOGY
Moving Toward a Cure in Multiple Myeloma: Eradication of Measurable Residual Disease
Key points
Introduction
Defining the absence of disease
Exceptional responders as candidates for functional care
Impact of maintenance on MRD-negativity
MRD adaptive designs to identify functional cures
The myth of the plateau
Future directions to increase the cure fraction in multiple myeloma
Conflicts of interest
Optimizing Hematopoietic Cellular Transplantation in Older Adults with Hematologic Malignancies
Key points
Introduction
Age and posthematopoietic cellular transplantation outcomes
Optimizing older adults for transplant
Future directions and conclusions
Clinics care points
Disclosures
Advances in Janus-Associated Kinase Inhibitor-Based Therapies for Philadelphia Chromosome–Negative Myeloproliferative Neoplasms
Key points
Introduction
Ruxolitinib
Fedratinib
Limitations of current Janus-associated kinase inhibitors
Investigational Janus-associated kinase inhibitors
Janus-associated kinase inhibitor-based combination strategies
Discussion
Summary
Clinics care points
SECTION VII: URO-ONCOLOGY
Deoxyribonucleic Acid Damage Response Defects: Clinical Implications and the Role of Poly-ADP Ribose Polymerase Inhibitors in Genitourinary Cancers and Beyond
Key points
Introduction
The role of deoxyribonucleic acid damage response-directed therapy
Poly-ADP ribose polymerase and poly-ADP ribose polymerase inhibitors
Combination therapies using poly-ADP ribose polymerase inhibitors
The role of poly-ADP ribose polymerase inhibitors in the management of genitourinary cancers
Role of deoxyribonucleic acid damage response defect as a biomarker
Future directions
Summary
Clinics care points
Conflict of interest
Clinical Trial Considerations for Bladder Preservation in Muscle-Invasive Bladder Cancer
Key points
Introduction
Defining bladder sparing/preservation
Randomization and control arms
Discussion
Wish list for best practices:
Disclosures
SECTION VIII: GASTROINTESTINAL ONCOLOGY
Total Neoadjuvant Strategies for Locally Advanced Rectal Cancer
Key points
Introduction
General content
Summary
Disclosure
The Changing Demographics of Colorectal Cancer: Rising Incidence in Younger Individuals
Key points
Introduction
Epidemiology of early-onset colorectal cancer
Characteristics of early-onset colorectal cancer
Molecular profiles of early-onset colorectal cancer
Risk factors for early-onset colorectal cancer
Screening, management, and outcomes of early-onset colorectal cancer
Summary
Clinics care points
Disclosures

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Advances in Oncology, 2022

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Leonidas C. Platanias