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Advances in Nanotechnology-Based Drug Delivery Systems

1st Edition - June 6, 2022

Editors: Anupam Das Talukdar, Satyajit Dey Sarker, Jayanta Kumar Patra

Paperback ISBN:

9 7 8 - 0 - 3 2 3 - 8 8 4 5 0 - 1

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 9 0 4 1 4 - 8

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of… Read more

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Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine.

This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Preface
Chapter 1 Nanotechnology: Scopes and various aspects of drug delivery
1.1 Introduction
1.2 Design of nanotechnology – rooted drug delivery systems
1.3 Liposomes
1.4 Polymeric nanocarriers
1.5 Dendrimer-based nanocarriers
1.6 Quantum dots (QDs)
1.7 Carbon nanotubes (CNTs)
1.8 Miscellaneous types of NPs (e.g., magnetic NPs, silica NPs, metallic NPs)
1.9 Magnetic nanoparticles
1.10 Silica nanoparticles
1.11 Metallic nanoparticles
1.12 Discussion
1.13 Conclusion
References
Chapter 2 Methods for nanoparticle synthesis and drug delivery
2.1 Introduction
2.2 Classification of techniques for synthesis of nanomaterials
2.3 Functionalization strategies
2.4 Mechanism of functionalization
2.5 Some fabrication techniques for nanodrug delivery system
2.6 Selection of nanomaterials in drug delivery
2.7 Conclusion
2.8 Declaimers
References
Chapter 3 Characterization of nanoparticles
3.1 Introduction
3.2 Characterization of nanoparticles
3.3 Conclusions
Acknowledgment
References
Chapter 4 Stability of therapeutic nano-drugs during storage and transportation as well as after ingestion in the human body
4.1 Introduction
4.2 Factors contributing to the stability of nanoparticles
4.3 Influence of the type of nanoparticle and core material on the stability
4.4 Improving the stability of nanoparticles by appropriate preparation methods
4.5 Shelf-life of material
4.6 Contribution of stabilizers in the storage of functional nanoparticles
4.7 Ingestion of nanoparticles and their fate
4.8 Transportation of therapeutic nanoparticles
4.9 Influence of biological barriers on nanoparticle transportation
4.10 Receptor-mediated delivery
4.11 Summary
Acknowledgments
Abbreviations
References
Chapter 5 Advancements in nanophyto formulations
5.1 Introduction
5.2 Nanomedicine
5.3 Nanoherbal medicine
5.4 Advantages of nanomedicine
5.5 Nanotechnology in various medical disciplines
5.6 Herbal nanomedicines and their advantages
5.7 Conclusions
References
Chapter 6 Clinical potential of nanotechnlogy as smart therapeutics: A step toward targeted drug delivery
6.1 Inception of nanobiotechnology
6.2 Nanodrug delivery combating various clinical diseases
6.3 Nanodrug and COVID-19 outbreak: Recent highlights into the nanotechnology approach
6.4 Conclusion
6.5 Conflict of Interest
Acknowledgement
References
Chapter 7 Nanotechnology and oral health
7.1 Introduction
7.2 Nanodentistry
7.3 Applications of nanotechnology in oral health
7.4 Conclusions
Acknowledgment
References
Chapter 8 Bone tissue engineering using nanotechnology based drug delivery system
8.1 Introduction
8.2 Types of Nanomaterials
8.3 Inorganic nanomaterials
8.4 Polymeric nanoparticles
8.5 Systems of nanodrugs delivery and its usages in orthopedics
8.6 Nanoparticles-based drug delivery to cure osteodegeneration by improving tissue regeneration
8.7 Prevent infections of bones
8.8 Effect of nanodrugs on immunity and bone implants
8.9 Cytotoxicity of using nanoparticles to bones
8.10 Conclusion
References
Chapter 9 Nanotechnology based gene delivery strategies towards disease therapy; advances and applications
9.1 Introduction
9.2 Methods of cancer treatment
9.3 Gene therapy
9.4 Nanogene delivery systems
9.5 Use of nanoparticle-based gene delivery in gynecological cancer
9.6 Nanoparticle-based gene delivery in renal diseases
9.7 Nanoparticle-based gene delivery in bone diseases
9.8 Nanoparticle-based gene delivery in the generation of transgenic plants
9.9 Conclusion and future prospects
Acknowledgement
References
Chapter 10 Nanonutrition- and nanoparticle-based ultraviolet rays protection of skin
10.1 Introduction
10.2 Ultraviolet radiation (UVR)
10.3 Human skin – a natural particle barrier
10.4 Sunscreen formulation
10.5 Organic UV filters
10.6 Inorganic UV filters
10.7 Lipid- and surfactant-based nanoparticles for broadband UV protection
10.8 New avenues in UV protection
10.9 Biological and environmental impacts of sunscreen ingredients
10.10 Conclusions
10.11 Future outlooks
References
Chapter 11 Drug and gene delivery by nanocarriers: Drug delivery process, in brief, using different oxides such as zinc, iron, calcium, polymeric, peptides, and in-vitro drug delivery process by silicon oxide (SiOx) and titanium dioxide (TiO2) nanodots (NDs)
11.1 Introduction
11.2 Glancing angel deposition technique (GLAD)
11.3 Conclusion
Uncited references
Reference
Chapter 12 Uncovering the limitation of nanodrug delivery system: Backdrop to the game changer
12.1 Introduction
12.2 Mechanism of the conventional method of treatment and concept of nanodrugs
12.3 The mechanism of nanodrug delivery
12.4 Cancer and need for nanodrug (present status)
12.5 NPs role cancer therapy
12.6 Challenges in the uptake of the nanodrug
12.7 Conclusion
Acknowledgments
References
Chapter 13 Preclinical, clinical, and patented nanodrug delivery systems
13.1 Background
13.2 Stages of drug development
13.3 Nanomaterials for DDS
13.4 Patented nanodrug delivery systems
13.5 Approved nano-based drug delivery systems
13.6 Conclusion
References
Chapter 14 Challenges and hazards associated with nanotechnology in agriculture
14.1 Introduction
14.2 Application of NPs in agriculture
14.3 Nanofertilizers
14.4 Nanopesticides
14.5 Using nano weed killer and insecticide in agriculture field
14.6 Future challenges
14.7 Conclusion
References
Chapter 15 Nanotechnology-based cancer drug delivery
15.1 Introduction
15.2 Nanocarriers used in drug delivery system
15.3 Nanoparticles
15.4 Quantum dots
15.5 Carbon nanotubes
15.6 Liposomes
15.7 Polymeric micelles
15.8 Dendrimers
15.9 Nanowires and nanocantilever
15.10 Conclusion
References
Chapter 16 Regulatory aspects: Toxicity and safety
16.1 Introduction
16.2 Clinical and toxicological aspects
16.3 Environmental toxicity
16.4 Methodological concerns for evaluating the safety of nanomedicines
16.5 Regulatory aspects
16.6 Future research needs
16.7 Conclusion
References
Chapter 17 Nanoparticles-based drug delivery to cure osteodegeneration by improving tissue regeneration
17.1 Introduction
17.2 Nanoparticles and its role in osteoporosis
17.3 Conclusion
References
Chapter 18 Applications of metal oxide nanoparticles in cancer therapy
18.1 Introduction
18.2 Metal oxide nanoparticle synthesis
18.3 Application of metal oxides in different types of cancer
18.4 Conclusion
References
Chapter 19 Recent approaches of nanodrug delivery and toxicity to untargeted organs
19.1 Introduction
19.2 Routes of nanodrug delivery
19.3 Biodistribution and pharmacokinetics of targeted therapeutics
19.4 Biodistribution
19.5 Cytotoxicity of nanoparticles
19.6 Future of the drug delivery systems
19.7 Conclusion
References
Chapter 20 Nanomaterials in tissue engineering: Applications and challenges
20.1 Introduction
20.2 Applications of different nanomaterials in the field of tissue engineering
20.3 Application of metallic nanoparticles in tissue engineering
20.4 Conductive polymers
20.5 Carbon nanotubes
20.6 Graphene
20.7 Hydrogels
20.8 Bioceramics
20.9 Different doped elements in biomaterial used for tissue engineering
20.10 Challenges and future perspectives
References
Chapter 21 Nanocarriers: A boon to the drug delivery systems
21.1 Introduction
21.2 Type/classes of nanocarriers
21.3 Synthesis methods for nanocarriers
21.4 Conclusion
References
Chapter 22 Nanomaterials in biomedicine: Synthesis and applications
22.1 Introduction
22.2 Conclusion
References
Chapter 23 Polymeric and metal nanostructures for bone regeneration and osteomyelitis treatment
23.1 Introduction
23.2 Bone regeneration and osteomyelitis treatment
23.2.1 Potential therapeutic agents
23.3 Bone cement structures and material
23.4 Nanostructures for drug release
23.5 Metal antimicrobial bone cements for the therapeutic treatment of osteomyelitis
23.6 Final remarks and future perspectives
Acknowledgments and funding
References
Index

Anupam Das Talukdar

Dr Anupam Das Talukdar, MSc PhD is an Assistant Professor at the Department of Life Science and Bioinformatics at Assam University, Silchar, India and have 12 years of teaching experience in the area of Phytochemistry He is an Editorial Board member and reviewer for the journal, Phytochemical Analysis. His research focuses on medicinal plants, and bioactive compounds for drug delivery and computer aided drug designing.. Dr Talukdar has edited 4 books and written 24 book chapters on the topic of natural products for medicinal purposes.He has published more than 80 articles in national and international peer reviewed journals covering medicinal plants of North Eastern part of India, bioactivity of phytochemicals , antimicrobial , anticancancer activity and insilico drug designing.Dr.Talukdar has supervised 12 PhD scholar in the area of phytochemistry and CADD and have 4 ongoing research projects funded by different Indian agencies like DBT,UGC and SERB.

Affiliations and expertise

Assistant Professor,Department of Life Science and Bioinformatics, Assam University, Silchar, India

Satyajit Dey Sarker

Prof Satyajit Sarker, the Editor-in-Chief of Phytochemical Analysis, and the former President of the Phytochemical Society of Europe (2018-20), is the Director of School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University. He has recently been awarded with an Honorary Professorship at the University of East Anglia (2020-24). He obtained BPharm (Hons) and MPharm degrees from Dhaka University, and completed his PhD in Phytochemistry from Strathclyde University, Glasgow, UK. His research focuses on anticancer, anti-inflammatory, antimalarial, antimicrobial, chemopreventive and wound-healing properties of phytochemicals. Prof Sarker is in the Editorial Board of >35 international journals.

Affiliations and expertise

Director, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK

Jayanta Kumar Patra

Dr Jayanta Kumar Patra, MSc, PhD, PDF, is an Associate Professor at Dongguk University, Republic of Korea. He has around 14 years of research and teaching experience in the fields of pharmacology and nano-biotechnology. His current research focuses on nanoparticle synthesis by green technology methods and associated biomedical applications: green synthesis of silver, gold, iron, calcium, phosphorous nanoparticles using food waste, agricultural waste and plant materials and evaluation of their antibacterial, antioxidant and cytotoxicity potential. He also focuses on the antibacterial synergistic potential of nanoparticles and conjugation with different antibiotics, drugs etc. along with ethno-medicinal potential of plants. Dr Patra has published >150 articles in various national and international peer-reviewed journals, including Materials Science and Engineering C, Nanomedicine: Nanotechnology, Biology, and Medicine, International Journal of nanomedicine and Journal of Nanobiotechnology and around 35 book chapters. He is editor of 16 books covering nanotechnology in pharmacology, biomedicine and food sciences, including titles published with Apple Academic Press, CRC Press and Springer. He is currently also an editorial board member of >10 international journals, including BMC Complementary and Alternative Medicine, Frontiers in Nanotechnology, Frontiers in Cellular and Infection Microbiology, and Frontiers in Microbiology.

Affiliations and expertise

Associate Professor, Research Institute of Integrative Life Sciences, Dongguk University, South Korea