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Advances in Molecular Pathology
- 1st Edition, Volume 5-1 - November 1, 2022
- Editor: Gregory J. Tsongalis
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 4 0 3 9 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 4 0 4 0 - 5
Advances in Molecular Pathology reviews the year’s most important findings and updates within the field in order to provide molecular pathologists with the current clinical… Read more
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Request a sales quoteAdvances in Molecular Pathology reviews the year’s most important findings and updates within the field in order to provide molecular pathologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Gregory Tsongalis, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in molecular pathology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care.
Provides in-depth, clinical reviews in molecular pathology, providing actionable insights for clinical practice.
Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
Pathology
- Cover image
- Title page
- Table of Contents
- Copyright
- Editorial Board
- Contributors
- Editorial
- Preface
- Genetics
- Polygenic Risk Scores in Clinical Care
- Key points
- Introduction
- Generation, validation, and evaluation of polygenic risk scores
- Translating polygenic risk scores from research into clinical care
- Reporting risk from polygenic risk scores
- Considerations in communicating polygenic risk scores
- Polygenic risk scores today and in the future
- Clinics care points
- Disclosure
- Hereditary Cancer and Cancer Predisposition Syndromes
- Key points
- Introduction
- Cancer predisposition syndromes in children and adults
- Genetic syndromes with cancer predisposition as part of the phenotype
- Germline mutation contributions to non-syndromic cancer predisposition
- Polygenic hereditary contribution to cancer
- Genomic testing in hereditary cancer
- Concluding remarks
- Disclosure
- Hematopathology
- Expanding the Molecular Landscape of Cutaneous T-Cell Lymphoma
- Key points
- Introduction
- Classical subtypes of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome
- CD30-positive T-cell lymphoproliferative disorders
- Uncommon subtypes of cutaneous T-cell lymphoma
- Discussion
- Summary
- Clinics care points
- High-Grade B-cell Lymphomas
- Key points
- Introduction
- Discussion and future directions
- Clinics care points
- Molecular Advances in Nodal Peripheral T-Cell Lymphoma
- Key points
- Introduction
- Peripheral T-cell lymphoma—not otherwise specified
- Nodal lymphoma of T follicular helper cell origin
- Angioimmunoblastic T-cell lymphoma
- Follicular T-cell lymphoma
- Nodal peripheral T-cell lymphoma with a T follicular helper phenotype
- Anaplastic large cell lymphoma
- Multiple Myeloma
- Key points
- Multiple myeloma overview
- Plasma cell biology
- Cytogenetics
- Genomics
- Gene expression profiles (transcriptomics)
- Single-cell analysis
- (Macro) spatial heterogeneity
- Single-cell spatial genomics
- Other therapies
- Minimal residual disease
- Summary
- Clinics care points
- Infectious Disease
- Prevalence and Clinical Disease Severity of Respiratory Coinfections During the Coronavirus Disease 2019 Pandemic
- Key points
- Introduction
- Respiratory viral coinfections
- Bacterial coinfection in the setting of respiratory viral illness
- Disclosure
- Applications of Long-Read Sequencing Technology in Clinical Genomics
- Key points
- Introduction
- Long-read technology in genetics and genomics research
- Structural variants detection and cancer
- Structural variations and genetic disorders
- Transposable elements
- Haplotype resolution
- Identifying pseudogenes
- Tandem repeat expansion diseases
- Applications of long-read technology in neurogenomics
- Fragile X syndrome
- Spinocerebellar ataxias
- Huntington’s disease
- Long-read technology in infectious disease and research
- Long-read sequencing in metagenomics application
- Challenges and issues in long-read technology
- Data analytics
- Summary and future prospects
- Clinics care points
- Pharmacogenomics
- SLCO1B1 Pharmacogenetics in Pediatrics
- Key points
- Introduction
- Summary
- Implementation of a Clinical Pharmacogenomics Service in a Large Freestanding Pediatric Health System
- Key points
- Introduction
- History of Children’s Minnesota pharmacogenomics program
- Pharmacogenomics clinic workflow and patient care process
- Provider perspective of pharmacogenomics implementation from a pediatric hematology/oncology physician
- Pharmacogenomics research
- Developing a pharmacogenomics genotyping assay
- Summary
- Supplementary data
- Artificial Intelligence/Machine Learning and Mechanistic Modeling Approaches as Translational Tools to Advance Personalized Medicine Decisions
- Key points
- Introduction
- Artificial intelligence-based and machine learning-based approaches for personalized cardiovascular medicine
- Artificial intelligence-based and machine learning-based approaches for personalized cancer medicine
- Tackling molecular pathology heterogeneity with physiologically based pharmacokinetic models to advance translational research efforts and personalized medicine decisions
- Machine learning-based translational pharmacogenomics tools to advance personalized medicine
- New drug development and drug repurposing through the application of artificial intelligence and machine learning approaches in drug development
- Summary
- Clinics care points
- Solid tumors
- Advances in Cell-Free DNA
- Key points
- Significance
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 5-1
- Published: November 1, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323940399
- eBook ISBN: 9780323940405
GT
Gregory J. Tsongalis
Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.
Affiliations and expertise
Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth, Hitchcock Medical Center and Dartmouth Cancer Center, Lebanon, NH, United States and the Geisel School of Medicine at Dartmouth, Hanover, NH, USA