Advances in Molecular Pathology, 2019
- 1st Edition, Volume 2-1 - October 28, 2019
- Latest edition
- Editor: Gregory J. Tsongalis
- Language: English
This issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology.… Read more
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This issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology. Publishing on an annual basis, the volume will be divided into 7 sections: Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid tumors, and Identity/HLA. Led by Dr. Gregory Tsongalis of Dartmouth University, a team of experienced pathologists from institutions across the country oversee annual topic and expert author selection.
Advances in Molecular Pathology Volume 2.1 Table of Contents
Preface
Molecular Pathology: Unraveling the Underlying Complexities of Human Disease
By Gregory J. Tsongalis
Genetics
The Evolution of Constitutional Sequence Variant Interpretation
By Jessica Mester and Tina Pesaran
The Future of Clinical Diagnosis: Moving Functional Genomics Approaches to the Bedside
By Rini Pauly and Charles E. Schwartz
Genomic Data in the Electronic Health Record
By Nephi A. Walton, Darren K. Johnson, Thomas N. Person, and Srikar Chamala
Hematopathology
Molecular Genetics in Myelodysplasia Outcomes Prognostication
By Lucas H. Rifkin and Eric Y. Loo
Assessing Measurable Residual Disease in Acute Myeloid Leukemia
By Daniel L. Duncan, Joshua F. Zeidner, and Nathan D. Montgomery
Philadelphia-Like Lymphoblastic Leukemia: Approach to Testing in Clinical Laboratories for Diagnosis, Prognosis, and Therapeutic Risk Assessment
By Michelle Afkhami
Myeloid Gene Panel Testing with Correlation to Updated Clinical Practice Guidelines
By Laura N. Toth and Daniel Babu
Infectious Disease
Impact of Molecular Diagnostics on Antimicrobial Stewardship
By Sheila M. Johnson, Mackenzie E. Collins, and Melissa B. Miller
Application of Next-Generation Sequencing in Public Health Epidemiology and Outbreak Investigation
By Anthony Tran and Marie-Claire Rowlinson
Next-Generation Sequencing Approaches to Predicting Antimicrobial Susceptibility Testing Results
By Rebecca Yee and Patricia J. Simner
Pharmacogenomics
Artificial Intelligence and Pharmacogenomics: A Timely Synergy for Individualizing Medicine
By Ravishankar K. Iyer, Arjun P. Athreya, Liewei Wang, and Richard M. Weinshilboum
The Evolution of DNA Sequencing in Pharmacogenomics
By Steven E. Scherer
Consumer-initiated Genetic Testing and Pharmacogenomics
By Ann M. Moyer and Linnea M. Baudhuin
Informatics
Machine Learning in Biology and Medicine
By Javad Noorbakhsh, Harshpreet Chandok, R. Krishna Murthy Karuturi, and Joshy George
Solid Tumors
Clinical Use of Cell-Free DNA in Tumor Diagnostics
By Tejus A. Bale and Maria E. Arcila
Practical Concepts, Current Challenges, and Technological Advances in Clinical Next- Generation Sequencing Assays for Solid Tumors
By Mir B. Alikhan, Mustafa Al-Kawaaz, Karen Kaul, and Linda Sabatini
Evidence Builds for Tumor Mutation Burden as an Immunotherapy Biomarker
By Andrea Ferreira-Gonzalez
Identity/HLA
Human Leukocyte Antigen Typing Using High- Throughput DNA and RNA Sequencing and Application for Cell Line Identification
By Sebastian Boegel and John C. Castle
Expanding the Connectivity Map Concept as the Functional Look-Up Table for Systems Biology
By Bernard Kok Bang Lee, Sok Ching Cheong, and Aik Choon Tan
- Edition: 1
- Latest edition
- Volume: 2-1
- Published: October 28, 2019
- Language: English
GT
Gregory J. Tsongalis
Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.
Affiliations and expertise
Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth, Hitchcock Medical Center and Dartmouth Cancer Center, Lebanon, NH, United States and the Geisel School of Medicine at Dartmouth, Hanover, NH, USA