Advances in Medicinal Chemistry
- 1st Edition, Volume 3 - January 4, 1996
- Latest edition
- Editors: B.E. Maryanoff, C.A. Maryanoff
- Language: English
Volume 3 of Advances in Medicinal Chemistry is comprised of four chapters on diverse aspects of medicinal chemistry. Chapter 1 presents an account of a research program which… Read more
Description
Description
Volume 3 of Advances in Medicinal Chemistry is comprised of four chapters on diverse aspects of medicinal chemistry. Chapter 1 presents an account of a research program which was started to discover a novel antipsychotic agent with minimal side effects for the treatment, principally, of schizophrenia. Chapter 2 relates an account on the discovery of novel antithrombotic drugs based on the RGD motif through a rational design approach. Chapter 3 presents the medicinal chemistry and preclinical development surrounding sertraline, a very important serotonin reuptake drug for the treatment of endogenous depression. Finally, Chapter 4 gives a summary of a series of boronic acid-based immunosuppressants that operate via inhibition of dipeptidypeptidase IV.
Table of contents
Table of contents
List of Contributors.
Preface (B.E. Maryanoff and C.A. Maryanoff).
1. Novel Antipsychotics with Unique D2/5-HT1A Affinity and Minimal Extrapyramidal Side Effect Liability (A.B. Reitz and M.K. Scott).
2. Antiplatelet and Antithrombotic Agents: from Viper Venom Proteins, to Peptides and Peptidomimetics, to Small Organic Molecules (P.L. Barker and R.R. Webb, II).
3. Discovery and Preclinical Development of the Serotonin Reuptake Inhibitor Sertraline (W.M. Welch).
4. Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: A New Class of Immunosuppressive Agents (R.J. Snow and W.W. Bachovchin).
Index.
Preface (B.E. Maryanoff and C.A. Maryanoff).
1. Novel Antipsychotics with Unique D2/5-HT1A Affinity and Minimal Extrapyramidal Side Effect Liability (A.B. Reitz and M.K. Scott).
2. Antiplatelet and Antithrombotic Agents: from Viper Venom Proteins, to Peptides and Peptidomimetics, to Small Organic Molecules (P.L. Barker and R.R. Webb, II).
3. Discovery and Preclinical Development of the Serotonin Reuptake Inhibitor Sertraline (W.M. Welch).
4. Boronic Acid Inhibitors of Dipeptidyl Peptidase IV: A New Class of Immunosuppressive Agents (R.J. Snow and W.W. Bachovchin).
Index.
Product details
Product details
- Edition: 1
- Latest edition
- Volume: 3
- Published: January 4, 1996
- Language: English
About the editors
About the editors
BM
B.E. Maryanoff
Affiliations and expertise
Medicinal Chemistry Department, R.W. Johnson Pharmaceutical Research Institute, Springhouse, Pennsylvania, USACM
C.A. Maryanoff
Affiliations and expertise
Chemical Development Department, R.W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USAView book on ScienceDirect
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