LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Advances in Intestinal Transplantation, Part II, An Issue of Gastroenterology Clinics of North America
- 1st Edition, Volume 53-3 - July 31, 2024
- Editor: Alan L Buchman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 4 1 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 4 2 - 4
In this issue of Gastroenterology Clinics, guest editor Dr. Alan L. Buchman brings his considerable expertise to the topic of Advances in Intestinal Transplantation, Part II. In th… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteIn this issue of Gastroenterology Clinics, guest editor Dr. Alan L. Buchman brings his considerable expertise to the topic of Advances in Intestinal Transplantation, Part II. In this second of two issues devoted to the comprehensive coverage of this topic, top experts discuss the complexities of intestinal failure (IF) and provide a better understanding of medical and surgical management. Coverage also includes assessment of when patients should be referred to select centers of expertise where both medical and surgical (nontransplant and transplant) modalities are available.
- Contains 12 relevant, practice-oriented topics including innate and cellular immune responses in intestinal transplantation: new discoveries: altering the microbiome and implications for host metabolomics; vaccines and vaccine response: other maintenance care in the small bowel transplant patient; living donor intestinal transplantation; the stem cell niche in short bowel syndrome; and more.
- Provides in-depth clinical reviews on advances in intestinal transplantation, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Gastroenterologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- B-Cell Induction Therapies in Intestinal Transplantation
- Key points
- Background
- Nature of the problem
- Clinical evidence
- Therapeutic options
- Summary
- Clinics care points
- Innate and Adaptive Immune Responses in Intestinal Transplant Rejection: Through the Lens of Inflammatory Bowel and Intestinal Graft-Versus-Host Diseases
- Key points
- Introduction
- Innate immunity in intestinal transplantation
- Loss of paneth cells may contribute to worsening of intestinal transplant rejection
- An overview of the mononuclear phagocyte system
- M1 macrophages orchestrate allogeneic dysregulation between host and graft
- M2 macrophages are effectors of chronic rejection
- Regulatory macrophages maintain immunologic homeostasis that is critical to graft survival
- Natural killer cells are capable of inducing both tolerance and tissue destruction
- Overview of innate lymphoid cells
- Type 1 innate lymphoid cells ILCS are effectors of proinflammatory immune dysregulation
- Type 2 innate lymphoid cells do not appear to play a major role in the innate immunity of the intestine
- Type 3 innate lymphoid cells population maintains immune homeostasis and tissue tolerance
- ILC1:ILC3 ratio predicts outcome in inflammatory bowel disease and intestinal transplantation
- Type 3 innate lymphoid cells can trans-differentiate into type 1 innate lymphoid cells
- High levels of IL-22 secreted by ILC3S in intestinal allograft biopsies IS associated with graft tolerance and survival
- Adaptive immunity in intestinal transplantation
- T cell activation: a new player emerges—the inverted direct pathway
- Type 1 and type 2 T helper cells are the foundations of intestinal inflammation
- Intestinal graft rejection is driven by type 17 T helper cells
- Regulatory T cells assume a proinflammatory TH1/TH17-like phenotype in ITX rejection, leading to loss of their immunosuppressive function
- TH17/TREG paradigm: imbalance of relative TH17 and Treg cell populations and T cell plasticity potentially exacerbates intestinal transplantation rejection
- Unconventional T cells in the GI tract may also contribute to intestinal transplant rejection
- Summary
- Clinics care points
- Metabolomic Applications in Gut Microbiota-Host Interactions in Human Diseases
- Key points
- Introduction
- Background
- Approach
- Integrating metabolomics in gut microbiome-disease interactions
- Gut bacterial and metabolic alterations in gastrointestinal diseases
- Gut bacterial and metabolic alterations in systemic diseases
- Discussion
- Metabolic Regulation of Microbiota and Tissue Response
- Key points
- Introduction
- Regulation of nutrition
- Regulation of barrier function and immunity
- Concluding remarks
- Funding
- Chimerism-Mediated Tolerance in Intestinal Transplantation
- Key points
- Background
- Discussion
- Summary
- Clinics care points
- Vaccines and Vaccine Response in the Small Bowel Transplant Patient
- Key points
- Introduction
- Clinics care points
- Living Donor Intestinal Transplantation
- Key points
- Introduction
- History
- Donor selection and recipient evaluation
- Surgical technique and postoperative care
- Immunosuppression
- Outcomes of living donor intestinal transplantation
- Pediatric intestinal transplantation
- Summary
- Clinics care points
- Intestinal Re-Transplantation
- Key points
- Introduction
- History
- Indication for intestinal re-transplantation
- Immunosuppression
- The liver effect
- The role of the spleen
- Operative considerations
- Outcomes after intestinal re-transplantation
- Summary
- Clinics care points
- Bioengineering of Intestinal Grafts
- Key points
- Main
- Discussion
- Summary
- Clinics care points
- The Stem Cell Niche in Short Bowel Syndrome
- Key points
- Introduction and background
- Summary
- A Novel Organoid-Based Strategy Using Hybrid Colon Interposition for Short Bowel Syndrome: A Mini Review of In Vivo Models and Possible Human Candidates
- Key points
- Introduction
- In vivo animal models for intestinal organoid transplantation
- Cases considered suitable for new surgical methods at centers treating with a high number of patients with SBS
- Clinics care points
- Update on Maintenance Immunosuppression in Intestinal Transplantation
- Key points
- Introduction
- Maintenance immunosuppression background
- Discussion
- Clinics care points
- Intestinal Transplantation in the Developing World
- Key points
- Introduction
- Definitions
- Current situation of intestinal transplantation in the world
- Intestinal transplantation in the Middle East and Asia
- Intestinal transplantation in Latin-America
- Discussion
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 53-3
- Published: July 31, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443131417
- eBook ISBN: 9780443131424
AB
Alan L Buchman
Affiliations and expertise
Professor of Clinical Surgery, Medical Director, Intestinal Rehabilitation and Transplant Center, The University of Illinois at Chicago/UI Health,