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Advances in Immunology
- 1st Edition, Volume 162 - June 11, 2024
- Editors: Frederick Alt, Kenneth Murphy
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 4 9 8 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 4 9 9 - 0
Advances in Immunology, Volume 162, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immuno… Read more
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Request a sales quoteAdvances in Immunology, Volume 162, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding and respected serial on the subject matter
- Focuses on recent advances in the field of immunology
Immunologists and infectious disease specialists, cell biologists and hematologists
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: The molecular mechanism of dsDNA sensing through the cGAS-STING pathway
- Abstract
- 1 Introduction
- 2 The mechanism of cGAS activation by dsDNA
- 3 The regulation of cGAS activity
- 4 The mechanism of STING activation by cGAMP
- 5 The recruitment and activation of TBK1 by STING
- 6 The recruitment and activation of IRF3 via STING
- 7 Future perspectives
- References
- Chapter Two: Crosstalk between CD8+ T cells and mesenchymal stromal cells in intestine homeostasis and immunity
- Abstract
- 1 Introduction
- 2 Classification and function of CD8+ T cells in intestine
- 3 Current understanding of intestinal mesenchymal stromal cell subsets
- 4 CD8+ T cell-intestinal mesenchymal stromal cell interaction
- 5 Methods to study the interaction of intestinal CD8+ T cell and stromal cells
- 6 Concluding remarks
- Declaration of Generative AI and AI-assisted technologies in the writing process
- References
- Chapter Three: The regulation of the apoptotic pore—An immunological tightrope walk
- Abstract
- 1 Introduction
- 2 Regulation of the apoptotic pore
- 3 Consequences of apoptotic pore formation
- 4 Concluding remarks
- Declaration of AI and AI-assisted technologies in the writing process
- References
- Chapter Four: Germinal center versus extrafollicular responses in systemic autoimmunity: Who turns the blade on self
- Abstract
- 1 Introduction
- 2 Assumptions that led to a pathogenic interpretation of spontaneous GCs
- 3 Evidence of GC-independent systemic autoimmunity
- 4 GCs as a gatekeeper of B cell tolerance
- 5 Extrafollicular B cell responses in autoimmunity
- 6 Concluding remarks
- References
- No. of pages: 198
- Language: English
- Edition: 1
- Volume: 162
- Published: June 11, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443294983
- eBook ISBN: 9780443294990
FA
Frederick Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Professor of Pediatrics and Professor of Genetics, Harvard Medical School, Boston, MA, USAKM
Kenneth Murphy
Kenneth M. Murphy works in Washington University School of Medecine, USA.
Affiliations and expertise
Washington University School of Medecine, USA