Advances in Immunology
- 1st Edition, Volume 159 - November 21, 2023
- Editors: Frederick W. Alt, Kenneth Murphy
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 3 2 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 3 3 - 0
Advances in Immunology, Volume 159, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immuno… Read more
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Request a sales quoteAdvances in Immunology, Volume 159, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology with chapters covering topics such as the cGAS-STING pathway.
- Presents current developments and comprehensive reviews in immunology
- Provides the latest in a longstanding and respected serial on the subject matter
- Focuses on recent advances in immunology
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Chapter One: Advances in structure-guided mechanisms impacting on the cGAS–STING innate immune pathway
- Abstract
- 1 Introduction
- 2 Sensor cGAS
- 3 Second messenger 2′3′-cGAMP
- 4 Adaptor STING
- 5 Future challenges
- References
- Chapter Two: The show and tell of cross-presentation
- Abstract
- 1 Introduction
- 2 Cross-presentation capacity of dendritic cell subsets
- 3 Cellular pathways mediating cross-presentation
- 4 Regulation of cross-presentation
- 5 Cross-presentation in disease context
- 6 Knowledge gaps in understanding cross-presentation
- References
- Chapter Three: MHC cross-dressing in antigen presentation
- Abstract
- Abbreviations
- 1 Impact of MHC cross-dressing on in vivo antigen presentation
- 2 Mechanisms of MHC cross-dressing
- 3 Cell types involved in MHC cross-dressing
- 4 Conclusions and future directions
- Acknowledgments
- References
- No. of pages: 198
- Language: English
- Edition: 1
- Volume: 159
- Published: November 21, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443193323
- eBook ISBN: 9780443193330
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Frederick W. Alt
Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.
Affiliations and expertise
Investigator and Director, Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USAKM
Kenneth Murphy
Kenneth M. Murphy works in Washington University School of Medecine, USA.
Affiliations and expertise
Washington University School of Medecine, USARead Advances in Immunology on ScienceDirect