Advances in Immunology

Chapter One: γδ T Cells and B Cells
W.K. Born, Y. Huang, R.L Reinhardt, H. Huang, D. Sun and R.L. O’Brien

• Abstract
• 1 Tripartite Adaptive Immune System
• 2 γδ T Cells
• 3 Interaction Between γδ T Cells and B Cells

Chapter Two: A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes
V.Y. Lim, S. Zehentmeier, C. Fistonich and J.P. Pereira

• Abstract
• 1 Introduction
• 2 HSC Niches
• 3 Hematopoietic Multipotent Progenitor Niches
• 4 Bone Marrow Niches Controlling Lymphoid Lineage Commitment
• 5 Transition From ProB to PreB to Immature B Cell
• 6 Egress From Bone Marrow
• 7 Transitional Differentiation in Periphery
• 8 Concluding Remarks
• Acknowledgments

Chapter Three: Tissue-Specific Diversity and Functions of Conventional Dendritic Cells
D. Pakalniškytė and B.U. Schraml

• Abstract
• 1 Dendritic Cell Development
• 2 cDCs in Lymphoid Organs
• 3 cDCs in Nonlymphoid Organs
• 4 Concluding Remarks
• Acknowledgments

Chapter Four: Regulation of Innate and Adaptive Immunity by TGFβ
iAbstract

• 1 Introduction
• 2 TGFβ and the Adaptive Immune System
• 3 TGFβ and the Innate Immune System
• 4 Concluding Remarks
• Acknowledgments

Chapter Five: Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem
L. Verkoczy

• Abstract
• 1 Overview of the Current State of HIV Vaccine Research
• 2 Characteristics of bnAbs Isolated During Infection and Their Env Targets: Clues for Vaccine Design
• 3 Current Gaps in HIV Vaccinology
• 4 Human Ig KI Models in Elucidating bnAb Tolerance Controls and Testing Ways to Overcome Them
• 5 bnAb KI Models for Testing New HIV Vaccine Strategies
• 6 Ig KI-Related Methodological Advances Relevant for Studying bnAb Development
• 7 Perspectives
• Acknowledgments