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Advances in Clinical Cytometry, An Issue of the Clinics in Laboratory Medicine
- 1st Edition, Volume 43-3 - July 24, 2023
- Editor: Christopher B. Hergott
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 8 2 8 4 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 8 2 8 5 - 3
In this issue of Clinics in Laboratory Medicine, guest editor Dr. Christopher Hergott brings his considerable expertise to the topic of Advances in Clinical Cytometry. Flow… Read more
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Request a sales quoteIn this issue of Clinics in Laboratory Medicine, guest editor Dr. Christopher Hergott brings his considerable expertise to the topic of Advances in Clinical Cytometry. Flow cytometry is an essential tool in biology, pathology, and medicine thanks to its combination with the advancements in computer sciences. In this issue, top experts inform readers on the various aspects of clinical cytometry and its applications in the field, as well as new technologies.
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Contains 11 practice-oriented topics including immunophenotypic profile of the healthy human bone marrow; advances in monitoring and prognostication for lymphoma by flow cytometry; clinical flow cytometry for Hodgkin’s lymphoma; clinical cytometry and translational drug development; and more.
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Provides in-depth clinical reviews of advances in clinical cytometry, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Laboratory medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Immunophenotypic Profile of Healthy Human Bone Marrow
- Key points
- Introduction
- Hematopoietic stem cells and progenitors
- Erythroid and megakaryocytic lineages
- Granulocytic and monocytic lineages
- Lymphoid lineages
- Correlation of flow cytometry with molecular phenotypes
- Summary
- Clinics care points
- Disclosure
- Funding
- How to Design and Validate a Clinical Flow Cytometry Assay
- Key points
- Introduction
- History
- Definitions
- Discussion
- Clinical care points: pearls and pitfalls
- Clinics care points
- Advances in Monitoring and Prognostication for Lymphoma by Flow Cytometry
- Key points
- Introduction
- Clinics care points
- Disclosure
- Flow Cytometry in Diagnosis, Prognostication, and Monitoring of Multiple Myeloma and Related Disorders
- Key points
- Overview of plasma cell neoplasms and other disorders with clonal plasma cell expansions
- Role of flow cytometry in the diagnostic evaluation of plasma cell expansions
- Role of flow cytometry in the prognostication of plasma cell neoplasms at diagnosis
- Role of measurable residual disease in the assessment of treatment response in multiple myeloma
- Quantitative aspects of measurable residual disease assessment
- Sample collection
- Flow cytometric panel design
- Targeted therapy
- Funding
- Clinics care point
- Advances in Acute Myeloid Leukemia Classification, Prognostication and Monitoring by Flow Cytometry
- Key points
- Introduction
- Advances in acute myeloid leukemia phenotype/genotype correlation
- Advances in measurable residual disease monitoring for acute myeloid leukemia
- Challenges and open questions
- Clinics care points
- Disclosure
- Funding
- Advances in Flow Cytometry for Mixed Phenotype and Ambiguous Leukemias
- Key points
- Introduction
- History
- Discussion
- Flow cytometric evaluation of newly described acute leukemias of ambiguous lineage entities
- Summary
- Clinics care points
- Disclosure
- Clinical Flow Cytometry Analysis in the Setting of Chronic Myeloid Neoplasms and Clonal Hematopoiesis
- Key points
- Introduction
- Evaluation of bone marrow cellular compartments using flow cytometry analysis
- Flow cytometry-based scoring systems in chronic myeloid neoplasms
- The utility of flow cytometry analysis in the evaluation of chronic myeloid neoplasms
- The utility of flow cytometry analysis in evaluating clonal hematopoiesis without overt morphologic dysplasia
- Summary
- Clinics care points
- Key/essential headings
- Conflict of interest Disclosure
- A Review of the Flow Cytometric Findings in Classic Hodgkin Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma and T Cell/Histiocyte-Rich Large B Cell Lymphoma
- Key points
- Introduction
- Conclusions regarding unique antigens used in characterization of CHL, NLPHL, and THRLBCL
- Summary
- Clinics care points
- Disclosure
- Clinical Cytometry for Platelets and Platelet Disorders
- Key points
- Background
- Discussion
- Current clinical applications
- Emerging applications and future challenges
- Clinics care points
- Disclosures
- Utility of Flow Cytometry Analysis in the Detection of Nonhematologic Neoplasms: An Overview
- Key points
- Introduction and background
- Discussion and Summary
- Clinics care points
- Disclosure
- Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders
- Key points
- Flow cytometry: novel methods drive the discovery of novel subsets
- Conceptual evolution in our understanding of primary immunodeficiencies
- T-bet+ B cells
- Summary
- Clinics care points
- Artificial Intelligence for Clinical Flow Cytometry
- Key points
- Introduction
- History
- Definitions
- Background
- Discussion
- Summary
- Clinics care points
- Disclosure
- Advances in Clinical Mass Cytometry
- Key points
- Introduction
- Cytometry by time of flight-based functional assays
- Cytometry by time of flight in combination with multi-omics
- Clinical applications of cytometry by time of flight
- Future directions
- Summary
- Clinics care points
- Funding
- Statements and declarations
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 43-3
- Published: July 24, 2023
- Imprint: Elsevier
- Hardback ISBN: 9780443182846
- eBook ISBN: 9780443182853
CH
Christopher B. Hergott
Affiliations and expertise
Department of Pathology, Brigham and Women's Hospital