Advances in Clinical Chemistry
- 1st Edition, Volume 116 - October 13, 2023
- Editor: Gregory S. Makowski
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 9 2 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 9 3 - 7
Advances in Clinical Chemistry, Volume 116, the latest release in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scient… Read more
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Request a sales quote- Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science
- Authored by world renowned clinical laboratory scientists, physicians and research scientists
- Presents the international benchmark for novel analytical approaches in the clinical laboratory
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Advances in fentanyl testing
- Abstract
- 1 Introduction
- 2 Fentanyl metabolism and pharmacokinetics
- 3 Testing matrix
- 4 Immunoassays for fentanyl
- 5 Mass spectrometry
- Further reading
- References
- Chapter Two: Phosphorylated tau in Alzheimer’s disease
- Abstract
- Abbreviations
- 1 Introduction
- 2 Method
- 3 Results
- 4 Discussion
- 5 Conclusion
- Conflict of interest
- References
- Chapter Three: Predictive risk markers in alcoholism
- Abstract
- Abbreviations
- 1 Introduction
- 2 Ethanol and its metabolites for assessing problem drinking
- 3 Carbohydrate-deficient transferrin (CDT)
- 4 Liver enzymes in AUD
- 5 Acute phase and oxidative stress related responses induced by heavy drinking
- 6 Markers of inflammatory status in AUD
- 7 Ethanol-induced blood cell deviations
- 8 Alcohol and lipid status
- 9 Alcohol consumption in combinations with other lifestyle risk factors
- 10 Impact of sex and age
- 11 Predictors of fetal alcohol effects
- 12 Assessment of genetic predisposition
- 13 What can we expect from machine learning approaches
- 14 Assessment of tissue toxicity in AUD
- 15 Summary and future perspectives
- Acknowledgments
- References
- Chapter Four: Biomarkers in psychiatric disorders
- Abstract
- 1 Introduction
- 2 The search for biomarkers of psychiatric disorders
- 3 Strategies for biomarker discovery
- 4 Precision medicine biomarkers in psychiatric disorders
- 5 Concluding remarks
- Acknowledgments
- References
- Chapter Five: Uric acid en route to gout
- Abstract
- 1 Introduction
- 2 Uric acid (UA) chemistry
- 3 UA analysis
- 4 Physiologic roles of UA
- 5 Hypouricemia
- 6 Hyperuricemia (HU): Symptomatic and asymptomatic
- 7 Gout
- 8 HU does not necessarily induce gout
- 9 Therapies for HU and gout
- 10 Future perspectives
- 11 Conclusions
- Conflicts of interest
- References
- Further reading
- Chapter Six: Measurement uncertainty
- Abstract
- 1 Evolution of measurement uncertainty idea
- 2 Terminology
- 3 Quality of measurement result
- 4 Approaches of estimation measurement uncertainty
- 5 Strategies to estimate measurement uncertainty
- 6 Practical application in clinical practice
- 7 Conclusions and future considerations
- Acknowledgment
- References
- Further reading
- Index
- No. of pages: 342
- Language: English
- Edition: 1
- Volume: 116
- Published: October 13, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443192920
- eBook ISBN: 9780443192937
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board-certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President Clinical Laboratory Services Hartford HealthCare in Connecticut.