Advances in Biomedical Engineering, Volume 5, is a collection of papers that deals with application of the principles and practices of engineering to basic and applied biomedical research, development, and the delivery of health care. The papers also describe breakthroughs in health improvements, as well as basic research that have been accomplished through clinical applications. One paper examines engineering principles and practices that can be applied in developing therapeutic systems by a controlled delivery system in drug dosage. Another paper examines the physiological and materials variables that can influence the stability of a biomaterial interface. The interface, in particular, concerns living and nonliving substances to create a functional and efficient replacement of a body part. For space use, NASA has developed bioinstrumentation systems that are reliable, safe, small, and subject-acceptable. Another paper examines the problems associated with the application of systems analysis to societies in the real world. The collection is suitable for biochemists, pharmacologists, bio-engineers, and investigators whose works involve biomedical engineering and drug therapeutics.