Advanced Nanomaterials for Point of Care Diagnosis and Therapy

1st Edition - March 11, 2022
Editors: Sushma Dave, Jayashankar Das, Sougata Ghosh
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 7 2 5 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 0 6 6 - 9

Advanced Nanomaterials for Point of Care Diagnosis and Therapy provides an overview of technological and emerging novel trends in how point-of-care diagnostic devices are designed,… Read more

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Advanced Nanomaterials for Point of Care Diagnosis and Therapy provides an overview of technological and emerging novel trends in how point-of-care diagnostic devices are designed, miniaturized built, and delivered at different healthcare set ups. It describes the significant technological advances in fundamental diagnostic components and recent advances in fully integrated devices designed for specific clinical use. The book covers state-of-the-art fabrication of advances materials with broad spectrum therapeutic applications. It includes drug delivery, biosensing, bioimaging and targeting, and outlines the development of inexpensive, effective and portable in vitro diagnostics tools for any purpose that can be used onsite.

Sections also discuss drug delivery, biosensing, bioimaging and targeting and various metal, metal oxide and non-metal-based nanomaterials that are developed, surface modified, and are being explored for diagnosis, targeting, drug delivery, drug release and imaging. The book concludes with current needs and future challenges in the field.

Cover Image
Title Page
Copyright
Table of Contents
Contributors
Chapter 1 Nanomaterials-based biosensors
Abstract
1.1 Introduction
1.2 Classification based on detection techniques
1.3 Nanozymes
1.4 Conclusion
References
Chapter 2 Emerging technology for point-of-care diagnostics: Recent developments
Abstract
2.1 Introduction
2.2 Power systems
2.3 Technologies involved
2.4 Monitoring health parameters
2.5 Biomarkers for disease diagnosis
References
Chapter 3 Quantum dots enabled point-of-care diagnostics: A new dimension to the nanodiagnosis
Abstract
3.1 Introduction
3.2 Characteristics of quantum dots-based point-of-care testing device
3.3 Nanobiosensors for point-of-care diagnostics
References
Chapter 4 Nanomaterials-based disposable electrochemical devices for point-of-care diagnosis
Abstract
4.1 Introduction
4.2 Paper-based disposable sensors for point-of-care testing
4.3 Screen-printed disposable sensors for point-of-care analysis
4.4 Ink-jet printed disposable sensors
4.5 Laser-scribed graphene based disposable sensors
4.6 Recent advances and future perspectives
4.7 Summary
Acknowledgement
References
Chapter 5 Fabrication of nanomaterials for biomedical imaging
Abstract
5.1 Introduction
5.2 Bioimaging modalities
5.3 Fabrication of nanomaterials for bioimaging
5.4 Nanoparticle design considerations: Core and surface fabrication
5.5 Fabrication techniques of nanoparticles
5.6 Conclusions
Acknowledgement
References
Chapter 6 Surface modification with nanomaterials for electrochemical biosensing application
Abstract
6.1 Introduction
6.2 Essential requirement and role of nanomaterials in ideal biosensors development
6.3 Fabrication of electrochemical biosensors using nanomaterials
6.4 Conclusions, future prospects, and challenges
Acknowledgements
References
Chapter 7 Nanomaterials for sensors: Synthesis and applications
Abstract
7.1 Introduction of nanomaterials
7.2 Classification of nanomaterials
7.3 Synthesis of nanomaterials
7.4 Properties of nanomaterials
7.5 Characterization of nanoparticles
7.6 Nanomaterials application in sensing
7.7 Conclusion and future aspects
References
Chapter 8 A comprehensive study toward the treatment of inflammatory diseases through nanoparticles
Abstract
8.1 Introduction
8.2 Computational details
8.3 Results and discussion
8.4 Conclusions
References
Chapter 9 Recent advances of nanomaterial sensor for point-of care diagnostics applications and research
Abstract
9.1 Introduction
9.2 Working principles of nanomaterial sensors
9.3 Types of nanosensors
9.4 Dimension of nanomaterials sensor
9.5 Point-of-care applications
9.6 Future perspectives and research
9.7 Conclusion
Conflicts of interest
Acknowledgments
References
Chapter 10 Hybrid organic or inorganic nanomaterials for healthcare diagnostics
Abstract
10.1 Introduction
10.2 Classification of organic and inorganic materials
10.3 Different types of inorganic and organic nanomaterial in treatment
10.4 Applications in healthcare
10.5 Prevailing scenario of nanomaterials in diagnostics and therapeutics
10.6 Future perspectives and conclusions
References
Chapter 11 Carbon nanomaterials: Application as sensors for diagnostics
Abstract
11.1 Introduction
11.2 Carbon-based nanomaterials
11.3 Biosensor applications
11.4 Conclusion
References
Chapter 12 Modification of screen printed biosensors using nanomaterials
Abstract
12.1 Introduction
12.2 Classification of nanomaterials for biosensors
12.3 Modification of screen printed electrodes using nanomaterials
12.4 Advantages of modification
12.5 Conclusion
References
Chapter 13 Hybrid organic or inorganic nanomaterials for healthcare diagnostics
Abstract
13.1 Introduction
13.2 Different classes of nanomaterials and their applications
13.3 Selection criteria of nanodevices for disease diagnosis
13.4 Synthesis of smart nanomaterials
13.5 Nanomaterials characterization techniques
13.6 Application of hybrid inorganic and organic nanomaterials in healthcare diagnostics
13.7 Conclusion
References
Chapter 14 Emerging strategies in nanotheranostics: A paradigm shift
Abstract
14.1 Introduction
14.2 Nanotheranostics
14.3 Metal-based nanomaterials
14.4 Polymeric nanomaterials
14.5 Silica-based nonmaterial
14.6 Carbon nanomaterials
14.7 Composite nonmaterial
14.8 Other nanomaterials
14.9 Conclusion and future scope
References
Chapter 15 Nanoparticles in dentistry
Abstract
15.1 Introduction
15.2 Nanoparticles in dental materials
15.3 Nanoparticles in diagnostic dentistry
15.4 Nanotechnology in preventive dentistry
15.5 Nanoparticles in therapeutic dentistry
15.6 Nanoparticles in implant dentistry
15.7 Nanoparticles in sterilization and disinfection
15.8 Nanotechnology in different branches in dentistry
15.9 Conclusion
References
Chapter 16 Advanced nanomaterial for point-of-care chemotherapy
Abstract
16.1 Introduction
16.2 Challenges with conventional chemotherapy agents
16.3 Nanotherapeutics to overcome conventional chemotherapy limitations
16.4 Nanocarriers in drug delivery systems
16.4.1.3.1 Passive targeting of nanoparticles
16.4.1.3.2 Active targeting
16.5 Summary
References
Chapter 17 Drug loaded nanomaterials for hematological malignancies diagnosis and enhanced targeted therapy
Abstract
17.1 Introduction
17.2 Different nanomaterials and their fabrication for targeted drug therapy
17.3 Cancer diagnosis
17.4 Some investigated nanomaterials based imaging techniques
17.5 Clearance and toxicological investigation of nanomaterials
17.6 Challenges to cancer nanotechnology
17.7 Conclusion and future perspective
References
Chapter 18 DNA nanotechnology based point-of-care theranostics devices
Abstract
18.1 Introduction
18.2 Design and synthesis of DNA-based devices
18.3 DNA hydrogels
18.4 Characterization of DNA nanodevices
18.5 Current applications
18.6 Conclusion and future perspectives
Acknowledgements
Conflict of interest
References
Chapter 19 Current trends in theranostic approaches using nanotechnology for oral squamous cell carcinoma
Abstract
19.1 Introduction
19.2 Early diagnosis of oral cancer using nanotechnology
19.3 Enhanced treatment of oral cancer using nanotechnology
19.4 Conclusion
References
Chapter 20 Advanced nanomaterials for point-of-care diagnosis and therapy
Abstract
20.1 Introduction
20.2 Point-of-care tests and diagnosis
20.3 Nanomaterial and its classifications
20.4 Applications of nanomaterials in point-of-care diagnosis
20.5 Utilization of nanomaterials for point-of-care tests for infectious diseases
20.6 Therapeutic applications of nanomaterials
20.7 Conclusion
References
Chapter 21 Synthesis and applications of carbon nanomaterials-based sensors
Abstract
21.1 Introduction
21.2 Classification of nanosensors
21.3 Study of carbon-based sensor
21.4 Synthetic methods of carbon nanomaterials in sensing
21.5 Current applications
21.6 Conclusions
Acknowledgements
References
Chapter 22 Nanomaterials for sensors: Synthesis and applications
Abstract
22.1 Introduction
22.2 Sensors
22.3 Nanomaterials
22.4 Modification of nanomaterials as a function of size, shape, composition, doping
22.5 Applications of nanomaterials in sensor field
22.6 Summary and future perspectives
Acknowledgement
References
Chapter 23 Nanomedicines as an alternative strategy for Fungal disease treatment
Abstract
23.1 Introduction
23.2 Fungi as human pathogens
23.3 Types of fungal infections
23.4 Antifungal drugs and their mode of action
23.5 Nanomedicine/nanotherapy: An answer to antifungal resistance
23.6 Antifungal peptides as antifungal drugs/delivery system
23.7 Conclusion
References
Chapter 24 Technological advancement in nano diagnostics point of care test development for biomedical application
Abstract
24.1 Introduction
24.2 Classification of nanosensors
24.3 Synthesis
24.4 Metal and noble metal nanomaterials as nanosensors
24.5 Metal oxide nanomaterials as nanosensors
24.6 Carbon-based nanomaterials as nanosensors
24.7 Polymer nanomaterials as nanosensors
24.8 Bionanomaterials as nanosensors
24.9 Electrochemical sensors for biomedical application
24.10 Conclusion
References
Chapter 25 Smart and intelligent vehicles for drug delivery: Theranostic nanorobots
Abstract
25.1 Introduction
25.2 Magnetic fluid as a smart material
25.3 Physical properties of magnetic fluids
25.4 Engineering of magnetic fluid for biomedicine applications
25.5 Nanorobots in diagnostics
25.6 A drug delivery vehicle
25.7 Safety measurements and risks
25.8 Conclusion and prospects
References
Index

Sushma Dave

Dr. Sushma Dave received a master of science and PhD in analytical, electrochemistry, and environmental chemistry from the Biosensor Lab in the Chemistry Department of Jai Narayan Vyas University, Jodhpur. She is involved continuously in the field of higher education teaching pure, applied chemistry, cheminformatics, nanotechnology, electrochemistry, biology, solid waste management, wastewater treatment, and environmental chemistry to students of engineering and basic sciences. She also served as a Research Associate in the Soil Biochemistry and Microbiology Division, CAZRI, Jodhpur. She has published and presented over 50 papers in international and national journals, conferences and participated in various workshops and training programs. Her areas of interest are electrochemistry, biosensors environmental science, nanotechnology, biochemistry, cheminformatics, immunoinformatics, and drug repurposing.

Affiliations and expertise

Associate Professor, Department of Applied Sciences, JIET, India

Jayashankar Das

Dr. Das received his PhD in biotechnology and served as a Scientist at the IBSD, DBT, Government of India. He is the Founder and CEO of Valnizen which deals with regulatory documents and healthcare compliances and support services to African and southeast Asian countries. He has served as a Joint Director of the Gujarat State Biotechnology Mission, DST, and Joint Director to Gujarat Biotechnology Research Centre, DST, both from the Government of Gujarat. He has served as a Director of the Savli Technology and Business Incubator, DST, Government of Gujarat, India. He was actively involved in the development and implementation of various policies and action plans like biotechnology policy, innovation policy, interpole disaster management policy, start-up policy for many universities and governments. His research team is involved in addressing societal challenges via cutting-edge research, namely, the development of molecular diagnostics for infectious diseases, the development of universal vaccine candidate for emerging diseases, the development of miRNA-based targeted therapeutics, and artificial intelligence in healthcare applications.

Affiliations and expertise

Director of Research, Valnizen Healthcare Pvt Ltd, India

Sougata Ghosh

Dr. Sougata Ghosh is an Associate Professor in the Department of Microbiology, School of Science, RK University, India. He obtained his B.Sc., M.Sc. and Ph.D. in Microbiology from Savitribai Phule Pune University, India. He is also Visiting Professor at the Department of Physics, Faculty of Science, Kasetsart University, Bangkok, Thailand and Department of Chemical Engineering, Northeastern University, Boston, USA. He was principal investigator of the Department of Biotechnology (DBT), Government of India funded Foldscope Research Project. He has filed seven patents on novel nanodrugs and published more than seventy highly cited research articles in various international journals such as the International Journal of Nanomedicine, Journal of Nanobiotechnology, Journal of Nanomaterials, Journal of Nanoscience and Nanotechnology. He has edited ten books and contributed to one hundred fifty book chapters. As speaker he has addressed numerous international conferences, the most notable being ICMAR 2023 at Cebu Normal University, Philippines, 1^st JICEST-2023 at University of Jambi, Indonesia, IJAS-2019 at Harvard University, USA; ITNANO, Northeastern University, USA; ASM Biodefense, Washington D.C. USA; Nano-Bio-Med-2013, Italy and BioMicroWorld-2013, Spain. He is a reviewer for various reputed journals such as Nanoscale, Journal of Photochemistry & Photobiology, B: Biology, Journal of Diabetes Research, International Journal of Advances in Engineering Research, International Journal of Research in Science and Technology, Chemotherapy Research and Practice, Journal of Nanomedicine & Biotherapeutic Discovery, Journal of Nanomedicine and Nanotechnology, Applied Nanoscience and Arabian Journal of Chemistry. He is a life member of the Association of Microbiologists of India (AMI). His area of research consists of but is not limited to nanomedicine, microbial metabolism, bioprospecting, bioremediation, biofilms, cancer and diabetes.

Affiliations and expertise

Associate Professor in the Department of Microbiology, School of Science, RK University, India