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Advanced and Metastatic Renal Cell Carcinoma An Issue of Urologic Clinics
- 1st Edition, Volume 47-3 - July 2, 2020
- Editors: William C. Huang, Ezequiel Becher
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 5 5 4 1 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 5 5 4 2 - 9
The guest editors, Dr. William Huang and Dr. Ezequiel Becher, have assembled a state-of-the art issue devoted to Advanced and Metastatic Renal Cell Carcinoma (RCC). They have… Read more
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Request a sales quoteThe guest editors, Dr. William Huang and Dr. Ezequiel Becher, have assembled a state-of-the art issue devoted to Advanced and Metastatic Renal Cell Carcinoma (RCC). They have secured expert authors to contribute clinical reviews on the important topics involving treating and managing patients with RCC. Specific articles are devoted to the following topics: Imaging for Metastatic RCC; Adjuvant Therapy for Localized High Risk RCC; Current Standards for Therapeutic Sequencing for Advanced RCC; Role of Lymphadenectomy in patients with advanced RCC; Cytoreductive Nephrectomy in the Era of TKI/IO - Who, When and Why; Minimally Invasive Surgery for Patients with Locally Advanced and Metastatic Disease RCC; Evolving Role of Urologists in the Management of Advanced RCC; Neoadjuvant Therapy for Locally Advanced RCC; Epidemiology and Risk Assessment/Biomarkers for Patients with Advanced RCC; Radiation Therapy for Patients with Metastatic RCC; Evolving Role of Metastatectomy for Patients with Metastatic RCC; and Management of Non-Clear Cell Metastatic RCC. Readers will come away with the information they need to treat and manage patients and to improve outcomes.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Urologic Clinics of North America
- Preface
- Evolving Role of Urologists in the Management of Advanced Renal Cell Carcinoma
- Key points
- Introduction
- Prognostication
- Management of locally advanced disease
- Management of metastatic disease
- Summary
- Imaging for Metastatic Renal Cell Carcinoma
- Key points
- Introduction
- Role of diagnostic radiology in evaluation for metastatic disease: computed tomography and MRI
- Organ-specific evaluation for metastasis
- Imaging assessment to response to therapy
- Other imaging modalities
- Summary
- Epidemiology, Risk Assessment, and Biomarkers for Patients with Advanced Renal Cell Carcinoma
- Key points
- Introduction
- Risk-stratification models
- Biomarkers in advanced renal cell carcinoma
- Summary
- Sequencing Therapies for Metastatic Renal Cell Carcinoma
- Key points
- Introduction
- Clear cell renal cell carcinoma first-line treatment options
- Further-line treatment
- Summary
- Management of Metastatic Renal Cell Carcinoma with Variant Histologies
- Key points
- Introduction
- Main biological features of variant histology renal cell carcinoma
- The role of nephrectomy in metastatic variant histology renal cell carcinoma
- Systemic therapy for variant histology renal cell carcinoma
- Perspectives
- Neoadjuvant Therapy for Locally Advanced Renal Cell Carcinoma
- Key points
- Introduction
- Methods
- Rationale for neoadjuvant therapy
- Outcomes of neoadjuvant therapy studies
- Concerns with neoadjuvant therapy
- Predicting response to neoadjuvant therapy
- Our Current Practice
- Future directions
- Summary
- Adjuvant Therapy for Localized High-Risk Renal Cell Carcinoma
- Key points
- Introduction
- Patterns of recurrence, risk factors, and risk stratification
- Concepts underlying adjuvant therapy
- Adjuvant trials of classic immunotherapy agents
- Adjuvant trials of vascular endothelial growth factor–targeted agents
- Summarizing the evidence for adjuvant treatment with tyrosine kinase inhibitors/mammalian target of rapamycin inhibitors
- Checkpoint inhibition in the localized disease state
- Summary
- Cytoreductive Nephrectomy in the Era of Tyrosine Kinase and Immuno-Oncology Checkpoint Inhibitors
- Key points
- Introduction
- Benefit of cytoreductive therapy alone in metastatic renal cell carcinoma
- Cytokine-based immunotherapy era
- Risk stratification and patient selection
- Vascular endothelial growth factor–targeted therapy era
- Active surveillance
- New era—immuno-oncology
- Cytoreductive nephrectomy in metastatic non–clear cell metastatic renal cell carcinoma
- European Association of Urology recommendations and National Comprehensive Cancer Network guidelines
- Take-home points and clinical recommendations
- The Role of Lymphadenectomy in Patients with Advanced Renal Cell Carcinoma
- Key points
- Introduction and historical perspective
- Lymph node dissection templates
- Staging role of lymph node dissection
- Survival benefit of lymph node dissection in M0 renal cell carcinoma
- Survival benefit of lymph node dissection in M1 renal cell carcinoma
- Renal cell carcinoma with isolated lymph node metastases (pN1 M0 renal cell carcinoma)
- Morbidity of lymph node dissection
- Summary
- The Evolving Role of Metastasectomy for Patients with Metastatic Renal Cell Carcinoma
- Key points
- Introduction
- Utilization of metastasectomy for metastatic renal cell carcinoma
- Evidence for metastasectomy in metastatic renal cell carcinoma
- Patient selection
- Individual metastatic sites
- Morbidity of treatments for metastatic renal cell carcinoma
- Radiation or percutaneous thermal ablation for local metastatic renal cell carcinoma treatment
- Cost of local versus systemic therapies
- Summary
- Minimally Invasive Surgery for Patients with Locally Advanced and/or Metastatic Renal Cell Carcinoma
- Key points
- Introduction
- History of minimally invasive surgery for renal masses
- Evidence and potential benefits
- Robotic versus laparoscopic surgery
- Cases of renal vein and/or inferior vena cava involvement
- Retroperitoneal lymph node dissection and adenopathy
- Critiques and potential drawbacks
- Cytoreductive nephrectomy in metastatic renal cell carcinoma: a role for minimally invasive surgery?
- Proper patient selection for minimally invasive surgery in advanced renal cell carcinoma
- New York University experience on minimally invasive surgery for advanced renal cell carcinoma
- Summary
- Radiation Therapy for Patients with Advanced Renal Cell Carcinoma
- Key points
- Introduction
- Radiotherapy in locally advanced renal cell carcinoma
- Radiotherapy in metastatic renal cell carcinoma
- Combination of radiotherapy with systemic therapy and future directions
- Summary
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 47-3
- Published: July 2, 2020
- Imprint: Elsevier
- Hardback ISBN: 9780323755412
- eBook ISBN: 9780323755429
WH
William C. Huang
Affiliations and expertise
Tisch Hospital,
New York Langone Medical Center,EB
Ezequiel Becher
Affiliations and expertise
NYU Langone Health,
New York,