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Elsevier

Adult Hydrocephalus and Disorders of CSF Dynamics

  • 1st Edition - April 1, 2027
  • Latest edition
  • Editors: Benjamin D. Elder, Jeremy Cutsforth-Gregory
  • Language: English

Adult Hydrocephalus and Disorders of CSF Dynamics reviews the pathophysiology, evaluation, differential diagnosis, management and treatment of adult hydrocephalus and disord… Read more

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Description

Adult Hydrocephalus and Disorders of CSF Dynamics reviews the pathophysiology, evaluation, differential diagnosis, management and treatment of adult hydrocephalus and disorders of cerebrospinal fluid (CSF). The introductory section begins with the anatomy and physiology of the cerebrospinal fluid system, with a review of adult hydrocephalus management, including longitudinal care and management of comorbidities. The following technical section devoted to shunt design and development, and then management of patients with idiopathic normal pressure hydrocephalus (iNPH). Coverage includes differential diagnosis and treatment of iNPH, as well as common presentations, neuroimaging, genetic studies, CSF biomarkers, and using artificial intelligence. Confirmatory testing discusses high volume lumbar punctures, lumbar drainage trials, and CSF infusion testing. Medical and surgical treatments are reviewed with expected functional outcomes. A subsequent section discusses secondary normal pressure hydrocephalus, caused by other etiologies such as hemorrhage, tumors, or infection, and covers longstanding overt ventriculomegaly (LOVA), management of adult patients who were shunted as children, and Chiari malformations. The book concludes with high and low pressure CSF dynamics disorders, including idiopathic intracranial hypertension and secondary intracranial hypertension, followed by a review of the medical, surgical, and ophthalmological management of these disorders.

Key features

  • Introduces pathophysiology and clinical presentation of adult hydrocephalus
  • Discusses genetics, diagnostic neuroimaging, and biomarkers
  • Reviews normal, low, and high-pressure cerebrospinal fluid disorders
  • Presents medical and surgical treatments with expected outcomes
  • Includes principles of shunt design

Readership

Practicing neurologists, neurosurgeons, and neuro-ophthalmologists as well as academic researchers and medical students

Table of contents

1. Anatomy and physiology of the normal cerebrospinal fluid system

2. Healthcare economics and epidemiology of hydrocephalus

3. Components of a comprehensive cerebrospinal fluid dynamics clinic

4. Longitudinal care for patients with hydrocephalus

5. Shunt design and operation

6. Shunt design modifications to prevent obstruction

7. Animal models of hydrocephalus Section

8. History of the diagnosis and treatment of idiopathic normal pressure hydrocephalus

9. Differential diagnosis and spinal and neuromuscular comorbidities in patients with idiopathic normal pressure hydrocephalus

10. Clinical presentation and pathophysiology of idiopathic normal pressure hydrocephalus

11. Genetics of idiopathic normal pressure hydrocephalus

12. Diagnostic neuroimaging of idiopathic normal pressure hydrocephalus

13. Using artificial intelligence to diagnose idiopathic normal pressure hydrocephalus

14. Temporary CSF removal in the presurgical evaluation of idiopathic normal pressure hydrocephalus

15. Cerebrospinal fluid infusion testing in the evaluation of idiopathic normal pressure hydrocephalus

16. Cerebrospinal fluid biomarkers in adult hydrocephalus

17. Surgical procedures for the treatment of idiopathic normal pressure hydrocephalus

18. Short- and long-term complications of surgery for idiopathic normal pressure hydrocephalus

19. Functional outcomes of surgical treatment of idiopathic normal pressure hydrocephalus

20. Secondary normal pressure hydrocephalus

21. Longstanding overt ventriculomegaly (LOVA) and obstructive etiologies of hydrocephalus in adults

22. Longitudinal care of adult patients with congenital hydrocephalus

23. Chiari malformations and syrinx Section 5: High and Low Pressure Cerebrospinal Fluid Disorders

24. Clinical presentations and diagnosis of idiopathic intracranial hypertension

25. Secondary causes of intracranial hypertension (pseudotumor cerebri syndrome)

26. Medical and surgical treatment of idiopathic intracranial hypertension

27. Ophthalmological management of patients with idiopathic intracranial hypertension

28. Clinical presentations of spontaneous intracranial hypotension

29. Diagnostic neuroimaging of suspected spinal cerebrospinal fluid leaks

30. Treatment of spontaneous spinal cerebrospinal fluid leaks and CSF-venous fistulas

Product details

  • Edition: 1
  • Latest edition
  • Published: April 1, 2027
  • Language: English

About the editors

BE

Benjamin D. Elder

Dr. Benjamin Elder is a Professor of Neurosurgery, Orthopedics, and Biomedical Engineering at the Mayo clinic. He has an interest in better understanding idiopathic normal pressure hydrocephalus (iNPH). In collaboration with a team of neurologists, neuroradiologists, neuro-ophthalmologists and biomedical engineers, Dr. Elder is investigating improved imaging and functional diagnostic tests for the diagnosis and characterization of iNPH. Additionally, his group is working to develop new tools to assess and optimize the gait apraxia in patients with iNPH, and explore the clinical and functional outcomes of patients treated with CSF diversion procedures.

Affiliations and expertise
Professor of Neurosurgery, Orthopedics, and Biomedical Engineering, Mayo Clinic, USA

JC

Jeremy Cutsforth-Gregory

Dr. Jeremy Cutsforth-Gregory is an Associate Professor of Neurology at the Mayo Clinic in Rochester, Minnesota, working in the Division of Neurologic Education, where he completed his medical training and joined the staff in 2016. His clinical practice and research interests span general neurology education, autonomic disorders, and abnormal CSF dynamics. He is a founding member and director of the CSF Dynamics Clinic, collaborating across multiple departments to advance understanding and treatment of low and high CSF pressure disorders.

Affiliations and expertise
Associate Professor of Neurology, Mayo Clinic, USA