Adiponectin

Former Editors

Contributors

Preface

Chapter One Lifestyle Factors Increasing Adiponectin Synthesis and Secretion

1 Introduction

2 Lifestyle Factors That Increase Adiponectin Synthesis and Secretion

3 Mechanisms for Lifestyle-Mediated Effects on Adiponectin

4 Conclusions

Chapter Two Molecular Tools to Characterize Adiponectin Activity

1 Introduction

2 Analysis of the Cellular Biology

3 Protein Structures

4 Searching for New Interaction Partners

5 Signaling Cascades and Physiological Effect

6 Conclusion

Chapter Three Nutritional and Hormonal Modulation of Adiponectin and its Receptors adipoR1 and adipoR2

1 Introduction

2 Nutritional Regulation of Adiponectin and Adiponectin Receptors

3 Hormonal Regulation of Adiponectin and Adiponectin Receptors

4 Conclusion

Chapter Four Regulation and Function of Adiponectin Receptors in Skeletal Muscle

1 Introduction

2 Adiponectin and Adiponectin Receptors

3 Adiponectin Signaling and Function in Skeletal Muscle

4 Transcriptional Regulation of AdipoRs in Skeletal Muscle Under Different Physiological and Pathophysiological Conditions

5 Molecular Mechanisms Regulating Muscle AdipoRs Transcription

6 Posttranscriptional Regulation of AdipoRs in Skeletal Muscle

7 Concluding Remarks

Chapter Five Screening for Adiponectin Secretion Regulators

1 Introduction

2 PPARγ-Dependent Adiponectin Secretion Regulators

3 PPAR γ-Independent Adiponectin Secretion Regulators

4 Other Adiponectin Secretion Regulators

5 Conclusions

Chapter Six Adiponectin and PPARγ

1 PPARγ Activity Correlates with Adiponectin Hormone Levels

2 PPARγ Regulates Adiponectin Gene Transcription

3 PPARγ Regulates Adiponectin Hormone Secretion

4 PPARγ and Adiponectin Regulate Similar Physiological Pathways

5 Conclusion

Chapter Seven Glucocorticoid Effects on Adiponectin Expression

1 Introduction

2 Glucocorticoids and Their Effects on Gene Expression

3 Effects of GC and Adiponectin on Energy Metabolism

4 In Vitro and Animal Studies on the Effects of GC on Adiponectin Expression

5 Clinical Studies on the Effects of GC on Adiponectin Expression

6 Other Hormones, Factors, and Conditions That Regulate Adiponectin Expression and Their Relationship to GC

7 Potential Reasons for Contradictory Results on the Effects of GC on Adiponectin Expression and Methods That can be Useful in Gaining Better Insight About This Regulation

8 Conclusion

Chapter Eight Adiponectin and Reproduction

1 Introduction

2 Adiponectin and Adiponectin Signaling

3 Adiponectin: Main Functions in Human

4 Adiponectin and Steroidogenesis

5 Adiponectin and Placental Functions

6 Adiponectin and Pregnancy-Associated Pathologies

7 Conclusions and Perspectives

Chapter Nine Adiponectin and Its Receptors in Preimplantation Embryo Development

1 Introduction

2 Adiponectin and Fertility

3 Overview of Preimplantation Embryo Development

4 Expression of Adiponectin and Adiponectin Receptors in Oocytes and Preimplantation Embryos

5 Potential Roles of Adiponectin in Oocyte and Early Embryo Development

6 Conclusions

Chapter Ten Adiponectin and the Control of Female Reproductive Functions

1 Introduction

2 Adiponectin in Ovarian Functions

3 Adiponectin in Pregnancy

4 Adiponectin Action on the Central Nervous System and the Pituitary Gland

5 Conclusion

Chapter Eleven Adiponectin in the Heart and Vascular System

1 Introduction to Adiponectin

2 Adiponectin and CVD in Humans

3 Protective Effects of Adiponectin in the Cardiovascular System: Evidence from Rodent and In Vitro Studies

4 Conclusions/Future Questions

Chapter Twelve Adiponectin Interactions in Bone and Cartilage Biology and Disease

1 Introduction

2 Adipose, Bone, and Cartilage Relationships: Observations in Humans

3 Adiponectin, Bone, and Cartilage: Interactions in Humans

4 Adiponectin, Bone, and Cartilage: Experimental Observations

5 Conclusions

Chapter Thirteen Lipid-Lowering Drugs and Circulating Adiponectin

1 Introduction

2 Adiponectin

3 Statins

4 Fibrates

5 Niacin

6 Omega-3 Fatty Acids

7 Conclusions

Chapter Fourteen Adiponectin and Interleukin-6 in Inflammation-Associated Disease

1 Introduction

2 Biological Actions and Signaling Pathways Activated by Adiponectin

3 Interaction Between Adiponectin and IL-6 in Regulating Diabetic State

4 Interaction Between Adiponectin and IL-6 in Regulating Cardiovascular Disease

5 Interaction Between Adiponectin and IL-6 in Regulating Autoimmune Disease

6 Conclusion

Chapter Fifteen New Insights into Anticarcinogenic Properties of Adiponectin

1 Introduction

2 Adiponectinemia

3 Adiponectin and Breast Cancer Risk

4 Adiponectin as Therapeutic Target

5 Conclusion

Chapter Sixteen Adiponectin

1 Introduction

2 Structure of APN: Similarity to Surfactant Proteins

3 Expression and Regulation of APN in the Lung

4 COPD-Like Phenotype in APN-KO Mice

5 Mechanisms of COPD-Like Phenotype in APN-KO Mice

6 Therapeutic Potential of APN

7 Conclusion

Index