Adenosine Receptors in Neurodegenerative Diseases

1st Edition - March 10, 2017
Editors: David Blum, Luisa V. Lopes
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 3 7 2 4 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 3 7 4 5 - 4

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeut… Read more

Purchase options

Institutional subscription on ScienceDirect

Request a sales quote

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field.

Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.

Section I: Physiology

Chapter 1. Adenosine Receptor Biology in the Central Nervous System

Abstract
Sources of Adenosine in the CNS
Receptor Subtypes and Their CNS Distribution
Crosstalk With Other Receptors
Adenosine and CNS Diseases
Recent Clinical Trials
References

Chapter 2. Adenosine Signaling Throughout Development

Abstract
Introduction
Effects of Adenosine Signaling and Its Dysfunction in CNS
Effects of Adenosine in Oligodendrocytes Development
Effects of Adenosine on Cardiovascular System During Embryogenesis
Postnatal Effects of Adenosine on Cardiovascular System
Postnatal Effect of Adenosine on Respiratory System
Use of Methylxanthines in Premature Babies
Postnatal Effects of Adenosine on the Genitourinary System
Postnatal Effect of Adenosine on the Enteric System
Postnatal Effect of Adenosine on Other Systems
Conclusion
References

Chapter 3. Influence of Adenosine on Synaptic Excitability

Abstract
Introduction
Molecular & Physiological Mechanisms
Implications for Epilepsy
Conclusions and Outlook
Acknowledgments
References

Chapter 4. Regulation of Synaptic Transmission by Adenosine at the Neuromuscular Junction

Abstract
Introduction
Neuromuscular Junction
Adenosine as a Neuromodulator at the Neuromuscular Junction
Conclusions
References

Chapter 5. Gene Regulation of Adenosine A_2A Receptors in the Central Nervous System

Abstract
General Introduction
A_2AR Promoter and Gene Structure
Epigenetics of ADORA2A
Use of DNA Methylating Agents as a Therapeutic Tool
The Dual Codon Properties of the A_2AR Gene
Concluding Remarks
Acknowledgments
References

Section II: Pathology

Chapter 6. Sleep, Adenosine, and Neurodegeneration

Abstract
Sleep Phenomenology and Adenosine
Sleep and Adenosine Changes Across Normal Ageing
Sleep Changes in Alzheimer’s Disease
Mechanisms of Alzheimer’s Disease Influence on Sleep
Changes in ADORA1 and ADORA2 Expression
Association of Alzheimer’s Disease Biomarkers and Sleep
Role of Sleep Loss in Alzheimer’s Disease
Sleep Changes in Parkinson’s Disease
Parkinson’s Disease Role in Sleep Pathology
Role of Sleep Loss in Parkinson’s Disease Pathology
Treatment Related Issues
Summary
References

Chapter 7. Neuronal vs Glial Cell Contribution to Adenosine A_2A Receptor-Induced Neurodegeneration

Abstract
Neurodegeneration and Neurodegenerative Diseases
Role of A_2A Receptors in Neurodegeneration
Conclusions
References

Chapter 8. Adenosine and Oxygen/Glucose Deprivation in the Brain

Abstract
Introduction
Adenosine is Released by Ischemia and Stimulate All P1 Receptor Subtypes
Role of Adenosine Receptors in Ischemia
Conclusions
Acknowledgments
References

Chapter 9. Adenosine Receptors and Memory Disorders

Abstract
Alzheimer’s Disease
Caffeine May Protect Against Cognitive Decline and AD
Caffeine, Adenosine Receptor and AD Lesions
Conclusion
Acknowledgments
References

Chapter 10. Control of Motor Function by Adenosine A_2A Receptors in Parkinson’s and Huntington’s Disease

Abstract
Introduction
Basal Ganglia Circuitry
Adenosine A_2A Receptor Antagonists
Parkinson’s Disease
Effect of A_2A Receptor Antagonists on Motor and Sensorimotor Deficits
Modulation of Adenosine A_2A Receptors and Interaction With the Other Neurotransmitter Systems
Adenosine A_2A Receptors and Huntington’s Disease
Conclusions
References

Chapter 11. Adenosine Receptors Oligomers in Parkinson’s Disease

Abstract
Introduction
Adenosine Receptors in the Brain
Adenosine Receptor-Containing Oligomers
Parkinson’s Disease and Adenosine Receptor Oligomers: Impact on Pharmacotherapy
Concluding Remarks
Acknowledgments
References

Chapter 12. Adenosine Control of Striatal Function—Implications for the Treatment of Apathy in Basal Ganglia Disorders

Abstract
Introduction
Dopamine Control of Striatal Function
Differential Dopamine Control of the Direct and Indirect Striatal Efferent Pathways, the “Go” and “NoGo” Pathways
Differential Adenosine Control of the “Go” and “NoGo” Pathways. The Adenosine–Dopamine Receptor Heteromers
Adenosine Control of the Striatal Glutamate Terminal. The A₁R–A_2AR Heteromer
Dopamine and Striatal Dysfunction. Apathy Versus Akinesia
Targeting Adenosine Receptor Heteromers for the Treatment of Apathy
Acknowledgments
References

David Blum

Dr. David Blum is Research Director at Inserm in the “Alzheimer & Tauopathies” laboratory, a founder unit of the Jean-Pierre Aubert Research Centre (UMR-S 1172; Lille, France). His group is particularly focused on how environmental factors affect brain disorders with a particular interest towards caffeine. His current topic in this field relates to the impact of adenosine receptor modulation in neurological and neurodegenerative disorders as well as to the better understanding of molecular effects of caffeine into the brain. David has also a strong interest to translate his findings towards clinical studies, epidemiological and genetics. David graduated at Strasbourg University, France; obtained his PhD in Neurosciences at Grenoble University, France in 1999; and developed post-doctoral research experience at ULB, Brussels, Belgium. He has been recruited as senior researcher at Inserm in 2006. His main contributions includes the description of the complex role of adenosine receptors in Huntington’s disease and the first demonstration of regulatory role of A2A receptor contribution in Tauopathies (with Dr. Lopes). David authors more that 90 papers with more that 2500 citations, including top Neuroscience Journals as Lancet Neurology, Molecular Psychiatry, Journal of Neuroscience, Neurobiology of Aging or Human Molecular Genetics. David serves in several editorial boards as associate editors and as expert for most Neuroscience journals and fundings agencies in his field.

Affiliations and expertise

Inserm UMR-1172 and Université de Lille, Lille, France

Luisa V. Lopes

Luísa V. Lopes is a Group leader@iMM Lisboa, Portugal. Her current work focuses on understanding the mechanisms inducing the "early-aging" of the cognitive function. The team has extensively provided evidence for an important contribution of adenosine receptors in pathophysiological context, and their impact in noxious brain conditions such as stress, aging and neurodegeneration, being awarded by FEBS, FENS and EMBO. Luisa graduated in Lisbon in 1998 in Biochemistry and then pursued a PhD in Neurosciences being trained in the University of Cambridge, UK and at the Karolisnka Institute, Sweden. She acquired postdoctoral experience in a company setting (Nestlé Research Center; Switzerland) studying brain-gut interactions with particular focus on early-life stress. Luisa established her own research group in 2013 as recipient of an Investigator FCT position. Her contribution includes providing the crucial first evidence of a possible glucocorticoid-adenosine link in Alzheimer’s disease (with D. Blum) following previous groundwork suggesting circadian disorders as a trigger for accelerated cognitive loss. She has authored more than 40 papers in international peer-reviewed journals with over 1000 citations. These include top journals in the field of neuroscience, such as Molecular Psychiatry, Neurobiology of Ageing, Journal of Neuroscience, as a senior author; including an award publication in TINS. Luisa has also served as a Board Member of Portuguese Society for Neuroscience and got an award from DANA Alliance for her work in raising public awareness for brain research.

Affiliations and expertise

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Portugal

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Adenosine Receptors in Neurodegenerative Diseases

Purchase options

Institutional subscription on ScienceDirect

David Blum

Luisa V. Lopes