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Acute Respiratory Distress Syndrome, An Issue of Clinics in Chest Medicine
- 1st Edition, Volume 45-4 - October 22, 2024
- Editors: Sarina Sahetya, Eddy Fan, Shannon M. Fernando
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 4 7 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 1 4 8 - 6
In this issue of Clinics in Chest Medicine, guest editors Drs. Eddy Fan, Shannon M. Fernando, and Sarina Sahetya bring their considerable expertise to the topic of Acute Respirato… Read more
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Request a sales quoteIn this issue of Clinics in Chest Medicine, guest editors Drs. Eddy Fan, Shannon M. Fernando, and Sarina Sahetya bring their considerable expertise to the topic of Acute Respiratory Distress Syndrome. Top experts discuss environmental risk factors for ARDS; genetic and molecular risk factors for ARDS; biomarkers of ARDS; cellular mechanisms of lung injury; ARDS phenotypes and precision medicine; and more.
- Contains 19 relevant, practice-oriented topics including prone positioning; steroids and immunomodulatory therapy for ARDS; early rehabilitation in ARDS; extracorporeal support for ARDS; long-term outcomes/PICS after ARDS; ARDS in the immunocompromised patient; future directions; and more.
- Provides in-depth clinical reviews on acute respiratory distress syndrome, offering actionable insights for clinical practice.
- Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Chest Medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Definitions of Acute Respiratory Distress Syndrome: Present Recommendations and Challenges
- Key points
- Background
- Challenges with definitions
- The global definition of the acute respiratory distress syndrome
- Discussion
- Input from global critical care societies
- Future research
- Summary
- Clinics care points
- Environmental Risk Factors for Acute Respiratory Distress Syndrome
- Key points
- Introduction
- Air pollution
- Cigarette smoke
- Alcohol
- Summary
- Clinics care points
- Biomarkers of Acute Respiratory Distress Syndrome: Current State and Future Prospects
- Key points
- Introduction
- Pathobiologic origins of acute respiratory distress syndrome biomarkers
- Molecular phenotyping
- Ventilator-induced lung injury
- Future directions for biomarker discovery
- Prospective biomarker-driven trials: the next frontier
- Summary
- Clinics care points
- Cellular Mechanisms of Lung Injury: Current Perspectives
- Key points
- Introduction
- Alveolar-capillary barrier
- Endothelial injury mechanisms
- Epithelial injury mechanisms
- Conclusions and future directions
- Clinics care points
- Precision Medicine in Acute Respiratory Distress Syndrome: Progress, Challenges, and the Road ahead
- Key points
- Introduction
- A brief primer on precision medicine approaches
- Clinical heterogeneity in acute respiratory distress syndrome
- Physiologic heterogeneity of acute respiratory distress syndrome
- Biologic heterogeneity of acute respiratory distress syndrome
- Lessons learned from coronavirus disease 2019
- Plausible pathways to precision
- Summary
- Clinics care points
- Noninvasive Respiratory Support in Acute Respiratory Distress Syndrome
- Key points
- An overview on noninvasive respiratory support in acute respiratory distress syndrome
- Noninvasive respiratory support modalities
- Setup for continuous positive airway pressure and pressure support: flow generators, ventilators, and interfaces
- Failure of noninvasive respiratory support
- Sedation during noninvasive respiratory support
- Summary
- Clinics care points
- Lung and Diaphragm Protection During Mechanical Ventilation in Patients with Acute Respiratory Distress Syndrome
- Key points
- Introduction
- Ventilator-induced lung injury
- Ventilator-induced diaphragm dysfunction
- Advantages and disadvantages of spontaneous breathing during mechanical ventilation
- Therapeutic strategies
- Summary
- Clinics care points
- Neuromuscular Blockade in Adult Respiratory Distress Syndrome
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Steroids and Immunomodulatory Therapies for Acute Respiratory Distress Syndrome
- Key points
- Introduction
- Dysregulated immune responses in acute respiratory distress syndrome
- Immunomodulatory therapies in acute respiratory distress syndrome
- Future directions
- Summary
- Clinics care points
- Early Rehabilitation in Acute Respiratory Distress Syndrome
- Key points
- Introduction
- Background
- Discussion
- Benefits and risks of rehabilitation in patients with acute respiratory distress syndrome
- Recommendations for the implementation of early rehabilitation in acute respiratory distress syndrome
- Summary
- Clinics care points
- Extracorporeal Support for Acute Respiratory Distress Syndrome
- Key points
- Introduction
- Extracorporeal life support physiology, cannulation strategies, and configurations
- Extracorporeal life support and ultra-lung-protective ventilation: rationale and mechanisms
- Extracorporeal life support for severe acute respiratory distress syndrome: indications and evidence
- Applications of extracorporeal life support in less severe forms of acute respiratory distress syndrome
- Management of the patient with acute respiratory distress during extracorporeal life support
- Future directions of extracorporeal life support for acute respiratory distress syndrome
- Ethical considerations
- Summary
- Clinics care points
- Updates on Post-Intensive Care Syndrome After Acute Respiratory Distress Syndrome: Epidemiology, Core Outcomes, Interventions, and Long-Term Follow-Up
- Key points
- Introduction
- Genesis of the “post-intensive care syndrome” term
- Epidemiology of impairments after acute respiratory distress syndrome and other critical illnesses
- Risk factors
- Core outcome set for intensive care unit survivorship research
- Post-intensive care syndrome family
- Prevention and treatment
- Readmissions
- Future directions
- Summary
- Clinics care points
- Acute Respiratory Distress Syndrome in the Immunocompromised Patient
- Key points
- Who is immunosuppressed?
- Why should the intensivist know about immunosuppressed patients?
- Admission rules and survival rates
- Finding an etiology is essential
- Antimicrobial therapy
- General support and specific treatment of acute respiratory failure in immunosuppressed patients
- Intensity of care in immunosuppressed patients
- Future directions–open questions
- Summary
- Clinics care points
- Future Directions in Therapies for Acute Respiratory Distress Syndrome
- Key points
- Background
- Pathogenesis informed pharmacotherapy
- Hyperinflammation targeted treatments
- Endothelial dysfunction targeted treatments
- Epithelial injury targeted treatments
- Discussion
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 45-4
- Published: October 22, 2024
- Imprint: Elsevier
- Hardback ISBN: 9780443131479
- eBook ISBN: 9780443131486
SS
Sarina Sahetya
Affiliations and expertise
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandEF
Eddy Fan
Affiliations and expertise
Associate Professor of Medicine, Interdepartmental Division of Critical Care Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto, Medical Director, Extracorporeal Life Support (ECLS) Program, Scientist, TGH Research InstituteSF
Shannon M. Fernando
Affiliations and expertise
Division of Critical Care, Department of Medicine, Clinical Epidemiology Program, Ottawa Hospital, Research Institute, Department of Critical Care, Lakeridge Health, Corporation, Oshawa