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Acute Kidney Injury, An Issue of Critical Care Clinics
- 1st Edition, Volume 37-2 - March 25, 2021
- Editors: John Kellum, Dana Fuhrman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 6 1 6 8 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 6 1 6 9 - 7
This issue of Critical Care Clinics, guest edited by Drs. John Kellum and Dana Fuhrman, focuses on Acute Kidney Injury. This is one of four issues each year selected by the se… Read more
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Request a sales quoteThis issue of Critical Care Clinics, guest edited by Drs. John Kellum and Dana Fuhrman, focuses on Acute Kidney Injury. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Acute Kidney Injury and Disease, AKI in Cardiac Surgery, AKI in Sepsis, Hepatorenal Disease, Cardiorenal Syndrome, Onconephrology, Renal Functional Reserve and more.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Defining Acute Kidney Injury
- Key points
- Introduction
- History: acute renal failure to acute kidney injury
- Defining acute kidney injury
- Relationship to clinical outcomes
- Electronic alerts
- Biomarkers in acute kidney injury
- Persistent acute kidney injury and acute kidney disease
- Clinics care points
- Acute Kidney Injury in Cardiac Surgery
- Key points
- Introduction
- Discussion
- Risk assessment
- Interventions
- Summary
- Clinics care points
- Sepsis-Associated Acute Kidney Injury
- Key points
- Introduction
- Definitions
- Epidemiology
- Pathophysiology of sepsis-associated acute kidney injury
- Diagnosis
- Recovery from sepsis-associated acute kidney injury and long-term follow-up
- Prevention and treatment of sepsis-associated acute kidney injury
- Summary
- Clinics care points
- Nephrotoxin Stewardship
- Key points
- Introduction and nephrotoxin stewardship definition
- Goal 1: medication safety
- Goal 2: kidney health
- Goal 3: avoiding unnecessary costs
- Summary
- Clinics care points
- Hepatorenal Syndrome
- Key points
- Introduction
- Assessment of kidney function in cirrhosis
- Definitions
- Pathophysiology
- Cause of kidney dysfunction
- Prevention and treatment of hepatorenal syndrome
- Post–liver transplant acute kidney injury
- Summary
- Clinic care points
- Cardiorenal Syndrome
- Key points
- Introduction: the definition of cardiorenal syndrome
- Cardiorenal syndrome in adults
- Cardiorenal syndrome in patients supported by artificial heart support and after heart transplantation
- Cardiorenal syndrome in children
- Summary
- Neonatal Acute Kidney Injury: Understanding of the Impact on the Smallest Patients
- Key points
- Introduction
- Case scenario 1
- Prematurity, low birthweight, and acute kidney injury
- High-risk exposures for preterm babies
- Nephrotoxic medication exposure
- Acute kidney injury diagnosis and biomarkers
- Novel acute kidney injury biomarkers
- Case scenario 2
- Acute kidney injury and the interplay with other organ systems
- Fluid balance and fluid overload
- Neonatal acute kidney injury and long-term outcomes
- Current developments in neonatal acute kidney injury management: caffeine and continuous renal replacement therapy
- Summary
- Clinics care points15,69,70
- Onconephrology
- Key points
- Introduction
- Epidemiology
- Discussion
- Prerenal
- Intrinsic
- Glomerular and paraneoplastic causes
- Tubulointerstitial causes
- Vascular or thrombotic microangiopathy
- Postrenal
- Summary
- Clinics care points
- Biomarkers in Acute Kidney Injury
- Key points
- Introduction
- Limitations of Current Acute Kidney Injury Diagnosis
- Biomarkers and the Continuum of Acute Kidney Injury
- Summary
- Clinics care points
- The Role of Renal Functional Reserve in Predicting Acute Kidney Injury
- Key points
- Introduction
- Postulated mechanisms for renal functional reserve
- Methods used to quantify renal functional reserve
- A renewed interest in renal functional reserve
- Limitations to the routine use of renal functional reserve in routine clinical care
- Summary
- clinics care points
- Starting Kidney Replacement Therapy in Critically III Patients with Acute Kidney Injury
- Key points
- Introduction
- The clinical dilemma of when to start kidney replacement therapy
- Kidney replacement therapy and clinical outcomes
- Kidney replacement therapy and coronavirus disease 2019
- Definitions of timing for starting kidney replacement therapy
- Rationale for an early strategy to starting kidney replacement therapy
- Rationale for a conservative strategy to kidney replacement therapy initiation
- Current clinical practice guideline recommendations
- Clinical trial evidence on timing of starting kidney replacement therapy
- Implications for clinicians
- Existing knowledge gaps
- Summary
- Clinics care points
- Kidney Replacement Therapy for Fluid Management
- Key points
- Introduction
- Fluid balance and outcomes
- Principles of volume management using kidney replacement therapy
- Vascular refill during net ultrafiltration
- Association of net ultrafiltration rate with outcomes
- Areas of uncertainty and directions for future research
- Summary
- Clinics care points
- Acute Kidney Disease to Chronic Kidney Disease
- Key points
- Introduction
- Epidemiology of chronic kidney disease
- Epidemiology of acute kidney injury
- Acute kidney disease after acute kidney injury
- Pathophysiology of kidney repair and regeneration
- Epidemiology of acute kidney disease
- Management of acute kidney disease
- Summary
- Clinics care points
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 37-2
- Published: March 25, 2021
- Imprint: Elsevier
- Hardback ISBN: 9780323761680
- eBook ISBN: 9780323761697
JK
John Kellum
Dr. Kellum is a Distinguished Professor of Critical Care Medicine, Medicine, Bioengineering and Clinical and Translational Science and holds an Endowed Chair in Critical Care Research from the University of Pittsburgh. He is currently on leave and serving as the Chief Medical Officer for Spectral Medical, a late-stage medical device company developing diagnostics and therapeutics for sepsis. Dr. Kellum received his medical degree from the Medical College of Ohio in 1984. His postgraduate training includes an internship and residency in Internal Medicine at the University of Rochester, NY, and a Fellowship in Critical Care Medicine at the University of Pittsburgh. His research interests span various aspects of Critical Care Medicine but center in critical care nephrology, sepsis, and multi-organ failure. He has authored more than 750 publications, has won several teaching awards teaching, has given more than 500 seminars and invited lectures worldwide.
Affiliations and expertise
Professor of Critical Care Medicine, Bioengineering and Clinical and Translational Science, UPMC