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Elsevier

Accurate Results in the Clinical Laboratory

A Guide to Error Detection and Correction

  • 3rd Edition - May 1, 2027
  • Latest edition
  • Editors: Amitava Dasgupta, Jorge L. Sepulveda
  • Language: English

Accurate Results in the Clinical Laboratory:A Guide to Error Detection and Correction, 3rd Edition continues to be an in-depth resource of common sources of errors in clinic… Read more

Description

Accurate Results in the Clinical Laboratory:A Guide to Error Detection and Correction, 3rd Edition continues to be an in-depth resource of common sources of errors in clinical laboratories. It provides strategies to avoid pre-analytical errors, including patient preparation, specimen collection, and anticoagulant use and Insights into major sources of pre-analytical errors such as sample processing and specimen misidentification. This book is an essential reference for professionals and students aiming to enhance accuracy and reliability in clinical laboratory testing. This new edition has fully updated chapters and new information on how to eliminate lab errors including avoiding post analytic phase of reporting results through laboratory informatics system. This is a guide for laboratory professionals and clinicians regarding sources of errors and misinterpretation in the clinical laboratory and how to resolve such errors and identify discordant specimens. Accurate laboratory result interpretation is essential for patient safety. This book is intended as a practical guide to laboratory professionals and clinicians who deal with erroneous results on a regular basis.

Key features

  • Includes detailed discussions on immunoassay design and interferences, including the prozone effect and biotin interference
  • Covers modern challenges in routine clinical chemistry testing for small molecules, proteins, enzymes, endocrinology, and tumor markers
  • Provides best practices in clinical laboratory informatics to avoid common pitfalls

Readership

Pathology residents, pathologists, clinical chemists, microbiologists, hematologists, transfusion medicine practitioners, supervisors in point of care testing

Table of contents

Part I: Sources of errors in clinical laboratories and how to eliminate such errors?

1 Variation, errors, and quality in the clinical laboratory
Jorge Sepulveda

2 Errors in patient preparation, specimen collection, anticoagulant and preservative use: How to avoid such pre-analytical errors.
Sudip Kumar Datta

3 Sample processing and specimen misidentification issues: Major sources of pre-analytical error
Joe Wiencek, Amy L. Pyle-Eilola

4 Patient-Related Factors Influencing Clinical Laboratory Test Results and Interpretation
Octavia M. Peck Palmer

5 Interferences of hemolysis, lipemia and high bilirubin on Laboratory Tests
Anshika Chauhan, Arnab Pal

6 Immunoassay design
Pradip Datta

7 Overview of other sources of interferences in immunoassays: Prozone effect and interferences from heterophilic antibodies and autoantibodies
Pradip Datta

8 Biotin interference in clinical laboratory tests: New Solutions to an Evolving Problem
Christina Trambas

Part II: Sources of errors in clinical chemistry laboratory

9 Challenges in Routine Clinical Chemistry Testing: Analysis of Small Molecules
Jorge Sepulveda

10 Challenges in Routine Clinical Chemistry Analysis of Proteins and Enzymes
Jorge Sepulveda

11 Challenges in endocrinology testing
William E. Winter, Laura M. Jacobsen, Lindsay A. L. Bazydlo, Neil S. Harris

12 Pitfalls in Testing for Common Tumor Markers
Qing H. Meng, Stefan Holdenrieder

Part III: Sources of errors in therapeutic drug monitoring and toxicology

13 Issues of Interferences in Therapeutic Drug Monitoring
M. Chinonye Udechukwu, Vrajesh Pandya

14 Limitations of immunoassays for screening of drugs of abuse in urine due to issues of interferences (cross-reactivities) : a new interpretive paradigm
Cristiana Stefan

15 Confirmation of Immunoassay Drug Screens: From Structural Similarity to Molecular Identity
Cristiana Stefan

16 Issues of False Negative Results in Toxicology: Difficult in Detecting Certain Drugs and Issues with Detection of Synthetic Cathinone (Bath Salts), Synthetic Cathinone (Spice), and Other New Psychoactive Substances
Anthony Costantino

17 Alcohol testing in the clinical laboratory: considerations for optimal use.
Anastasia Gant Kanegusuku

Part IV: Herbal medicines and laboratory testings

18 Effects of Herbal Supplements on Clinical Laboratory Test Results
Amitava Dasgupta, Ph.D.

Part V: Sources of errors in immunology laboratory

19 Critical Issues in Hemoglobin Variant Testing
Dennis Sosnovske, Hanan S. Elsarraj

20 Sources of errors in immunology and serology testing
Alex Rai, Ph.D

Part VI: Sources of errors in molecular, genetic and related testing

21 Sources of Error in Molecular Diagnostic Analyses
Susan J. Hsiao, Ann Moyer

22 Molecular Testing for Targeted Therapies and Pharmacogenomics
Ann Moyer

23 Challenges and Sources of Inaccuracy in Biochemical Genetics Testing
Uttam Garg

Part VII: Sources of errors in microbiology testing

24 Sources of pre-analytical, analytical and post-analytical errors in the clinical microbiology laboratory
Julia Hankins

25 Accuracy Considerations in Molecular Microbiology: Sources of Errors
Robert Hamilton-Seth

26 Microbiology and the Health System at Large: Best Practices for Effective Use of Results
Julia Hankins, Robert Hamilton-Seth

Part VIII: Sources of errors in hematology and coagulation testing

27 Sources of Errors in Hematology Testing
Mark Roberts, Sandeep Gurbuxani

28 Sources of Errors in Coagulation Testing
Morayma Reyes Gil

29 Sources of errors in flow cytometry
George Vlad

Section IX: Sources of errors in blood banking and transfusion medicine

30 Interferences in Blood Typing, Compatibility Testing and Serological Testings
Shay Jones, Zhan Ye

31 Molecular testing in transfusion medicine
Keenan Hogan

32 Errors in Transfusion Medicine and Transfusion Reactions
Dennis Sosnovske

Part X: Sources of errors in point of care testing

33 Methodological issues in point of care testing devices
Kristine Zinn, Melody Nelson

34 Special Concern: Sources of Inaccuracy in Breath Alcohol Analysis
Amitava Dasgupta

Part XI: Informatics

35 Avoiding common pitfalls in clinical laboratory informatics
Melody Nelson

Product details

  • Edition: 3
  • Latest edition
  • Published: May 1, 2027
  • Language: English

About the editors

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Amitava Dasgupta

Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.

Affiliations and expertise
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA

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Jorge L. Sepulveda

Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.
Affiliations and expertise
Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA