Accurate Results in the Clinical Laboratory
A Guide to Error Detection and Correction
- 3rd Edition - May 1, 2027
- Latest edition
- Editors: Amitava Dasgupta, Jorge L. Sepulveda
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 4 0 6 6 5 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 4 0 6 6 6 - 9
Accurate Results in the Clinical Laboratory, 3rd Edition continues to be an in-depth resource of common sources of errors in clinical laboratories. It provides strategies to avoid… Read more
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Accurate Results in the Clinical Laboratory, 3rd Edition continues to be an in-depth resource of common sources of errors in clinical laboratories. It provides strategies to avoid pre-analytical errors, including patient preparation, specimen collection, and anticoagulant use and Insights into major sources of pre-analytical errors such as sample processing and specimen misidentification. This book is an essential reference for professionals and students aiming to enhance accuracy and reliability in clinical laboratory testing. This new edition has fully updated chapters and new information on how to eliminate lab errors including avoiding post analytic phase of reporting results through laboratory informatics system. This is a guide for laboratory professionals and clinicians regarding sources of errors and misinterpretation in the clinical laboratory and how to resolve such errors and identify discordant specimens. Accurate laboratory result interpretation is essential for patient safety. This book is intended as a practical guide to laboratory professionals and clinicians who deal with erroneous results on a regular basis.
• Includes detailed discussions on immunoassay design and interferences, including the prozone effect and biotin interference
• Covers modern challenges in routine clinical chemistry testing for small molecules, proteins, enzymes, endocrinology, and tumor markers
• Provides best practices in clinical laboratory informatics to avoid common pitfalls
• Covers modern challenges in routine clinical chemistry testing for small molecules, proteins, enzymes, endocrinology, and tumor markers
• Provides best practices in clinical laboratory informatics to avoid common pitfalls
Pathology residents, pathologists, clinical chemists, microbiologists, hematologists, transfusion medicine practitioners, supervisors in point of care testing
1. Sources of errors in clinical laboratories: an overview
2. Errors in patient preparation, specimen collection, anticoagulant and preservative use: How to avoid such pre-analytical errors.
3. Sample processing and specimen misidentification issues: Major sources of pre-analytical errors
4. Effect of Patient-Related Factors on Clinical Laboratory Test Results
5. Interferences of hemolysis, lipemia and high bilirubin on Laboratory Tests
6. Immunoassay design
7. Overview of other sources of interferences in immunoassays: Prozone effect and interferences from heterophilic antibodies and autoantibodies
8. Biotin interference in clinical laboratory tests: Sporadic problem or a serious clinical issue?
Part II: Sources of errors in clinical chemistry laboratory
9. Challenges in routine clinical chemistry testing: analysis of small molecules
10. Challenges in routine clinical chemistry testing: proteins and enzymes
11. Challenges in endocrinology testing
12. Pitfalls in Testing for Common Tumor Markers
Part III: Sources of errors in therapeutic drug monitoring and toxicology
13. Issues of Interferences in Therapeutic Drug Monitoring
14. Limitations of immunoassays for screening of drugs of abuse in urine: Issues of false positive and false negative results
15. Challenges in confirmation testing for drugs of abuse
16. Issues of False Negative Results in Toxicology: Difficult in Detecting Certain Drugs and Issues with Detection of Synthetic Cathinone (Bath Salts), Synthetic Cannabinoids (Spice), and Other New Psychoactive Substances
17. Ethanol determination using automated analyzers: limitations and pitfalls
Part IV: Herbal medicines and laboratory testings
18. Effects of Herbal Supplements on Clinical Laboratory Test Results
Part V: Sources of errors in immunology laboratory
19. Critical issues in Hemoglobinopathy Detection and Serology Testing for HIV and Hepatitis Infections.
20. Sources of errors in immunology and serology testing
Part VI: Sources of errors in molecular, genetic and related testings
21. Sources of Error in Molecular Diagnostic Analyses
22. Molecular Testing for Targeted Therapies and Pharmacogenomics
23. Challenges and Sources of Inaccuracy in Biochemical Genetics Testing
Part VII: Sources of errors in microbiology testings
24. Sources of pre-analytical, analytical and post-analytical errors in the clinical microbiology laboratory
25. Accuracy Considerations in Molecular Microbiology
26. Microbiology and the Hospital at Large: Best Practices for Effective Use of Results
Part VIII: Sources of errors in hematology and coagulation testings
27. Sources of Errors in Hematology Testing
28. Sources of errors in coagulation testing
29. Sources of errors in flow cytometry
Section IX. Sources of errors in blood banking and transfusion medicine
30. Interferences in blood typing and compatibility testing
31. Molecular testing in transfusion medicine
32. Errors in transfusion medicine and transfusion reaction
Part X: Sources of errors in point of care testing
33. Methodological issues in point of care testing devices
34. Special Concern: Sources of Inaccuracy in Breath Alcohol Analysis
Part XI Informatics
35. Avoiding common pitfalls in clinical laboratory informatics
2. Errors in patient preparation, specimen collection, anticoagulant and preservative use: How to avoid such pre-analytical errors.
3. Sample processing and specimen misidentification issues: Major sources of pre-analytical errors
4. Effect of Patient-Related Factors on Clinical Laboratory Test Results
5. Interferences of hemolysis, lipemia and high bilirubin on Laboratory Tests
6. Immunoassay design
7. Overview of other sources of interferences in immunoassays: Prozone effect and interferences from heterophilic antibodies and autoantibodies
8. Biotin interference in clinical laboratory tests: Sporadic problem or a serious clinical issue?
Part II: Sources of errors in clinical chemistry laboratory
9. Challenges in routine clinical chemistry testing: analysis of small molecules
10. Challenges in routine clinical chemistry testing: proteins and enzymes
11. Challenges in endocrinology testing
12. Pitfalls in Testing for Common Tumor Markers
Part III: Sources of errors in therapeutic drug monitoring and toxicology
13. Issues of Interferences in Therapeutic Drug Monitoring
14. Limitations of immunoassays for screening of drugs of abuse in urine: Issues of false positive and false negative results
15. Challenges in confirmation testing for drugs of abuse
16. Issues of False Negative Results in Toxicology: Difficult in Detecting Certain Drugs and Issues with Detection of Synthetic Cathinone (Bath Salts), Synthetic Cannabinoids (Spice), and Other New Psychoactive Substances
17. Ethanol determination using automated analyzers: limitations and pitfalls
Part IV: Herbal medicines and laboratory testings
18. Effects of Herbal Supplements on Clinical Laboratory Test Results
Part V: Sources of errors in immunology laboratory
19. Critical issues in Hemoglobinopathy Detection and Serology Testing for HIV and Hepatitis Infections.
20. Sources of errors in immunology and serology testing
Part VI: Sources of errors in molecular, genetic and related testings
21. Sources of Error in Molecular Diagnostic Analyses
22. Molecular Testing for Targeted Therapies and Pharmacogenomics
23. Challenges and Sources of Inaccuracy in Biochemical Genetics Testing
Part VII: Sources of errors in microbiology testings
24. Sources of pre-analytical, analytical and post-analytical errors in the clinical microbiology laboratory
25. Accuracy Considerations in Molecular Microbiology
26. Microbiology and the Hospital at Large: Best Practices for Effective Use of Results
Part VIII: Sources of errors in hematology and coagulation testings
27. Sources of Errors in Hematology Testing
28. Sources of errors in coagulation testing
29. Sources of errors in flow cytometry
Section IX. Sources of errors in blood banking and transfusion medicine
30. Interferences in blood typing and compatibility testing
31. Molecular testing in transfusion medicine
32. Errors in transfusion medicine and transfusion reaction
Part X: Sources of errors in point of care testing
33. Methodological issues in point of care testing devices
34. Special Concern: Sources of Inaccuracy in Breath Alcohol Analysis
Part XI Informatics
35. Avoiding common pitfalls in clinical laboratory informatics
- Edition: 3
- Latest edition
- Published: May 1, 2027
- Language: English
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Amitava Dasgupta
Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.
Affiliations and expertise
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, United StatesJS
Jorge L. Sepulveda
Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.
Affiliations and expertise
Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA