A Clinical Guide to Inositols

1st Edition - January 5, 2023
Imprint: Academic Press
Editors: Vittorio Unfer, Didier Dewailly
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 6 7 3 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 8 5 5 5 - 0

A growing body of research demonstrates the potential benefits of the administration of inositol isomers in the treatment of many different disorders, from reproductive to… Read more

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A growing body of research demonstrates the potential benefits of the administration of inositol isomers in the treatment of many different disorders, from reproductive to metabolic diseases.

A Clinical Guide to Inositols discusses scientific evidence of inositol-based treatments in different clinical fields to provide clinicians with a practical guide to use inositol supplementation within pathological conditions. Each chapter covers a specific disorder and describes aspects of the application of inositol in clinical practice, discussing the physio-pathologic features of the health condition and scientific evidences of the effects of inositol treatment.This book is a valuable resource to researchers and clinicians looking for a clear understanding of clinical effects of inositol supplementation and a practical guide on inositol-based treatments.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Acknowledgments
Chapter 1: Introduction to the history of inositols: A tale of scientists
Inositol: Early characterization in plants
Inositol in animals: From metabolism to its pivotal roles in signaling processes
Inositol in clinical practice: Early findings and stereoisomers
References
Chapter 2: Physiological and pathophysiological roles of inositols
Abstract
Introduction
Evolution of inositols
Activity of myo-Ins and its stereoisomers
myo-Ins-derived phospholipids
Natural sources of inositols
Inositol endogenous synthesis and catabolism
Inositol transport system
Inositols levels in plasma and tissues
Inositols: From the physiology to the pathophysiology
References
Chapter 3: Effectiveness of Myo- and d-chiro-inositol in the treatment of metabolic disorders
Abstract
Introduction
Energy homeostasis and glucose metabolism: The emerging role of inositols
Translating the pathogenetic background into a putative therapeutic role of inositols in metabolic disease
Conclusions
References
Chapter 4: Treating PCOS with inositols: Choosing the most appropriate myo- to d-chiro-inositol ratio
Abstract
Introduction: PCOS and polycystic ovaries
Mechanisms of action of inositol and its role in PCOS
Clinical and preclinical data
Conclusion
References
Chapter 5: Overcoming inositol resistance
Abstract
Introduction
Effect of inositols on glucose homeostasis in PCOS
Effect of inositols on ovarian function in PCOS
Inositol resistance
Conclusions
References
Chapter 6: Myo-inositol could restore peripheral inositol depletion induced by treatments for psychiatric and neurological conditions
Abstract
Introduction
Side effects of the pharmacological therapies: Consequences of peripheral inositol depletion
The efficacy of inositol supplementation
Effectiveness and safety of inositols: A matter of dosages and ratios
Conclusions
References
Chapter 7: The role of inositols in maternal adaptation, placental function, and regulation of fetal growth and development
Abstract
Introduction
Maternal adaptation to pregnancy
Placenta as a regulator of nutrient/waste exchange and maternal-fetal communication
Inositols in the regulation of fetal growth and development
Altered placental inositols in GDM and preeclampsia could impact fetal growth
Conclusion
References
Chapter 8: Inositol and the prevention of adverse fetal outcomes, with particular reference to neural tube defects
Abstract
Introduction
Neural tube defects (NTDs)
Types of NTD
Causes of NTDs
Primary prevention of NTDs—Folic acid (FA) supplementation
Inositol and prevention of NTDs
Counseling families at risk of NTD recurrence
Conclusions and future directions
References
Chapter 9: Inositol supplementation for preventing gestational diabetes mellitus
Abstract
Gestational diabetes mellitus (GDM) around the World: Basics and problematics
GDM-related complications
Prevention and treatment of GDM with inositol
Conclusions
References
Chapter 10: Use of myo-inositol in the treatment of PCOS symptoms in adolescents
Abstract
Prevalence and etiology
Diagnostic challenges
Clinical manifestations and consequences
Management
Conclusion
References
Chapter 11: Treatments with inositols in IVF procedures
Abstract
Introduction
Inositols in the male reproductive process
Inositols in the female reproductive process
Inositols and assisted reproduction technologies (ART)
References
Chapter 12: Supplementation with d-chiro-inositol in women
Abstract
Introduction
Inositol properties
DCI supplementation
Conclusion
References
Chapter 13: Application of myo-inositol and d-chiro-inositol in andrological issues
Abstract
Introduction
Role of myo-inositol in male fertility
Role of d-chiro-inositol in male fertility
Role of oxidative stress and antioxidant treatments
Conclusions
References
Chapter 14: Myo-inositol for subclinical hypothyroidism and potential prevention of thyroid tumors
Abstract
Acknowledgment
Introduction
Myo-inositol and hypothyroidism
Myo-inositol and subclinical hypothyroidism in pregnancy
Myo-inositol in thyroid tumorigenesis
Conclusions
References
Chapter 15: Inositols as adjuvant treatments in oncology
Abstract
Introduction (how it all began)
Epidemiological clues
Inositol and cancer: Basic mechanisms
Antioxidant effects
Modulation of immune system
Inositol hexakisphosphate (InsP6): The cumulated evidence
Inositol and cancer types
Chemopreventive and therapeutic efficacy of InsP6 in animal studies
Clinical trials on inositol in human cancers
Perspectives and outstanding issues
Conclusions
References
Index

Vittorio Unfer

Vittorio Unfer, MD, is a Professor at the Faculty of Medicine of the University of Modena and Reggio Emilia, Italy, and also works as an Obstetrics and Gynecology specialist, researcher and university lecturer. His research interests include aspects of nutrition and use of food supplements in obstetrics and gynecology clinical practice and the morphofunctional study of uterine contractile activity with previous uterine scar, the triggering mechanisms of labor, the treatment of the threatened miscarriage abortion and prevention of preterm labor in high-risk patients, the treatment of hypogonadotropic male hypogonadism with FSH, and several in-depth and comparative experimentations on the fetal maturity. Prof. Unfer was one of the first researchers studying the use of myo-inositol in the treatment for polycystic ovary syndrome; his in-depth research pointed out the beneficial effects of the myo-inositol molecule on ovarian function and metabolic parameters. He has published numerous articles in reputed journals, including Fertility and Sterility and International Journal of Molecular Sciences.

Affiliations and expertise

Professor, University of Modena and Reggio Emilia, Italy

Didier Dewailly

Dr Didier Dewailly is professor of Endocrinology and Reproductive Medicine in the Lille University Hospital, France. Until 2017, he was head of the Department of Endocrine Gynecology and Reproductive Medicine at the Hôpital Jeanne de Flandre, including an IVF unit. He is now retired from the Hospital, but he still keeps an academic position and coordinates the teaching of Medical Gynecology and Reproductive Medicine for the North-West area of France. He is redactor-in-chief of Médecine-Thérapeutique/Médecine de la Reproduction which is the journal of the French Reproductive Medicine Society whom he is past-President. His main fields of interest in research currently are the female hyperandrogenism (Polycystic Ovary Syndrome (PCOS) and other causes) and Ovulation Disorders such as PCOS, hypothalamic amenorrhea, hypogonadotropic hypogonadism and premature ovarian failure.

Affiliations and expertise

Professor, Endocrinology, Reproductive Medicine, Lille University Hospital, France

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health