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Books in Biochemical engineering

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Sterilisation of Tissues Using Ionising Radiations

  • 1st Edition
  • May 6, 2005
  • J F Kennedy + 2 more
  • English
  • eBook
    9 7 8 - 1 - 8 4 5 6 9 - 0 7 7 - 9
Existing methods and processing for sterilising tissues are proving inadequate in many instances. Infections have been transmitted from the graft to the recipient and in the USA the Centre for Disease Control and other regulatory bodies have drawn attention to the need for a reliable end sterilisation method which does not damage the functionality of the final tissue. Safety of surgical allografts is, therefore, a major concern due to microbial and viral contamination of tissues which is now a problem even in the most sophisticated centres.The Presidents of the main Professional Association of Tissue Banks; American, European and Latin American met in Vienna to review the situation and concluded that the time was opportune to organise an international high level expert meeting, which would identify the best method of using radiation technology to assist in the production of safe tissue allograftsSterilisation of biological tissues with ionising radiations provides the information on this subject presented at an international meeting in Wales, supported by the International Atomic Energy Agency. New methods of protecting the tissues were presented which at the same time allow the use of sufficiently high doses of ionising radiations to inactivate invading organisms. A Code of Practice for the Radiation Sterilisation of Tissues was evaluated and the outcome and the full Code is included in this volume, as well as explorations of all of the methodologies used in the field.Sterilisation of biological tissues with ionising radiations is the only volume of its kind and as such is an invaluable source of information for those working in tissue banks, transplant surgeons and the safety regulators.

Handbook of Bioseparations

  • 1st Edition
  • Volume 2
  • June 23, 2000
  • Satinder Ahuja
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 0 7 7 9 - 8
It is generally recognized that the commercial success of biotechnology products is highly dependent on the successful development and application of high-powered separation and purification methods. In this practical and authoritative handbook, the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also included in a chapter on the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography are covered at length. Regulatory and economic considerations are addressed, as are plant and process equipment and engineering process control. A chapter on future developments highlights the application of DNA chip arrays as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer's disease. Handbook of Bioseparations serves as an essential reference and guidebook for separation scientists working in the pharmaceutical and biotechnology industries, academia, and government laboratories.

Microbiological Analysis of Food and Water

  • 1st Edition
  • April 22, 1998
  • N.F. Lightfoot + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 6 5 1 - 4
With the help of leading Quality Assurance (QA) and Quality Control (QC) microbiology specialists in Europe, a complete set of guidelines on how to start and implement a quality system in a microbiological laboratory has been prepared, supported by the European Commission through the Measurement and Testing Programme. The working group included food and water microbiologists from various testing laboratories, universities and industry, as well as statisticians and QA and QC specialists in chemistry.This book contains the outcome of their work. It has been written with the express objective of using simple but accurate wording so as to be accessible to all microbiology laboratory staff. To facilitate reading, the more specialized items, in particular some statistical treatments, have been added as an annex to the book. All QA and QC tools mentioned within these guidelines have been developed and applied by the authors in their own laboratories. All aspects dealing with reference materials and interlaboratory studies have been taken in a large part from the projects conducted within the BCR and Measurement and Testing Programmes of the European Commission.With so many different quality control procedures, their introduction in a laboratory would appear to be a formidable task. The authors recognize that each laboratory manager will choose the most appropriate procedures, depending on the type and size of the laboratory in question. Accreditation bodies will not expect the introduction of all measures, only those that are appropriate for a particular laboratory.Features of this book:• Gives all quality assurance and control measures to be taken, from sampling to expression of results• Provides practical aspects of quality control to be applied both for the analyst and top management• Describes the use of reference materials for statistical control of methods and use of certified reference materials (including statistical tools).

Frontiers in Tissue Engineering

  • 1st Edition
  • February 20, 1998
  • C.W. Patrick + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 2 0 5 - 9
Frontiers in Tissue Engineering is a carefully edited compilation of state-of-the-art contributions from an international authorship of experts in the diverse subjects that make up tissue engineering. A broad representation of the medical, scientific, industrial and regulatory community is detailed in the book. The work is an authoritative and comprehensive reference source for scientists and clinicians working in this emerging field.The book is divided into three parts: fundamentals and methods of tissue engineering, tissue engineering applied to specialised tissues, and tissue engineering applied to organs. The text offers many novel approaches, including a detailed coverage of cell-tissue interactions at cellular and molecular levels; cell-tissue surface, biochemical, and mechanical environments; biomaterials; engineering design; tissue-organ function; new approaches to tissue-organ regeneration and replacement of function; ethical considerations of tissue engineering; and government regulation of tissue-engineered products.

NMR Spectroscopy and its Application to Biomedical Research

  • 1st Edition
  • December 4, 1996
  • S.K. Sarkar
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 7 5 9 - 7
NMR has become the most diverse spectroscopic tool available to date in biomedical research. It is now routinely used to study biomolecular structure and dynamics particularly as a result of recent developments of a cascade of highly sophisticated multidimensional NMR pulse sequences, and of advances in genetic engineering to produce biomolecules, uniformly or selectively enriched with 13C, 15N and 2H.Features of this book:• Provides an up-to-date treatment of NMR techniques and their application to problems of biomedical interest• Most refined multidimensional pulse sequences including the basic aspects are covered by leading NMR spectroscopists.The book will be useful to NMR spectroscopists, biochemists, and to molecular biologists interested in the use of NMR techniques for solving biological problems.

Modeling and Optimization of Fermentation Processes

  • 1st Edition
  • Volume 1
  • April 24, 1992
  • Bohumil Volesky + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 8 9 5 8 8 - 2
The ability to predict the behavior of fermentation systems enhances the possibility of optimizing their performance. Mathematical equations of model systems represent a tool for this and the most recent advances in computer hardware and software have made the approach more effective than previous simplistic attempts. The current knowledge of biochemical microbial pathways and the experience in optimization of chemical reactors combined with extremely powerful and accessible computers, loaded with easy to use software and mathematical routines, are changing the way processes are being developed and operated. This book has been written for all those who work with microbial cultures, providing a useful, quick and contemporary re-education for practitioners and students alike, breaking through interdisciplinary barriers. Biologists, engineers and biochemists will benefit from the methods of microbial process description and optimization based on mathematical equations. The basic techniques of modeling the bio-system are summarized in Part I. The useful concept of mass balancing is introduced in Part II for those who are not used to this simple and very useful engineering tool. An extensive and descriptive case study of a selected fermentation bio-process in Part III elucidates further the concepts of very pragmatic mathematical modeling of bioreactor systems.The volume outlines how to simply develop mathematical models of microbial systems and demonstrates their power to: guide and minimize the experimental work; check the consistency of experimental results; predict the behavior of the bio-system and analyze biocatalytic processes; diagnose the anomalies in the microbial culture behavior and optimize the performance of bioreactors.

Environmental Biotechnology

  • 1st Edition
  • Volume 42
  • June 6, 1991
  • A. Blažej + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 7 5 0 1 - 9
The growing awareness of environmental problems provided the stimulus for this 4th International Symposium on Biotechnology, Interbiotech '90, to address many aspects of the relationship between biotechnology and the environment. The papers are mainly devoted to the contribution of biotechnology in solving environmental problems, including biological waste water treatment, utilization of municipal sewage sludge, detoxification of polluted soil and complex utilization of lignocellulosic wastes. There is examination of possible dangers in such cases as the release of r-DNA organisms into the environment. The relationship of biotechnology and energy (e.g. biogas, landfill gas fuel, photosynthetic systems for fuel production) is also discussed.