Chitosan-Based Hybrid Nanomaterials focuses on chitosan, an abundantly occurring biopolymer, to present possibilities for the removal of contaminants and a greener approach towards a cleaner environment – combining nanotechnology with the deployment of naturally occurring materials to remedy environmental challenges. This book fills research gaps and what is known about chitosan-based nanomaterials. Considering the importance of naturally occurring materials with the applied knowledge of nanotechnology in the field of environmental restoration, this book is an ideal resource for interested parties and career professionals.
RNA Therapeutics, Part B, Volume 204 updates on a new class of medication based on RNA molecules, with chapters on a variety of topics, including RNA therapeutics for cardiovascular disorders, RNA therapeutics for kidney injury, RNA therapeutics for beta-thalassemia, RNA therapeutics for infectious diseases, RNA therapeutics for reproductive diseases, Potential of RNA and transcriptomic data to drive drug repurposing for various diseases, RNA therapeutics for glioma/glioblastoma, RNA therapeutics for regenerative medicine, Advances in the liposome-based delivery systems for RNA therapeutics in cancer, Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics in cancer, and more.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants.
Cell-based Cancer Immunotherapy, Volume 183 provides the latest progress concerning research on anticancer cellular immunotherapies and their immunological, translation, or clinical aspects. Topics covered in this volume include Methods behind clinical DC vaccine products against glioblastoma, Fully closed and automated isolation of natural blood dendritic cells for cancer immunotherapy, Methods behind Oncolytic virus-based DC vaccines in cancer: towards a multiphase combined treatment strategy for Glioblastoma (GBM) patients, Identification of TCR repertoire patterns linked with anti-cancer immunotherapy, Training of epitope-TCR prediction models with healthy donor-derived cancer-specific T cells, Methods behind neoantigen predictions for anticancer vaccines, Methods behind CD137L-DC-EBV-VAX anticancer vaccine, and much more. Additional sections cover Gold Standard Assessment of Immunogenic Cell Death Induced by Photodynamic Therapy: From In Vitro to Tumor Mouse Models and Anti-Cancer Vaccination Strategies, Methods behind TCR analyses for colorectal cancer-associated TILs, The use of xCELLigence, Incucyte, and/or Cr/LDH/maker-release assays, Humanized mouse models for anti-cancer therapy, In vitro re-challenge of CAR T cells, Methods behind adoptively transferred tumor draining lymphocytes for anticancer immunotherapy, and A murine glioblastoma platform to test cellular therapies with the standard of care.
Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds will be of great interest to undergraduate and graduate students, scientists, researchers, and engineers who work on the microbial production of plant-derived bioactive compounds. As many plant-derived bioactive compounds are the foundation of effective drugs to cure diseases, it's important to understand the limits of their applications in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast.This book summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing the content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks.
The Lentil Genome: Genetics, Genomics and Breeding is a comprehensive volume on this important legume, from its economic importance to the latest in sequencing. The book includes botanical descriptions, discussion of lentil genetics, cytogenetics and breeding, molecular mapping genes and QTLs, as well as structural and functional genomics, genome sequencing, assembly, repetitive genome, gene annotation and synteny. Lentil [Lens culinaris ssp. culinaris Medikus] is among the earliest domesticates from the Near-East Fertile Crescent and plays a vital role in nutritional wellbeing and livelihood for the small-scale farmers in the dryland agricultural ecosystems of South Asia, Sub-Saharan Africa, West Asia, and North Africa. The classical plant breeding approach of selection-recombination-selection has been used successfully for genetic improvement in lentil. However further genetic improvement for developing the high yielding cultivars is required knowledge of gene network underlying the complex traits. Realizing the importance of genomics enabled improvement in crop plants, the scientific community has recently placed major emphasis on whole genome sequencing in many major crops including lentil. This compilation of the latest lentil genome research serves the immediate needs of students, scientists and is needed to strengthen conventional crop improvement strategies of lentil.
Advances in Parasitology, Volume 123, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy, and life history.
Evaporation Technology in Food Processing, in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for recent invented non-thermal processing of different food products, including ozonation, plasma processing, pulsed electric fields, high pressure processing, irradiation and high frequency processing. These processes and unit operations are very important in terms of achieving favorable sensory properties and energy usage. Written by experts in the field of food engineering, this book targets industrial engineers working in the field of food processing and within food factories. The book is divided into four sections: “Evaporation basics," “Different types of evaporators,” “Application of evaporators in the food industry”, and “Design, control and efficiency of evaporators”. All chapters emphasize basic texts relating to experimental, theoretical, computational, and/or applications of food engineering principles and the relevant processing equipment to evaporation unit operations.
Strigolactones: Synthesis, Application and Role in Plants presents the current state of the science for this recently discovered class of plant hormones, offering foundational insights. The book covers the structure of natural and synthetic SLs, synthesis, transport, signaling, and their application, role in the growth and development of plants like seed germination, root growth, and stem branching plant architecture. Further, the crosstalk of SLs with other plant hormones and signaling molecules are discussed. Finally, the role of SLs in plant defense systems, particularly in biotic and abiotic stresses, heavy metals, salt, temperature, radiation, pesticide drought, and flood stress on plants.Concluding with the latest discoveries, future perspectives, and challenges in plant biology, this book will be a valuable reference for those in plant and agricultural sciences.
Aging: How Aging Works, How We Reverse Aging, and Prospects for Curing Aging Diseases explains the process of aging beyond mere entropy, exposing it as a complicated and dynamic process that undercuts maintenance and permits age-related disease. With a deeper understanding of the aging process, intervention becomes both easy to understand and clinically feasible.With a solid academic approach, this proposed book builds upon the substantial work published over the past 20 years, citing the newest data, up-to-date models based upon that data, and the implications for improved clinical intervention, including recent developments in gene and cell therapy. Coverage of age-related diseases includes neurodegenerative, cardiovascular, bone and joint, immune system, renal, pulmonary, and skin aging. Future directions of the field focus on interventions, including a summary of previous attempts to intervene in aging and age-related disease, the status of current research, and proposed biotech interventions, as well as their potential obstacles, risks, and benefits. This is the perfect reference for scientists, clinicians, and researchers interested in the translational research opportunities such as drug discovery, pharmacogenetics, and experimental therapeutics, not only summarizing where the field stands, but giving a clear and cogent view of where clinical medicine is going in the next decade.