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Books in Life sciences

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    • Inflammation and Immunity in Depression

      • 1st Edition
      • May 23, 2018
      • Bernhard Baune
      • English
      • Paperback
        9 7 8 0 1 2 8 1 1 0 7 3 7
      • eBook
        9 7 8 0 1 2 8 1 1 0 7 4 4
      Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.

    • Statistical, Mapping and Digital Approaches in Healthcare

      • 1st Edition
      • November 19, 2018
      • Gilles Maignant + 1 more
      • English
      • Hardback
        9 7 8 1 7 8 5 4 8 2 1 1 3
      • eBook
        9 7 8 0 0 8 1 0 1 9 6 2 7
      Statistical, Mapping and Digital Approaches in Healthcare addresses all health territories, starting from the analysis of geographical data (health data, population data, health data systems and environmental data), to new health areas (Health 3.0), i.e. digital health territories. Specific tools are used to question environmental changes, such as health statistics, mapping, mathematical models, optimization models and serious games.

    • A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics

      • 1st Edition
      • August 31, 2018
      • Xiao-Dong Chen
      • English
      • Paperback
        9 7 8 0 1 2 8 1 1 9 2 0 4
      • eBook
        9 7 8 0 1 2 8 1 1 9 2 1 1
      A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.

    • Balance, Gait, and Falls

      • 1st Edition
      • Volume 159
      • November 24, 2018
      • English
      Balance, Gait, and Falls, Volume 159 presents the latest information on sensorimotor anatomy, sensory integration, gravity and verticality, standing balance, balance perturbations, voluntary stepping and gait initiation, gait and gait adaptability, disorders of balance and gait that result from aging and neurological diseases. The book provides a brief overview of age-related changes in the structure and function of sensorimotor and central processes, with sections specifically devoted to Parkinson’s disease, parkinsonism, cerebellar ataxia, stroke, corticobasal degeneration, multiple sclerosis, Huntington’s disease, dystonia, tremor, Alzheimer’s disease, frontotemporal dementia, cerebral palsy, polio, motor neuron disease, brainstem lesions, spinal lesions, peripheral nerve disease, and psychogenic conditions. Diseases covered have a common structure comprising background and epidemiology, pathology, balance disorders, gait disorders, falls, therapies (including fall prevention), and future directions.

    • Bipolar Disorder Vulnerability

      • 1st Edition
      • June 9, 2018
      • Jair Soares + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 2 3 4 7 8
      • eBook
        9 7 8 0 1 2 8 1 2 5 6 0 1
      Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness.

    • Gene Therapy in Neurological Disorders

      • 1st Edition
      • May 25, 2018
      • Mingjie Li + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 9 8 1 3 4
      • eBook
        9 7 8 0 1 2 8 0 9 8 2 1 9
      Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system.

    • Pharmacoepidemiology and Pharmacovigilance

      • 1st Edition
      • October 17, 2018
      • Sabrina Nour + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 6 1 8 3 8
      • eBook
        9 7 8 0 1 2 8 1 6 3 8 1 8
      Pharmacoepidemiology and Pharmacovigilance: Synergistic Tools to Better Investigate Drug Safety examines the role of pharmacoepidemiologi... studies in drug development and its use as a prevention tool in pharmacovigilance activities. The book introduces the various epidemiologic tools and study designs commonly used for the surveillance of drug-related adverse effects and reviews the strengths and weaknesses of each. Criticisms surrounding pharmacoepidemiologi... research and issues that often interfere or complicate the conduct and interpretation of these studies are also explored. Case studies illustrate the passive and active surveillance of adverse drug reactions in clinical situations, covering important pharmacoepidemiologi... concepts like health risk management and safety. The book helps pharmaceutical industry groups engaged in drug safety, clinical investigators, medical evaluators and those seeking regulatory approval enhance the safety of the drug development process for all patient populations.

    • Biology and Ecology of Venomous Marine Scorpionfishes

      • 1st Edition
      • September 25, 2018
      • Ramsamy Santhanam
      • English
      • Paperback
        9 7 8 0 1 2 8 1 5 4 7 5 5
      • eBook
        9 7 8 0 1 2 8 1 5 8 3 4 0
      Biology and Ecology of Venomous Marine Scorpionfishes examines the diversity, utilization, and ways to safeguard against the world’s most dangerous fish species. It covers the biological and ecological factors that differentiate each species in the Scorpaeninae (Scorpionfish) family and its Pteroinae (Lionfish) subfamily. This book offers important anatomical and identification information on marine scorpionfishes and delves into the diversity, habits and behaviors of each venomous species. In addition, it discusses the health risks that can plague these fish in and out of the wild, including parasites. This book is an essential resource to educate marine biology researchers and students on the various species of scorpionfish that also provides sea-goers with a guide that will help protect them against venomous stings from these fish.

    • Surgery in Rheumatic and Musculoskeletal Disease

      • 1st Edition
      • Volume 15
      • March 26, 2018
      • Fabiola Atzeni + 4 more
      • English
      • Hardback
        9 7 8 0 4 4 4 6 3 8 8 7 8
      • eBook
        9 7 8 0 4 4 4 6 3 8 8 8 5
      Surgery in Systemic Autoimmune Disease, Volume 15, describes the state-of-the-art of the use of surgery in treating the most common systemic autoimmune diseases (SADS). The volume consists of an introductory chapter concerning the impact of surgery on SADs, follow by eight chapters describing the use of surgery in the treatment of specific diseases in various areas (cardiology, gastroenterology, orthopedics, neurology. etc.) and the possible difficulties and complications. The final five chapters deal with the possible complications arising during the course of biological and non-biological treatment, also providing recommendation concerning their management. International in scope, the list of more than 20 contributors from Europa and America reads like a who’s who of clinical researchers in the field.

    • Advances in Immunology

      • 1st Edition
      • Volume 139
      • September 21, 2018
      • Frederick Alt
      • English
      • Hardback
        9 7 8 0 1 2 8 1 5 1 8 7 7
      • eBook
        9 7 8 0 1 2 8 1 5 5 2 8 8
      Advances in Immunology, Volume 139, the latest issue of a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including chapters on Alzheimer's and its innate receptors, the field of immune orchestration by small molecules, like chemokines and lipids, the role of AID in the first checkpoint, and the design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies.

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