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4291-4300 of 14737 results in All results

Gangliosides in Health and Disease

  • 1st Edition
  • Volume 156
  • April 25, 2018
  • Ronald L Schnaar + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 1 2 3 4 1 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 3 4 2 - 3
Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field.

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research

  • 1st Edition
  • April 24, 2018
  • Robert T. Gerlai
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 4 0 7 8 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 4 1 1 6 - 1
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

Multivariate Analysis in the Pharmaceutical Industry

  • 1st Edition
  • April 24, 2018
  • Ana Patricia Ferreira + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 1 0 6 5 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 1 0 6 6 - 9
Multivariate Analysis in the Pharmaceutical Industry provides industry practitioners with guidance on multivariate data methods and their applications over the lifecycle of a pharmaceutical product, from process development, to routine manufacturing, focusing on the challenges specific to each step. It includes an overview of regulatory guidance specific to the use of these methods, along with perspectives on the applications of these methods that allow for testing, monitoring and controlling products and processes. The book seeks to put multivariate analysis into a pharmaceutical context for the benefit of pharmaceutical practitioners, potential practitioners, managers and regulators. Users will find a resources that addresses an unmet need on how pharmaceutical industry professionals can extract value from data that is routinely collected on products and processes, especially as these techniques become more widely used, and ultimately, expected by regulators.

Developmental Biology and Musculoskeletal Tissue Engineering

  • 1st Edition
  • April 24, 2018
  • Martin J. Stoddart + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 1 4 6 7 - 4
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 1 5 3 8 - 1
Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells.

Immunology in the Twentieth Century

  • 1st Edition
  • April 24, 2018
  • Domenico Ribatti
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 6 1 4 5 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 6 1 4 6 - 3
Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the defense against pathogens. The subject has grown in importance and diversified into specialist fields, such as immunohistochemistry, immunogenetics and immunopathology.

Biomechanics of the Spine

  • 1st Edition
  • April 23, 2018
  • Fabio Galbusera + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 2 8 5 1 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 8 5 2 - 7
Biomechanics of the Spine encompasses the basics of spine biomechanics, spinal tissues, spinal disorders and treatment methods. Organized into four parts, the first chapters explore the functional anatomy of the spine, with special emphasis on aspects which are biomechanically relevant and quite often neglected in clinical literature. The second part describes the mechanics of the individual spinal tissues, along with commonly used testing set-ups and the constitutive models used to represent them in mathematical studies. The third part covers in detail the current methods which are used in spine research: experimental testing, numerical simulation and in vivo studies (imaging and motion analysis). The last part covers the biomechanical aspects of spinal pathologies and their surgical treatment. This valuable reference is ideal for bioengineers who are involved in spine biomechanics, and spinal surgeons who are looking to broaden their biomechanical knowledge base. The contributors to this book are from the leading institutions in the world that are researching spine biomechanics.

Keys to Running Successful Research Projects

  • 1st Edition
  • April 23, 2018
  • Katherine Christian
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 3 1 3 4 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 1 3 5 - 0
Keys to Running Successful Research Projects: All the Things They Never Teach You provides a step-by-step guide for the management of a successful research project or program. Through the use of illustrative case studies, the book covers all aspects of management that should be included during researcher training, helping researchers overcome the many challenges they face in their day-to-day management of people, time and resources. Links throughout provide more detailed information from gold standard sources on every topic. It is a must-have reference for postdocs, research managers and administrators in colleges, universities, hospitals and research institutes. In addition, it is an ideal resource for those working in grant and contract funding groups in the life sciences and medical fields.

G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation Part A

  • 1st Edition
  • Volume 338
  • April 23, 2018
  • Arun K. Shukla
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 1 3 7 7 2 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 7 7 3 - 4
G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation, Part A, Volume 337 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This new release includes comprehensive sections on the classical paradigms of GCPR signaling and regulation, the family of small GTPases: Beyond heterotrimeric G proteins, GPCR endocytosis: Arrestins, arrestin-like proteins, signaling from internalized G Protein-Coupled Receptors, GPCR kinases, and more.

Ranunculales Medicinal Plants

  • 1st Edition
  • April 23, 2018
  • Da-Cheng Hao
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 4 2 3 2 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 4 2 3 3 - 2
Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource.

The Auditory System in Sleep

  • 2nd Edition
  • April 20, 2018
  • Ricardo Velluti
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 0 4 7 6 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 0 4 7 8 - 1
The Auditory System in Sleep, Second Edition presents a view of a sensory system working in a different state, that of the sleeping brain. This updated edition contains new chapters on topics such as implanted deaf patients and sleep and tinnitus treatments. It is written for basic auditory system and sleep researchers, as well as practitioners and clinicians in the Auditory/Sensory Neurosciences and Sleep Medicine. As the auditory system is always “open”, thus receiving information from the environment and the body itself (conscious and unconscious data), the incoming sensory information may alter sleep and waking physiology, and conversely, the sleeping brain. This book draws information from evoked potentials, fMRI, PET, SPECT, lesions, and more.

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