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Books in Life sciences

  • Tumor Microenvironment Regulation of Tumor Expansion

    • 1st Edition
    • April 4, 2021
    • Domenico Ribatti
    • English
    Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.

  • Cellular Networks in Development

    • 1st Edition
    • Volume 143
    • April 2, 2021
    • English
    Current Topics in Developmental Biology, Volume 143, the latest release in this acclaimed series, highlights new advances in the field, with this new volume presenting new sections on Building a ciliated epithelium: Transcriptional regulation and radial intercalation of multiciliated cells, Biomechanics of Amphibian Morphogenesis, Planar cell polarity during neural tube closure, Left-right asymmetry research in Xenopus: Questions solved and new frontiers, Xenopus neural crest and its relevance to human disease, Endoderm organogenesis, From egg to embryo in marsupial frogs, Evo-devo lessons from the analysis of Xenopus genomes, Transcriptional regulation during zygotic genome activation, and much more.

  • Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations Part 2

    • 1st Edition
    • Volume 33
    • April 1, 2021
    • English
    Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations, Part Two, Volume 33 in the Advances in Biomembranes and Lipid Self-Assembly series, highlights new advances in the field, with sections in this new release covering Biomembranes of extracellular vesicles: The protein component, Protocol for isolation of Microvesicles form blood plasma, Urinary Extracellular vesicles at single patient level for clinical research, Treatment of chronic wounds with platelet and extracellular vesicles enriched plasma, Liposome loading and imaging, The Potential of Extracellular Vesicles for Brain Repair, Nucleic acids cargo of extracellular vesicles: Analysis and physiological function, Propolis flavonoids and terpenes, and much more.

  • Reciprocal Translation Between Pathophysiology and Practice in Health and Disease

    • 1st Edition
    • April 1, 2021
    • Peter B. Soeters + 1 more
    • English
    Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses.With contributions from Petronella L.M. Reijven.

  • Recent Advances in iPSC Technology

    • 1st Edition
    • March 31, 2021
    • Alexander Birbrair
    • English
    The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies.Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more.The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

  • Rational Machines and Artificial Intelligence

    • 1st Edition
    • March 31, 2021
    • Tshilidzi Marwala
    • English
    Intelligent machines are populating our social, economic and political spaces. These intelligent machines are powered by Artificial Intelligence technologies such as deep learning. They are used in decision making. One element of decision making is the issue of rationality. Regulations such as the General Data Protection Regulation (GDPR) require that decisions that are made by these intelligent machines are explainable. Rational Machines and Artificial Intelligence proposes that explainable decisions are good but the explanation must be rational to prevent these decisions from being challenged. Noted author Tshilidzi Marwala studies the concept of machine rationality and compares this to the rationality bounds prescribed by Nobel Laureate Herbert Simon and rationality bounds derived from the work of Nobel Laureates Richard Thaler and Daniel Kahneman. Rational Machines and Artificial Intelligence describes why machine rationality is flexibly bounded due to advances in technology. This effectively means that optimally designed machines are more rational than human beings. Readers will also learn whether machine rationality can be quantified and identify how this can be achieved. Furthermore, the author discusses whether machine rationality is subjective. Finally, the author examines whether a population of intelligent machines collectively make more rational decisions than individual machines. Examples in biomedical engineering, social sciences and the financial sectors are used to illustrate these concepts.

  • Handbook of Decision Support Systems for Neurological Disorders

    • 1st Edition
    • March 30, 2021
    • D. Jude Hemanth
    • English
    Handbook of Decision Support Systems for Neurological Disorders provides readers with complete coverage of advanced computer-aided diagnosis systems for neurological disorders. While computer-aided decision support systems for different medical imaging modalities are available, this is the first book to solely concentrate on decision support systems for neurological disorders. Due to the increase in the prevalence of diseases such as Alzheimer, Parkinson’s and Dementia, this book will have significant importance in the medical field. Topics discussed include recent computational approaches, different types of neurological disorders, deep convolution neural networks, generative adversarial networks, auto encoders, recurrent neural networks, and modified/hybrid artificial neural networks.

  • Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A

    • 1st Edition
    • Volume 179
    • March 28, 2021
    • English
    Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics.

  • What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology

    • 1st Edition
    • Volume 158
    • March 28, 2021
    • English
    What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more. Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal’s decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.

  • Web Semantics

    Cutting Edge and Future Directions in Healthcare
    • 1st Edition
    • March 27, 2021
    • Sarika Jain + 2 more
    • English
    Web Semantics strengthen the description of web resources to exploit them better and make them more meaningful for both humans and machines, thereby contributing to the development of a knowledgeintensive data web. The world is experiencing the movement of concept from data to knowledge and the movement of web from document model to data model. The underlying idea is making the data machine understandable and processable. In the light of these trends, conciliation of Semantic and the Web is of paramount importance for further progress in the area. Web Semantics: Cutting Edge and Future Directions in Healthcare describes the three major components of the study of Semantic Web, namely Representation, Reasoning, and Security with a special focus on the healthcare domain. This book summarizes the trends and current research advances in web semantics, emphasizing the existing tools and techniques, methodologies, and research solutions. It provides easily comprehensible information on Web Semantics including semantics for data and semantics for services.

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