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Books in Drug design

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31-40 of 52 results in All results

Profiles of Drug Substances, Excipients and Related Methodology

  • 1st Edition
  • Volume 41
  • February 26, 2016
  • Harry G. Brittain
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 4 7 8 4 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 5 1 7 6 - 4
Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

Drug-Like Properties

  • 2nd Edition
  • December 17, 2015
  • Li Di + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 1 0 7 6 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 3 2 2 - 9
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

Essential Chemistry for Formulators of Semisolid and Liquid Dosages

  • 1st Edition
  • October 15, 2015
  • Vitthal S. Kulkarni + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 1 0 2 4 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 0 7 2 - 3
A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosity, microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations.

Artificial Neural Network for Drug Design, Delivery and Disposition

  • 1st Edition
  • October 15, 2015
  • Munish Puri + 4 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 1 5 5 9 - 9
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 7 4 4 - 9
Artificial Neural Network for Drug Design, Delivery and Disposition provides an in-depth look at the use of artificial neural networks (ANN) in pharmaceutical research. With its ability to learn and self-correct in a highly complex environment, this predictive tool has tremendous potential to help researchers more effectively design, develop, and deliver successful drugs. This book illustrates how to use ANN methodologies and models with the intent to treat diseases like breast cancer, cardiac disease, and more. It contains the latest cutting-edge research, an analysis of the benefits of ANN, and relevant industry examples. As such, this book is an essential resource for academic and industry researchers across the pharmaceutical and biomedical sciences.

A Practical Guide to Rational Drug Design

  • 1st Edition
  • October 1, 2015
  • Sun Hongmao
  • English
  • Hardback
    9 7 8 - 0 - 0 8 - 1 0 0 0 9 8 - 4
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 0 1 0 5 - 9
This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors’ active compounds or from natural ligands of the targets; how to springboard from competitors’ SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.

Prodrug Design

  • 1st Edition
  • July 7, 2015
  • Vivekkumar K Redasani + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 3 5 1 9 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 5 5 7 - 3
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference.

Drug Design and Discovery in Alzheimer’s Disease

  • 1st Edition
  • June 2, 2015
  • Atta-ur Rahman + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 3 9 5 9 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 9 6 0 - 1
Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of β-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

Basic Principles of Drug Discovery and Development

  • 1st Edition
  • April 24, 2015
  • Benjamin E. Blass
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 4 1 1 5 2 5 - 5
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment

  • 1st Edition
  • March 3, 2015
  • Kunal Roy + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 1 5 0 5 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 6 3 3 - 6
Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment describes the historical evolution of quantitative structure-activity relationship (QSAR) approaches and their fundamental principles. This book includes clear, introductory coverage of the statistical methods applied in QSAR and new QSAR techniques, such as HQSAR and G-QSAR. Containing real-world examples that illustrate important methodologies, this book identifies QSAR as a valuable tool for many different applications, including drug discovery, predictive toxicology and risk assessment. Written in a straightforward and engaging manner, this is the ideal resource for all those looking for general and practical knowledge of QSAR methods.

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

  • 1st Edition
  • December 30, 2014
  • Manmohan Singh + 1 more
  • English
  • Hardback
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  • eBook
    9 7 8 - 0 - 1 2 - 4 1 6 6 6 1 - 5
Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies.