Books in Neuroimmunology

The Brain and Host Defense

1st Edition
Volume 9
December 24, 2009
Barry G. W. Arnason + 1 more
English
Hardback
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eBook
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It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems.Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system.

The Hypothalamus-Pituitary-Adrenal Axis

1st Edition
Volume 7
July 7, 2008
Adriana Del Rey + 2 more
English
Hardback
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eBook
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The hypothalamic-pituita... axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease.

Cytokines and the Brain

1st Edition
Volume 6
May 8, 2008
Christopher P. Phelps + 1 more
English
Hardback
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eBook
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This book opens a new page of neuro-immunobiology providing substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. The volume is a collection of complex, new data drawn from multiple areas of investigation in the field. The contents summarize current understanding on the presence and function of CNS cytokines and their receptors in a variety of CNS cells during health and disease. The chapters are a collection of complex, new data demonstrating the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease. The strength of the volume are the descriptions of the authors own investigations, together with those of others in the field pertaining to a large number of cytokines in brain function, as well as mechanisms involved in the development of CNS disorders, including multiple sclerosis and Alzheimer’s disease. Also included are novel approaches to the treatment of CNS disorders based on new experimental data. The contributors to this volume are internationally known scientists and clinical researchers in their respective fields of investigation and treatment.

Psychoneuroimmunology

4th Edition
September 21, 2006
Robert Ader
English
eBook
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Psychoneuroimmunolog... is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; most chapters cover active areas of research that have not previously been reviewed. As illustrated in this fourth edition, interdisciplinary research continues to provide evidence that the brain and immune system represent a single, integrated system of defense.

Introduction to Psychoneuroimmunology

1st Edition
July 26, 2004
Jorge H. Daruna
English
eBook
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Psychoneuroimmunolog... investigates the relationships between behavior, psychosocial factors, the nervous, endocrine, and immune systems, and disease. Each system affects the others, enhancing and/or inhibiting processes elsewhere in the body. Research in this field has grown tremendously in recent years as science better understands the checks and balances of these interdisciplinary systems and processes. Introduction to Psychoneuroimmunolog... provides the first introductory text for this complex field.Beginning with a discussion of immune system basics, Introduction to Psychoneuroimmunolog... explores endocrine-immune modulation, neuro-immune modulation, the relationship between stress, contextual change, and disease, as well as infection, allergy, immune activity and psychopathology, and immune function enhancement. This text provides a sound introduction to the field and will serve as a valuable overview to what is otherwise a complex interdisciplinary subject at the junction of molecular biology, genetics, the neurosciences, immunology, cell biology, endocrinology, pharmacology, biochemistry, and the behavioral sciences.

The Immune-Neuroendocrine Circuitry

1st Edition
Volume 3
August 14, 2003
I. Berczi + 1 more
English
eBook
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The book summarises the current understanding of the Nervous -, Endocrine and Immune systems with emphasis on shared mediators and receptors and functional interaction. In addition to the fundamental physiological and pathophysiological mechanisms, which are presented in detail, some clinically relevant subjects are also presented, such as inflammation, asthma and allergy, autoimmune disease, immunodeficiency and the acute phase response. • A comprehensive presentation of neuroimmune biology• Introduces the subject matter to the uninformed reader• Contains basic information, theoretical considerations and up-to-date clinical chapters• The clinical chapters will be helpful to practising physicians

Universes in Delicate Balance: Chemokines and the Nervous System

1st Edition
April 29, 2002
R.M. Ransohoff + 4 more
English
Hardback
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eBook
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It is commonly acknowledged that the nervous system and the immune system, those most complex of networks, share attributes beyond their intricacy. Elements common to the two systems include memory, connectivity, flexibility and developmental selection of cellular composition by a rigorous process involving widespread programmed cell death. There is one salient difference: the cells of the immune system are predominantly in constant motion, while post-mitotic neurons and glia are largely fixed in place. Therefore, chemokines, initially characterized as leukocyte chemoattractants, have for the last one and one-half decades been intensely and productively studied in the contexts of inflammation, immunity and hematopoietic development.Only recently have the two fields, neurobiology and immunology, displayed mutual interests in chemokines. This convergence of the two tribes of investigators was catalyzed by the finding that SDF-1 (now known as CXCL12) and its receptor, CXCR4, exerted significant and similar functions in development of both nervous and immune systems. Indeed CXCL12 and CXCR4 were required, in an uncannily similar fashion, for retention of pre-B lymphocytes at sites of maturation in the bone marrow and of neuronal progenitors in the external granule cell layer of the developing cerebellum. Recent reports indicate that chemoattraction of cerebellar granule cells through CXCR4 can be suppressed by reverse signaling initiated by binding of soluble eph receptors to transmembrane ephrin B, thereby establishing a link between chemokine action and a cardinal patterning system of the developing nervous system. As may be anticipated when a dam breaks, a massive influx of correlative observations in the nervous and immune systems is likely to ensue.This volume represents the state of current knowledge. To this end, introductory material for both systems is provided. Basic and advanced 'chemokinology' are presented. The recipe for making a nervous system (both ingredients and instructions for preparation) is described, as are the roles of chemokines and their receptors in making an immune system. Given their importance and complexity, CXCL12/CXCR4 interactions are separately treated in varying contexts.The field of 'neurobiology of chemokines' has not lain fallow during the last ten years. During much of this time the principal focus has been on neuroinflammation. Linking the immune and nervous systems are explanations of the functions of chemokines and their receptors for resident brain macrophages, the microglia, the unique cerebrovascular endothelium and angiogenesis.Underst... human disease is the goal of much of this research. New discoveries are being made and reported at a gratifying rate. It is expected that this volume will promote the steady production and application of useful new knowledge in this developing field. It provides a unique single-source database for basic neurobiology highlighting the fundamental aspects of chemokines and discussing the relations of chemokine science to animal models and human disease.

Growth and Lactogenic Hormones

1st Edition
Volume 2
April 18, 2002
L. Matera + 1 more
English
eBook
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For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity.The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.

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