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Books in Molecular neuroscience

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61-68 of 68 results in All results

Cellular Imaging Techniques for Neuroscience and Beyond

  • 1st Edition
  • August 8, 2012
  • Floris G. Wouterlood
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 3 8 5 8 7 2 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 5 8 7 3 - 3
The imaging of small cellular components requires powerful instruments, and an entire family of equipment and techniques based on the confocal principle has been developed over the past 30 years. Such methods are commonly used by neuroscience researchers, but the majority of these users do not have a microscopy or a cell biology backgrounds and do can encounter difficulties in obtaining and interpreting results. This volume brings experts in high-resolution optical microscopy applications in neuroscience and cell biology together to document the state of the art. Outlining what is currently possible, the volume also discusses promising developments for the future and aids readers in selecting the most scientifically meaningful approach to solve their questions. Each chapter discusses instrumentation and technology in relationship to application in research. All of the common and cutting edge trends are covered - fluorescence / laser electron / nonlinear microscopy, infrared fluorescence, multiphoton imaging, tomography, FRAP, live imaging, STED, PALM/STORM, etc.

From Molecules to Networks

  • 1st Edition
  • November 10, 2003
  • John H. Byrne + 3 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 4 9 1 3 5 - 6
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.

Functional Neuroanatomy of the Nitric Oxide System

  • 1st Edition
  • Volume 17
  • June 30, 2000
  • H.W.M. Steinbusch + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 2 0 8 - 0
This volume of the Handbook of Neuroanatomy is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before.The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time.All these points together make this volume very timely, i.e. overviewing a decade of NO research.

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

  • 1st Edition
  • Volume 117
  • November 9, 1998
  • F.W. Van Leeuwen + 4 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 2 4 2 - 2
This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.

Molecular & Cellular Mechanisms of Neurotransmitter Release

  • 1st Edition
  • Volume 29
  • July 21, 1998
  • Lennart Stjarne + 5 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 0 3 6 1 2 9 - 8
This volume reviews recent findings on the regulation of exocytotic release of neurotransmitters from nerve terminals. Leading international investigators examine the properties and composition of the vesicles that store neurotransmitters and the molecular and cellular mechanisms that cause a vesicle to release transmitters in response to a nerve impulse.Coverage includes detailed analyses of quantal release of transmitters in the central and peripheral nervous systems. These studies shed new light on the questions of whether different transmitters are released together in fixed amounts and proportions, and whether and why effectors respond to such "transmitter quanta" in a quantal fashion. The book also highlights the relevance of research on neurotransmitter release to the study of various forms of synaptic plasticity, including higher functions such as learning and memory.

Serotonin Receptors and their Ligands

  • 1st Edition
  • Volume 27
  • July 10, 1997
  • B. Olivier + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 4 1 1 1 - 2
An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structure - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters.The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account.The (potential) therapeutic applications of ligands of the different subtypes are described.Altogether an excellent addition to the Pharmacochemical Library series.

Hypothalamic Integration of Circadian Rhythms

  • 1st Edition
  • Volume 111
  • December 3, 1996
  • R.M. Buijs + 4 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 2 3 6 - 1
The International Summer School of Brain Research, on which this book is based, was organized by the Netherlands Institute for Brain research (NIBR), which has a rich history dating back to the beginning of the century.The focus of interest in this present volume of Progress in Brain Research are the few thousand neurons at the base of the hypothalamus that form the biological clock. Attention is focused on the mechanisms underlying the generation of circadian rhythmicity within our biological clock, which is still far from understood. Contributions originating from many disciplines give updates on the latest theories on the molecular and electrophysiological basis of the pacemaker mechanism, and the various approaches used in different species. Attention is also paid to the way the signal of the biological clock is transferred to the rest of the central nervous system. New data on the role of the suprachiasmatic nucleus and its impact on the functioning of the human being is presented. Altogether an excellent volume which will further the understanding of this elusive material.

Neuroscience: From the Molecular to the Cognitive

  • 1st Edition
  • Volume 100
  • July 19, 1994
  • Floyd E. Bloom
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 2 2 5 - 5
This hundredth volume is a commemorative milestone in the prestigeous Progress in Brain Research series. Accordingly, authors were invited to write on any topic, given that their choice represented the topic most near and dear to their own efforts over a significant period of the recent past, and to which they would likely continue to be devoted in the future.In that sense, this volume does not represent a scientific meeting, but rather an overview sample of problems and methodologies that epitomize brain research broadly at this special moment in the maturation of the field.The chapters comprising this volume assort themselves readily into five or six established categories of topics: developmental brain research, molecular brain research, integrative brain research, neuroplasticity, and neuro-psychiatric conditions.This volume reports through a sample of recognized leaders in the neuroscientific community at a significant instant in the history and evolution of the field.