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Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

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Medical Microbiology: An Introduction to Infectious Diseases

  • 2nd Edition
  • J.C. Sherris
  • English
This extensively revised text has been modified in the light of new developments in the field. The major changes include a substantial increase in the depth of coverage of basic microbiology which is effectively correlated to the disease states encountered in patient care. Incorporated in this second edition are new features including chapters on basic bacteriology and virology, host defenses covering basic immunology, retroviruses, DNA tumor viruses and AIDS.Presented in a lucid and concise manner, this book employs a systems-oriented approach that applies knowledge gained to clinical practice. In addition, the extensive, highly praised marginal notes allow central points and concepts to be clearly identified. Graduate students studying medical microbiology, infectious disease physicians, clinical microbiologists and internists alike will find it an indispensable reference book.A comment on the first edition: "The book is recommended for those who wish a readable presentation of medical microbiology". -American Society for Microbiology News

Antiviral Chemotherapy II

  • 1st Edition
  • J. Mills + 1 more
  • English
This new volume presents a state-of-the-art review of antiviral chemotherapy. Antiviral Chemotherapy II details: - major antiviral agents and their antiviral spectrum of action - appropriate antiviral therapy for mucocutaneous herpes simplex infections - mechanisms of action of interferon and selected nucleoside analogs - the pharmacology and toxicity of acyclovir - proper indications for amantidine or rimantidine therapy of influenza - indications for and benefits of ribavirin therapy for respiratory syncytial virus infections Antiviral Chemotherapy II is a practical guide to treating viral infections. Physicians with an interest in infectious diseases, general internists and pediatricians, as well as researchers interested in clinical virology, will all benefit from up-to-date review on antiviral chemotherapy.

Advances in Veterinary Immunology 1983

  • 1st Edition
  • F.J. Bourne + 1 more
  • English
This is the third volume in a series of special issues, published annually, whose objective is to review advances in our understanding of the functioning of the immune system of domestic animals; the two previous volumes were edited by F.D. Kristensen and D.F. Antczak.Veterinary immunology has grown rapidly during the last decade and the knowledge gained from this work can be applied beyond the confines of domestic species. It is with this wider relevance of veterinary immunology to other fields that the topics have been chosen for this edition of Advances in Veterinary Immunology. It comprises an editorial followed by five review articles which, in their different ways, emphasise the growth of veterinary immunology and its relevance to biological and medical science.

Veterinary Immunology

  • 1st Edition
  • B.N. Wilkie + 1 more
  • English
This volume contains papers which review and discuss the current state of the art in veterinary immunology, presented during the first truly international gathering in this field.

In Vitro Immunization in Hybridoma Technology

  • 1st Edition
  • C.A.K. Borrebaeck
  • English
This volume presents an overview and the state-of-the-art of the progress in the field of in vitro immunization for the production of monoclonal antibodies. Part I focuses on in vitro immunization of mouse B lymphocytes and presents detailed data from established approaches, giving high yields of monoclonal antibodies. Part II focuses on in vitro immunization of human B lymphocytes and how to design a general primary in vitro system. It is the first time that this subject has been dealt with so comprehensively in a single book. Hitherto, there have only been short review articles that dealt with a fraction of this data. The book thus provides a wealth of up-to-date information which will be of value to scientists in the areas of immunology, pharmacy, biotherapy, cell biology, biochemistry, medicine etc. It should also be on the library shelf of all pharmaceutical companies. Contents: 1. In Vitro Immunization of Mouse B Lymphocytes. Development of an in vitro immunization technique for the production of murine monoclonal antibodies using small amounts of antigen and weak immunogens (S.A. Möller, C.A.K. Borrebaeck). Properties and specificity of monoclonal antibodies obtained after immunization in vitro: Experience with different antigens (J.M. Tager et al.). In vitro antigen priming of immunocompetent cells against both immunogenic and highly conserved epitopes using silica as the antigen carrying matrix plus anti T-suppressor drugs administered in the media (P. Brams). Stimulation in vitro of sensitized splenocytes for the generation of antigen specific hybridomas (M. De Boer et al.). Production of murine monoclonal antibodies by in vitro stimulation (A.L. Helleman et al.). Is there a difference in tolerance for self during primary immunization in vivo and in vitro? (F.A. Ossendorp et al.). Dose dependent modulation of monoclonal antibody affinities by in vitro immunization (M. Wallén et al.). Natural antibodies - Confounding factors in the production of monoclonal antibodies (L. Lögdberg). Optimization of murine in vitro immunization against different antigens (C. Glad et al.). In vitro immunization against human glucocorticoid receptor adsorbed onto nitrocellulose (A.-C. Wikström et al.). Monoclonal anti-idiotypic antibodies to a proinsulin specific antibody using in vitro booster immunization (T.C. Beck et al.). In vitro primary immunization for the obtention of mouse monoclonal antibodies against human recombinant gamma interferon and epidermal growth factor (J. Gavilondo-Cowley et al). 2. In Vitro Immunization of Human B Lymphocytes. The IgM antibody response in cultures of mouse and human lymphoid cells (M.K. Hoffmann et al.). Strategies for the immortalization of B lymphocytes (Z.L. Jonak et al.). In vitro stimulated lymphocytes as a source of human monoclonal antibodies generated by the EBV-hybridoma technique (D. Kozbor). Human monoclonal antibodies produced from primary in vitro immunized leucine methyl ester-treated peripheral blood lymphocytes (C.A.K. Borrebaeck). Generation of specific human monoclonal antibodies by in vitro expansion of human B cells: A novel recombinant DNA approach (J.W. Larrick et al.). Human monoclonal antibodies produced by in vitro immunization (M.-K. Ho). In vitro immunization of human splenocytes against a haptenated protein (N. McRoberts et al.). Production of human monoclonal antibodies against specific antigens by in vitro immunization (B.J. Pollock et al.). Production of human monoclonal antibodies against Haemophilus influenzae type B using a heteromyeloma (D. Martin et al.). Human monoclonal antibodies obtained by fusion with a heteromyeloma (H. Jacot-Guillarmod). In vitro immunization of PBL with HJuMTV, and the production of human mAbs reacting with MMTV and HuMTV (Y. Shoenfeld et al.). A new progression factor for stimulation of human B cells in vitro (A. Rosén et al.).

Genes and Viruses in Multiple Sclerosis

  • 1st Edition
  • M. Clanet + 2 more
  • English
The European Charcot Foundation, in its goal to support and stimulate information on new developments in Multiple Sclerosis (MS), presents an up-to-date volume on the relation of genes and viruses to MS. That genetic susceptibility might play an important role in the way the immunological system handles viral infection, or in the way brain cells react to viral invasion, has in recent years been extensively studied. Experimental evidence from animals makes a viral oligodendrocytopathy a certainty, and this in itself opens the perspective of such a disease in human beings. New insights in MS-pathology indicate that in a number of MS-patients an oligodendrocytopathy is paramount, however, proof that this may be virus-induced is absent so far.This book discusses viral activities in the brain of Multiple Sclerosis patients, genetic backgrounds in MS and their role in brain response to viral infections, and provides evidence for viral pathogenesis of Multiple Sclerosis.

The Mode of Action of Immunosuppressive Agents

  • 1st Edition
  • J.F. Bach + 1 more
  • English
This completely updated work presents a unique source of references describing the cellular, subcellular and molecular mode of action of the main immunosuppressive agents used clinically. The following six agents (or methods) have been considered: azathioprine, corticosteroids, cyclophosphamide, cyclosporine, antilymphocyte antibodies (monoclonal and polyclonal), and total lymphoid mediation.Experimental and human immunological data is presented in a comprehensive way to show synthetically the mode of action of these agents in patients.Readers potentially interested in this work include clinical and basic immunologists, nephrologists, rheumotologists, dermatologists, hematologists, transplant surgeons and physicians, internal medicine specialists and clinicians of nearly all disciplines interested in automimmune diseases.

Molecular Mechanisms of Transmembrane Signalling

  • 1st Edition
  • Volume 4
  • P. Cohen + 1 more
  • English
Over the past few years great strides have been made in the characterisation and purification of receptors and in elucidating the mechanisms by which extracellular signals, acting through receptors, regulate transmembrane signalling systems that control production of second messengers within the target cells. This book highlights the recent impressive advances in this area, which have led to the emergence of unifying concepts, and the linkage of areas in biology that were previously thought of as being quite separate.