Perspectives in Biometrics

List of Contributors

Preface


1. Interactive Statistical Computation with Large Data Structures

I. Introduction

II. The Data and the Computing Facilities

III. The Example

IV. Summary of Further Analyses

V. Comments on Interactive Data Analysis Systems

References


2. A Survey of Adaptive Sampling for Clinical Trials

I. Introduction

II. The Finite Patient Horizon Model

III. The Unknown Patient Horizon

IV. Ranking and Selection Models

V. Inverse Stopping

VI. Likelihood Stopping Rules

VII. Delayed Observations

VIII. Conclusions

Appendix

References


3. Computer-Aided Prognosis

I. Introduction

II. Description of the Data

III. Density Estimation Methods

IV. Regression Estimation Methods

V. Results for Density Estimation Methods

VI. Results for the Regression Estimation Methods

References


4. The Use and Interpretation of Multivariate Methods in the Classification of Stages in Serious Infectious Disease Processes in the Critically

I. Introduction and Background of the Medical Problem and Data Description

II. An Approach to the Development of a Physiologic State Point of View

III. A Description of the Clustering Process

IV. The Concatenation of Multivariate Methods

V. Longitudinal Aspects of the Analysis—The Time Dimension—Can it Be Recovered?

VI. Conclusions

References


5. Approximate Tests and Confidence Intervals Using the Jackknife

I. Introduction

II. Approximate Tests and Confidence Intervals

III. Some Possible Extensions

References


6. Estimation Procedures for Simulation Applications

I. Statement and Outline of the Problem

II. Basic Structure

III. Interpretation of Parameters

IV. General Aspects of Estimation

V. Applications to Biomedical Problems

VI. Generalizations

Appendix. Consideration of Systematic Scale Estimators under the Assumption of Symmetry

References

Index