Parkinson's Disease and Related Disorders Part I
- 1st Edition, Volume 83 - June 25, 2007
- Latest edition
- Editors: William C. Koller, Eldad Melamed
- Language: English
This volume provides a complete guide to advancements made in the understanding of Parkinson’s disease and related neurodegenerative disorders. From information on early re… Read more
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Description
Description
This volume provides a complete guide to advancements made in the understanding of Parkinson’s disease and related neurodegenerative disorders. From information on early research conducted in the 1960’s, to modern clinical views of these diseases, this handbook will give clinicians and neuroscientists a state-of-the-art reference that presents critical appraisals on recent developments in the study of these disorders.
As the world population in developed countries ages, these observations are particularly relevant. Dramatic data on the genetic causes of dominant and recessive forms of hereditary Parkinson’s disease are presented, as well as new knowledge on the differences in the intricate circuitry of basal ganglia in healthy individuals and those afflicted with Parkinson’s.
Clinicians will find this to be a great platform on which to base ongoing investigative approaches and research.
Key features
Key features
* A comprehensive accounting of the parkinsonian disorders, including pharmacological advances, patient management techniques, and therapeutic strategies
* Critical appraisals of recent developments in the field that further clinical research and foster new investigative approaches
Readership
Readership
Table of contents
Table of contents
Anatomy and physiology of the basal ganglia: relevance to parkinson’s disease and related disorders. Functional neurochemistry of the basal ganglia. Dopamine receptor pharmacology.
Section 2: General aspects of Parkinson's disease
History of Parkinson’s disease. Epidemiology of Parkinson’s disease. Neurochemistry of the basal ganglia in Parkinson’s disease. The neuropathology of parkinsonism. Imaging Parkinson’s disease. Parkinson’s disease: animal models.
Section 3: Clinical aspects
Scales to measure parkinsonism. Motor symptoms in Parkinson’s disease. Autonomic dysfunction in Parkinson’s disease. Sleep in Parkinson syndromes. Sensory symptoms in Parkinson’s disease. Speech disorders in Parkinson’s disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment. Clinical features, pathophysiology and treatment of dementia associated with Parkinson’s disease. Disorders of mood and affect in Parkinson’s disease. Neurobehavioral disorders in Parkinson’s disease. Early detection of Parkinson’s disease.
Section 4: Etiology
Mitochondria in the etiology of Parkinson’s disease. Iron as a trigger of neurodegeneration in Parkinson’s disease. Oxidative stress and Parkinson’s disease. Neurotrophic factors and Parkinson’s disease. Neuroinflammation and Parkinson’s disease. Excitotoxicity. Protein handling dysfunction in Parkinson’s disease. Programmed cell death in Parkinson’s disease.
Product details
Product details
- Edition: 1
- Latest edition
- Volume: 83
- Published: June 25, 2007
- Language: English
About the editors
About the editors
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William C. Koller
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