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Fetal-Placental Disorders

1st Edition - January 1, 1972

Editor: Nicholas S. Assali

eBook ISBN:

9 7 8 - 1 - 4 8 3 2 - 6 2 6 9 - 7

Pathophysiology of Gestation, Volume II: Fetal-Placental Disorders covers important areas of reproduction such as maternal-fetal interrelationship, biochemistry and physiology of… Read more

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Pathophysiology of Gestation, Volume II: Fetal-Placental Disorders covers important areas of reproduction such as maternal-fetal interrelationship, biochemistry and physiology of the fetoplacental unit, and use of amniotic fluid constituents as diagnostic tools for fetal well-being. This book is divided into five chapters. Chapter 1 deals with the disorders of placental transfer, clearly illustrating the physical and biochemical processes involved in placental exchanges between mother and fetus. The second chapter is devoted to disorders of placental endocrine functions. The various methods used for studying placental hormone production and the errors in analysis and interpretation of the results are also elaborated. The pathophysiology of amniotic fluid disorders is discussed in Chapter 3, while the genetic factors affecting growth and development from the gamete stage through fertilization and organ formation are described in Chapter 4. The last chapter considers the teratologic impact of the environmental factors on fetal growth and development. This volume is valuable to medical students and individuals concerned with the disorders of the maternal-fetal interrelationship.

List of Contributors

Preface

Contents of Other Volumes

1 Disorders of Placental Transfer

I. Introduction

II. Physiological Transfer Mechanisms

III. Normal Transfer of Specific Substances

IV. Relation between Normal Placental Structure and Function

V. Alteration in Placental Transfer Mechanisms

VI. The Placenta and the Small-for-Gestational-Age Infant

VII. Diagnostic Tests of Altered Placental Transfer

VIII. Sequel of Altered Placental Function

IX. Possible Therapy for Altered Placental Transfer

X. Summary

References

2 Disorders of Placental Endocrine Functions

I. Introduction

II. Methodology

III. Altered Placental Estrogen Production

IV. Altered Placental Progesterone Production

V. Altered Placental Production of Polypeptide Hormones

VI. Endocrinology of Placental Lesions

References

3 Disorders of Amniotic Fluid

I. Introduction

II. Volume

III. Composition

IV. The Dynamics of Amniotic Fluid Constituents

V. The Routes of Exchange of Amniotic Fluid Constituents

VI. The Regulation and Aberrations of Amniotic Fluid Volume

VII. Variations and Aberrations of Amniotic Fluid Constituents - Relation to Fetal Maturity

Conclusion

References

4 Genetic Disorders Affecting Growth and Development

I. Introduction

II. Genetics of Gametes

III. Anomalies of FertiHzation

IV. Chromosomes in Man

V. Molecular and Biochemical Considerations

VI. Mendelian Factors—Chromosomal Inheritance

VII. Polygenic Inheritance

VIII. Extrachromosomal Inheritance

IX. Genetics of Sex Development

X. Genetic Factors in "Environmental" Teratology

XI. Prenatal Diagnosis

XII. Experimental Approaches in Mammals

XIII. Modification of Genetic Aspects of Development (Principles of Treatment)

XIV. Genetic Counseling

XV. Future Prospects

References

5 Environmental Effects on Development—Teratology

I. Introduction

II. Scope of Teratology Today

III. The Degree of Teratogenic Risk for Man

IV. Causes of Developmental Defects in Man

V. Concluding Comment

References

Author Index

Subject Index