Bacterial Immunoglobulin-binding Proteins V1

1st Edition - December 2, 2012
Imprint: Academic Press
Author: Michael D.P. Boyle
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 4 1 2 0 9 8 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 0 5 8 - 4

Bacterial Immunoglobulin-Binding Proteins, Volume 1: Microbiology, Chemistry, and Biology investigates the immunoglobulin and Fc-binding proteins that have been isolated and… Read more

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Bacterial Immunoglobulin-Binding Proteins, Volume 1: Microbiology, Chemistry, and Biology investigates the immunoglobulin and Fc-binding proteins that have been isolated and characterized from a wide array of microorganisms, including protein A from staphylococcus and protein G from streptococcus. It examines the antigenic relationships among bacterial immunoglobulin-binding proteins, the immunoglobulin D-binding bacteria, the complement activation and bacterial immunoglobulin-binding proteins, the nature of the interaction of bacterial Fc receptors and immunoglobulin G, and the bacterial Fc receptors as putative virulence factors. Organized into 31 chapters, this volume begins with a historical overview of bacterial immunoglobulin-binding proteins, receptors for immunoglobulins, amino acid sequence of Fc receptors, and cloning of genes. It then discusses the staphylococcal protein A, including its biological activities and applications to immunotechnology. The book also explains the gene for staphylococcal protein A, immunoglobulin G Fc receptors of group A streptococci, and streptococcal protein G. It presents the structure and evolution of the streptococcal genes encoding protein G and interaction of bacterial immunoglobulin receptors with sites in the Fab region. It also discusses the lymphocyte stimulation by bacterial Fc receptors and cloning and expression of the beta protein gene of group B streptococci. The book concludes with a chapter on Fc receptors and the pathogenesis of bacterial infections in animals. This book will be of interest to biologists, microbiologists, chemists, and researchers working with immunoglobulin-binding proteins found in bacteria.

Contributors

Foreword

1 Historical perspective

I. Background

II. Protein A: Fc Receptor Type I

III. Fc Receptors in ß-Hemolytic Streptococci

IV. Alternative Ig Binding: Nonimmune Fab Binding

V. Other Receptors for Immunoglobulins

VI. Amino Acid Sequence of Fc Receptors and Cloning of Genes

VII. Concluding Remarks

References

2 The type I bacterial immunoglobulin-binding protein: Staphylococcal protein A

I. Introduction

II. Biological Activities of Protein A

III. Applications of Protein A to Immunotechnology

IV. Summary

References

3 The gene for staphylococcal protein A

I. Cloning and Sequencing of the Gene

II. The Structure of the Gene

III. Expression of the Cloned Protein A Gene in Different Species

IV. Comparison of Protein A to Streptococcal Protein G

V. Chimeric Fc Receptors

VI. Concluding Remarks

References

4 Morphological distribution of Fc receptors on group A streptococci

I. Introduction

II. Electron Microscopic Demonstration of Fc Receptors

References

5 Immunoglobulin G Fc receptors of group A streptococci

I. Introduction

II. The Detection of IgG Fc Receptor Activity in Group A Streptococci

III. Classification of IgG Fc Receptors

IV. Restricted Binding of Human IgG by Group A Streptococcal Fc Receptors

V. Precipitation in Gel of Human Normal Sera by Group A Streptococcal Fc Receptor

VI. Isolation of an Allotype-Specific Fc Receptor from Group A Streptococci

VII. Purification of an Fc Receptor with Unrestricted Binding of Human IgG from Group A Streptococci

VIII. Relation between IgG Fc Receptor and Other Factors of Group A Streptococci

IX. Monoclonal Antibody to Group A Streptococcal Fc Receptor

X. Concluding Remarks

References

6 Type Ila and type lib immunoglobulin-binding proteins associated with group A streptococci

Text

References

7 Type II immunoglobulin receptor and its gene

I. Immunoglobulin G Receptors of Group A Streptococci

II. The frcA Gene

III. The FcRA76 Protein Deduced from the Nucleotide Sequence

IV. Evolutionary Relationship between FcRA and M Proteins

References

8 Type III Fc immunoglobulin-binding proteins from a group C streptococcus: Isolation and characterization

I. Introduction

II. Purification of a Type III Immunoglobulin-Binding Protein

III. Functional Properties of Type III Immunoglobulin-Binding Proteins

IV. Comparison of the Immunoglobulin-Binding Proteins Expressed by Human Group C and Group G Streptococci

V. Summary

References

9 Streptococcal protein G

I. Introduction

II. Purification of Protein G

III. Structure

IV. Binding Specificity and Affinity

V. Interaction with Other Proteins

VI. Some Functional Aspects of Protein G

References

10 Type III Fc receptors from streptococci of serological group L

I. Introduction

II. Interactions of L Streptococci with Immunoglobulin G

III. Isolation and Characterization of IgG Fc Receptors

IV. Conclusions

References

11 Structure and evolution of the streptococcal genes encoding protein G

I. Structure of Protein G

II. Structural Variation

III. Relation to Other Gram-Positive Cell Wall Proteins

IV. Localization of Functional Regions

V. Expression of the Cloned Gene in Recombinant Hosts

References

12 Type IV bacterial immunoglobulin-binding proteins

Text

Summary

References

13 Type V Fc receptor from Streptococcus zooepidemicus

I. Introduction

II. Isolation, Purification, and Physical Characteristics

III. Distribution among Isolates

IV. Functional Activity

V. Summary

References

14 Isolation and characterization of a type VI immunoglobulin-binding protein

Text

References

15 Antigenic relationships among bacterial immunoglobulin-binding proteins

I. Introduction

II. Antigenically and Functionally Distinct Immunoglobulin-Binding Proteins

III. Antigenically Related and Functionally Related Immunoglobulin-Binding Proteins

IV. Antigenically Related and Functionally Distinct Immunoglobulin-Binding Proteins

V. Summary

References

16 Group A streptococcal immunoglobulin A Fc receptors

I. Introduction

II. Binding of the Fc Part of Human IgA to Some Group A Streptococci

III. Presence of IgA Fc Receptor in Different Types of Group A Streptococci

IV. Separation of the IgA Fc Receptor from Other Streptococcal Factors

V. Characterization of the IgA Fc Receptor

VI. Concluding Remarks

References

17 Protein Arp, the immunoglobulin A receptor of group A streptococci

I. Introduction

II. Binding Properties of Strains Expressing Protein Arp

III. Expression of Protein Arp in Escherichia coli

IV. Sequence Studies: Relationship of Protein Arp to Streptococcal M Proteins

V. Genetic Regulation of the Protein Arp Gene

VI. Concluding Remarks

References

18 Immunoglobulin A Fc-binding proteins associated with group B streptococci

I. Introduction

II. Identification of IgA Fc-Binding Proteins Expressed by Group B Streptococci

III. Binding of slgA by IgA Fc-Binding Strains of Group B Streptococci

IV. Identification of ß Antigen Expressed by Group B Streptococci

V. Comparison of ß Antigen and IgA Fc-Binding Proteins

VI. Expression of ß Antigen/IgA Fc-Binding Proteins by Individual Colonies of Group B Streptococci

VII. Relationship of Low-Molecular-Weight Secreted ß Antigen to Other Forms of the Molecule

VIII. Affinity Purification of Low-Molecule-Weight Secreted ß Antigen

IX. IgG Fc Binding by Group B Streptococci

X. Summary

References

19 Cloning and expression of the ß protein gene of group B streptococci and a study of its product's binding capacity to human IgA

I. Introduction

II. Cloning of the ß Protein Gene in Escherichia coli

III. Subcloning of the ß Gene into Plasmid Vectors

IV. Western Blot Analysis of the Recombinant ß Antigen

V. Mutagenesis of the ß Protein Gene

VI. The IgA-Binding Capacity of the Recombinant ß Protein

VII. Discussion

References

20 Immunoglobulin D-binding bacteria

I. Introduction

II. Species of Bacteria That Bind IgD

III. Branhamella catarrhalis as a B Cell Mitogen

IV. Structure of the IgD Receptor

V. Summary

References

21 Interaction of bacterial immunoglobulin receptors with sites in the Fab region

I. Introduction

II. Immunoglobulin-Binding Bacterial Species

III. Reactivity of Immunoglobulin

IV. Biological Significance of Fab Binding

V. Concluding Remarks

References

22 Receptor for immunoglobulins in Clostridium perfringens: Binding in the F(ab')2 region

I. Introduction

II. Binding of IgM to Clostridium perfringens

III. Purification of the Binding Structure, Protein P

IV. Previous Reports on the Binding of IgM to Bacterial Proteins to Whole Bacteria

V. Concluding Remarks

References

23 Protein L: A peptococcal cell wall protein with affinity for immunoglobulin light chains

I. Introduction

II. Purification

III. Structure

IV. Specificity and Affinity

V. Some Biological Aspects of Protein L

References

24 Lymphocyte stimulation by bacterial Fc receptors

I. Introduction

II. Lymphocyte Stimulation by the Type I Fc Receptor, Staphylococcal Protein A

III. Lymphocyte Stimulation by the Type III Fc Receptor from Streptococci

IV. Methodological Problems in Studies of Fc Receptor-Induced Lymphocyte Activation

V. Conclusions

References

25 Complement activation and bacterial immunoglobulin-binding proteins

I. Introduction

II. Complement Activation by Bacterial Immunoglobulin-Binding Proteins

III. Hypersensitivity Reactions

IV. Clearance of Bacteria Expressing Immunoglobulin-Binding Proteins

V. Summary

References

26 The nature of the interaction of bacterial Fc receptors and IgG

I. Introduction

II. Structure of IgG

III. Domain Structure of IgG

IV. Structure of Fc

V. Interaction between Bacterial Fc Receptors and IgG

VI. Summary

References

27 Relationships between human rheumatoid factors and types I, II, and III bacterial Fc receptors

I. Introduction

II. Similarities of Binding Specificities of Human Rheumatoid Factors and Bacterial Fc Receptors

III. Conformational Similarities between the Antigen-Combining Regions of Rheumatoid Factors and the Fc-Binding Regions of Bacterial Fc Receptors

IV. Generation of Rheumatoid Factors by Bacterial FcRs

References

28 Therapeutic extracorporeal immunoadsorption with type I Fc receptor in systemic lupus erythematosus

I. Introduction

II. Patient Population

III. Immunoadsorption Therapy Procedure

IV. Adverse Reactions

V. Clinical, Laboratory, and Immunological Findings during Therapy

VI. In Vitro Column Studies

VII. Discussion

References

29 Bacterial Fc receptors as putative virulence factors

I. Introduction

II. Possible Virulence Mechanisms

III. Role of Protein A in Staphylococcal Virulence

IV. Effect of Classic Laboratory Methods for Manipulation of Streptococcal Virulence in IgG Fc Receptors

V. Binding of Immunoglobulins in Nephritogenic and Nonnephritogenic Streptococci

VI. Concluding Remarks

References

30 Potential role of the ß antigen (IgA Fc-binding protein) in the pathogenesis of group B streptococcal infections

I. Introduction

II. History of Group B Streptococcal Infections

III. Typing of Group B Streptococci

IV. Antibody Protection Experiments in Mice

V. Incidence of a and ß Antigens on Group B Isolates and the Incidence of Specific Human Antibodies against These Antigens

VI. Effect of the c Protein in Opsonophagocytosis and Killing of GBS

VII. Relationship of the ß Antigen and IgA-Binding Ability

VIII. Summary

References

31 Fc receptors and the pathogenesis of bacterial infections in animals

I. Introduction

II. Immunoglobulin Fc Receptors of Veterinary Bacterial Pathogens

III. Effect of Bacterial Fc Receptors on Immunological Mechanisms

IV. The Pathogenesis of Infections with Fc Receptor-Bearing Organisms

V. Conclusions

References

Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Bacterial Immunoglobulin-binding Proteins V1

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