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Advances in Radiation Biology
Volume 6
- 1st Edition - July 28, 1976
- Editors: John T. Lett, Howard Adler
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 3 5 1 1 - 0
- Hardback ISBN:9 7 8 - 0 - 1 2 - 0 3 5 4 0 6 - 1
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 8 1 9 2 - 6
Advances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study… Read more
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Request a sales quoteAdvances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study on the nature of radiation effects on nucleic acid metabolism in mammalian cells. This is followed by separate chapters on the nature of UV effects on transcriptional functions; interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage; and correlation of DNA repair activities and cellular effects in irradiated mammalian cells. Subsequent chapters deal with the interaction of heat and radiation on an in vitro and an in vivo system; the role of hyperthermia for cancer therapy; thermal potentiation of mammalian cell killing; and autologous stem-cell banks for restoring hemopoiesis.
Contributors
Contents of Other Volumes
Effects of Ionizing Radiation on Nucleic Acid Synthesis in Mammalian Cells
I. Introduction
II. Effects of Radiation on the DNA Synthetic Period
III. Radiation Effects on DNA Precursor Metabolism and DNA Synthesis
IV. Possible Mechanisms Associated with Radiation-Induced Depression of DNA Synthesis
V. Ionizing Radiation and RNA Metabolism in the Cultured Mammalian Cell
References
UV Damage at the Transcriptional Level
I. Introduction
II. In Vitro Transcription of UV-Irradiated DNA Templates
III. In Vivo Transcription of UV-Irradiated DNA
IV. RNA Synthesis in UV-Irradiated Bacteria
V. RNA Synthesis in UV-Irradiated Eukaryotic Cells
VI. Quantitative Correlation of UV Effects on the Transcriptional Template Functions of DNA
VII. Nature of Transcription-Terminating UV Lesions
VIII. Investigating Transcriptional Linkage through UV-Induced RNA Chain Termination
IX. Concluding Remarks
Glossary
References
Interrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage
I. Introduction
II. Interrelationships between Protein Synthesis and the Physiological Expression of Radiation Damage
III. Inhibition of Protein Synthesis
IV. Conclusions
References
Role of DNA Repair in Cell Inactivation, Aging, and Transformation: A Selective Review, A Speculative Model
I. Introduction
II. DNA Repair in Irradiated Mammalian Cells
III. Effects of Radiation in Mammalian Cells
IV. A Model for Correlation of DNA Repair Activities and Cellular Effects in Irradiated Mammalian Cells
References
Response of Cells in Vitro and Tissues in Vivo to Hyperthermia and X-Irradiation
I. Introduction
II. Effect of Hyperthermia Alone in Vitro
III. Effect of Hyperthermia Plus Radiation in Vitro
IV. Effect of Hyperthermia Alone in Vivo
V. Effect of Hyperthermia and Radiation in Vivo
VI. Discussion
VII. Summary
References
Experimental and Clinical Aspects of Hyperthermia Applied to the Treatment of Cancer with Special Reference to the Role of Ultrasonic and Microwave Heating
I. Introduction
II. Methods of Inducing Hyperthermia
III. Mechanisms of Action
IV. Effects of Hyperthermia Alone
V. Effects of Hyperthermia with Radiation
VI. Effects of Hyperthermia with Chemotherapy
VII. Microwaves in Cancer Therapy
VIII. Ultrasound in Cancer Therapy
IX. General Summary and Conclusions
References
Thermal Potentiation of Mammalian Cell Killing: Clues for Understanding and Potential for Tumor Therapy
I. Introduction
II. Effect of Heat Alone on Cells
III. Theoretical Framework for Thermal and Radiation Experiments
IV. Thermal Potentiation of Cell Killing
V. DNA, Strand Breaks, Thermal Effects, and Repair
VI. Remarks on Thermal Potentiation in Tumor Systems
VII. Summary
VIII. Conclusion
Appendix
References
Autologous Stem-Cell Banks for Restoring Hemopoiesis
I. Introduction
II. Treating the Hemopoietic Syndrome
III. Stem Cells in Blood
IV. Cryopreservation
V. Feasibility
VI. Summary
References
Subject Index
- No. of pages: 356
- Language: English
- Edition: 1
- Published: July 28, 1976
- Imprint: Academic Press
- Paperback ISBN: 9781483235110
- Hardback ISBN: 9780120354061
- eBook ISBN: 9781483281926