NAM Journal
New Approach Methodology
Volume 1 • Issue 1
- ISSN: 3050-6204
The use of animals for toxicological and safety testing of medicinal products and devices, food and feed and related ingredients, biocides and any other type of chemical co… Read more
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Request a sales quoteThe use of animals for toxicological and safety testing of medicinal products and devices, food and feed and related ingredients, biocides and any other type of chemical compounds or products as well as for biomedical research is increasingly criticized because of ethical concerns regarding animal welfare as well as given scientific flaws due to lack of human or ecological relevance. As a result, the fields of scientific research and regulatory testing are currently facing a paradigm shift moving from animal experimentation towards the use of so-called new approach methodologies (NAMs). Within the area of toxicology and safety evaluation of chemicals, the development and use of NAMs complies with the principles of 21st century toxicity testing and next generation risk assessment. These NAMs may serve a plethora of purposes, including hazard identification, kinetic modelling and exposure assessment, both for human toxicology and ecotoxicology. NAMs in the biomedical research area are typically used for, but not restricted to, the investigation of mechanisms underlying human disease, the identification of novel diagnostic and prognostic biomarkers, and the testing of new therapeutic strategies of various nature. Both in the toxicology and biomedical areas, NAMs can adopt a broad spectrum of formats, including in vitro (cell culture) methods and in silico (computational) tools, many of which rely on machine learning and artificial intelligence.
NAM Journal embraces these recent advancements by serving as a hub for dissemination and worldwide exchange of information regarding state-of-the-art NAM developments. NAM Journal welcomes original research papers, review papers, opinion papers and meeting reports dealing with NAM production and their use in human toxicology, ecotoxicology, chemical risk assessment and biomedical research, amongst other fields. While focus is put on full replacement of animal experimentation, manuscripts that support other 3Rs principles, including reduction and refinement of animal experimentation, will also be considered when well justified. Manuscripts can address all elements of the NAM life cycle, from conceptual development to acceptance, implementation and application. NAM Journal is a 3I (international, interdisciplinary and intersectoral) journal and encourages submission from all relevant disciplines, ranging from natural, formal, life and applied sciences all up to social sciences and humanities. The NAM Journal target audience includes undergraduates to full professionals in academic, industrial and regulatory settings in any part of the world.
- ISSN: 3050-6204
- Volume 1
- Issue 1